Colorectal carcinoma with special reference to growth pattern classifications: clinicopathologic characteristics and genetic changes

2002 ◽  
Vol 37 (5) ◽  
pp. 354-362 ◽  
Author(s):  
Toshinori Kurahashi ◽  
Kazuhiro Kaneko ◽  
Reiko Makino ◽  
Keiji Mitamura
Keyword(s):  
Colorectal Carcinoma ◽  
Special Reference ◽  
Growth Pattern ◽  
Clinicopathologic Characteristics ◽  
Genetic Changes

Colorectal tumours examined for genetic changes at chromosomes 13 and 17 with special reference to the RB1 and TP53 genes

1992 ◽  
Vol 63 (2) ◽  
pp. 123
Author(s):  
R.A. Lothe ◽  
T. Fossli ◽  
H.E. Danielsen ◽  
A.E. Stenwig ◽  
J.M. Nesland ◽  
...  
Keyword(s):  
Special Reference ◽  
Genetic Changes ◽  
Colorectal Tumours

scholarly journals Correlation Between Programmed Cell Death Ligand1 (PD-L1) Expression and Clinical Parameters in Colorectal Carcinoma.

2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Zainab Waleed Aziz ◽  
Asmaa Mohammadsheet Mahmood ◽  
Zahraa Osama Yahiya ◽  
Wahda Mohammed Taib Al –Nuaimy
Keyword(s):  
Cell Death ◽  
Colorectal Carcinoma ◽  
Programmed Cell Death ◽  
Lymph Nodes ◽  
Tissue Microarray ◽  
Tissue Expression ◽  
Tumor Location ◽  
Lymphatic Invasion ◽  
Tnm Stage ◽  
Clinicopathologic Characteristics

Abstract     Objectives: Programmed Cell Death Ligand1 (PD-L1) tissue expression in CRC (colorectal cancer) displays conflicting results among various studies. We aimed to identify the rate of PD-L1 positivity in colorectal carcinoma, and it's immune infiltrating cells, their relationship with clinicopathologic parameters of patients, and to correlate the results with other studies.    Methods: PD-L1 antibody retrospectively analyzed immunohistochemically in tissue microarray blocks of 99 specimens with colonic and rectal carcinomas operated between January 2015 to December 2017. A comparison performed between PD-L1 expression  in tumor cells (TCs) as well as tumor-infiltrating immune cells (TIICs) for age, sex, histological differentiation, the primary tumor location, number of involved lymph nodes, angiolymphatic invasion, and TNM stage.   Results: Of the 99 patients, the median age was 54.5 (range: 18 to 83) years. Fourteen samples were PD-L1 positive in TCs, increased to 32%  in TIICs. A significant expression of PD-L1in TCs was correlated with medullary histology (p= 0.03), number of the involved lymph nodes (p= 0.02), distant metastasis (p= 0.001), and TNM stage (p= 0.0001). The PD-L1 status in TIICs was again connected with adverse clinical and pathological parameters.    Conclusions: The expression of PD-L1 in TCs and TIICs is associated significantly with advanced cancer or lymphatic invasion in patients who underwent surgery after a diagnosis of CRC. The research designates the significance of estimation of TCs and TIICs in correlation to clinicopathologic characteristics of patients a finding that could produce a piece of evidence for precise electing immunotherapy.       Keywords: Programmed cell death ligand1, colorectal carcinoma, Tissue microarray study, Immunohistochemistry.      

scholarly journals Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection

2012 ◽  
Vol 27 (6) ◽  
pp. 1057-1062 ◽  
Author(s):  
Koichi Nakadoi ◽  
Shinji Tanaka ◽  
Hiroyuki Kanao ◽  
Motomi Terasaki ◽  
Sayaka Takata ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Special Reference ◽  
Endoscopic Resection ◽  
T1 Colorectal Carcinoma
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