The pre- and postjunctional components of the neuromuscular effect of antibiotics

1991 ◽  
Vol 5 (1) ◽  
pp. 1-9 ◽  
Author(s):  
E. Sylvester Vizi ◽  
Ijaz A. Chaudhry ◽  
Paul l. Goldiner ◽  
Yoshio Ohta ◽  
Hideo Nagashima ◽  
...  
Keyword(s):  
Neuromuscular Effect

MECHANISM OF THE NEUROMUSCULAR EFFECT OF NEOMYCIN

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A792 ◽  
Author(s):  
I. A. Chaudhry ◽  
F. F. Foldes ◽  
N. Manabe ◽  
P. L. Goldiner ◽  
E. S. Vizi
Keyword(s):  
Neuromuscular Effect

Video Imaging to Assess the Neuromuscular Effect at the Larynx

2006 ◽  
Vol 50 (3) ◽  
pp. 262
Author(s):  
Kyung Seon Bang ◽  
Joon Yong Do ◽  
Il Seok Kim ◽  
Seong Joon Hong ◽  
Keun Man Shin
Keyword(s):  
Video Imaging ◽  
Neuromuscular Effect

Neuromuscular Effect of Sevoflurane in Patients with Myasthenia Gravis

2002 ◽  
Vol 96 (Sup 2) ◽  
pp. A996
Author(s):  
Keiichi Nitahara ◽  
Kiyoshi Katori ◽  
Shinjiro Shono ◽  
Tadakazu Sakuragi ◽  
Kazuo Higa
Keyword(s):  
Myasthenia Gravis ◽  
Neuromuscular Effect

NEUROMUSCULAR EFFECT OF PIPECURONIUM IN INFANTS AND CHILDREN DURING NITROUS OXIDE-ALFENTANIL ANESTHESIA

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A779
Author(s):  
J. F. Pittet ◽  
E. Tassonyi ◽  
G. Gemperle ◽  
D. R. Morel ◽  
J. C. Rouge
Keyword(s):  
Nitrous Oxide ◽  
Infants And Children ◽  
In Infants And Children ◽  
Neuromuscular Effect

SPECIES VARIATION IN THE NEUROMUSCULAR EFFECT OF A NEW MUSCLE RELAXANT (ORG9426) IN RODENTS

1991 ◽  
Vol 18 ◽  
pp. 379-380
Author(s):  
I.A. Chaudhry ◽  
H. Nagashima ◽  
P.L. Goldiner ◽  
F.F. Foldes
Keyword(s):  
Muscle Relaxant ◽  
Species Variation ◽  
Neuromuscular Effect

Neuromuscular effect of venoms from adults and juveniles of Crotalus durissus cumanensis (Humboldt, 1811) from Guajira, Colombia

Toxicon ◽  
2017 ◽  
Vol 139 ◽  
pp. 41-44 ◽  
Author(s):  
Miguel Arévalo-Páez ◽  
Efraín Rada-Vargas ◽  
César Betancur-Hurtado ◽  
Juan M. Renjifo ◽  
Camila Renjifo-Ibáñez
Keyword(s):  
Crotalus Durissus ◽  
Neuromuscular Effect ◽  
Crotalus Durissus Cumanensis

IN VITRO NEUROMUSCULAR EFFECT OF ACETAMINOFYRIDINE-N-OXIDE

1980 ◽  
Vol 53 (3 Suppl) ◽  
pp. S283-S283
Author(s):  
Y. AMAKI ◽  
K. KOBAYASHI ◽  
C. KIBAYASHI
Keyword(s):  
Neuromuscular Effect

The Effect of Neostigmine on Twitch Tension and Muscle Relaxant Concentration during Infusion of Mivacurium or Vecuronium

1995 ◽  
Vol 83 (1) ◽  
pp. 83-87. ◽  
Author(s):  
Janos Szenohradszky ◽  
Marie Lau ◽  
Ronald Brown ◽  
Manohar L. Sharma ◽  
Dennis M. Fisher
Keyword(s):  
Cholinesterase Activity ◽  
Plasma Concentrations ◽  
Neuromuscular Function ◽  
Plasma Cholinesterase ◽  
Constant Infusion ◽  
Plasma Cholinesterase Activity ◽  
Limited Efficacy ◽  
Before And After ◽  
Neuromuscular Effect

Background An investigation suggested that neostigmine may not effectively antagonize mivacurium, presumably because neostigmine impairs mivacurium's metabolism. However, the effect of neostigmine on mivacurium's metabolism in vivo has not been reported. Therefore, the effect of neostigmine on neuromuscular function and plasma mivacurium concentrations during constant mivacurium infusion was determined. Methods Mivacurium was infused in five patients to maintain 90% depression of adductor pollicis twitch tension, then 50 micrograms/kg intravenous neostigmine was administered without altering the mivacurium infusion. Peak twitch tension after neostigmine, plasma cholinesterase activity, and mivacurium concentrations before and after neostigmine were measured. Five additional patients were given 50 micrograms/kg neostigmine to antagonize block due to continuous infusions of vecuronium. Results Neostigmine produced less antagonism of mivacurium (39 +/- 11%) than of vecuronium (54 +/- 9%, P < 0.05). Neostigmine decreased plasma cholinesterase activity and increased plasma concentrations of the trans-trans and cis-trans stereoisomers of mivacurium (P < 0.05). Conclusions Neostigmine is less effective at antagonizing the neuromuscular effect of mivacurium than that of vecuronium during constant infusion. Neostigmine increases plasma mivacurium concentrations, likely explaining its limited efficacy. Our results confirm that neostigmine impairs the metabolism of mivacurium in vivo and may explain the observation that neostigmine may not effectively antagonize mivacurium-induced block.

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