Time series analysis supporting the hypothesis that enhanced cosmic radiation during germ cell formation can increase breast cancer mortality in germ cell cohorts

1997 ◽  
Vol 40 (4) ◽  
pp. 206-222 ◽  
Author(s):  
D. A. Juckett ◽  
Barnett Rosenberg
Keyword(s):  
Breast Cancer ◽  
Time Series ◽  
Time Series Analysis ◽  
Germ Cell ◽  
Cancer Mortality ◽  
Cosmic Radiation ◽  
Breast Cancer Mortality ◽  
Cell Formation ◽  
Series Analysis ◽  
Germ Cell Formation

scholarly journals Temporal trends in female breast cancer mortality in Brazil and correlations with social inequalities: ecological time-series study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Carolina Maciel Reis Gonzaga ◽  
Ruffo Freitas-Junior ◽  
Maria-Paula Curado ◽  
Ana-Luiza Lima Sousa ◽  
José-Augusto Souza-Neto ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Time Series ◽  
Cancer Mortality ◽  
Social Inequalities ◽  
Breast Cancer Mortality ◽  
Temporal Trends ◽  
Female Breast Cancer ◽  
Time Series Study ◽  
Female Breast ◽  
Series Study

Preliminary Evidence on the Direction of Effects Between Day-to-Day Changes in Cellular Immune Activation, Fatigue and Mood in a Patient with Prior Breast Cancer: A Time-Series Analysis Approach

Pteridines ◽  
2007 ◽  
Vol 18 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Christian Schubert ◽  
Mechthild Neises ◽  
Kurt Fritzsche ◽  
Willi Geser ◽  
Francisco M. Ocana-Peinado ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Time Series ◽  
Time Series Analysis ◽  
Immune Activation ◽  
Stress System ◽  
Series Analysis ◽  
Immune System Activation ◽  
Direction Of Effects ◽  
Urinary Neopterin ◽  
Cellular Immune

Abstract This study on a patient with prior breast cancer investigated the cause-effect relations between immune system activation, fatigue and mood under real-life conditions. The 60-year old woman (primary diagnosis 5 years ago, relapse one year ago, currently no signs of recurrence) collected her entire urine for 31 days in 12 hour intervals for the determination of immune activation marker neopterin and creatinine concentrations by HPLC. This study used only the daytime urinary neopterin concentrations (from approx. 8 a.m. to 8 p.m.) and cross-correlated them with daily data from mood (3-Skalen-EWL) and fatigue (VAS) questionnaires which the patient filled in for 31 days. Serial dependencies were controlled for by applying moving average smoothing. When averaged over the whole observation period, daily fatigue, daily mood and daily urinary neopterin (average 173 μmol per mol creatinine) were within normal limits. Cross-correlational analyses revealed that increases in urinary neopterin significantly preceded increases in fatigue by 24 hours (lag 1: r = +0.424; p <0.05). The opposite direction of effects, however, existed between mood and neopterin, i.e., decreases in mood preceded increases in neopterin by 96 hours (lag 4: r = −0.697; p <0.05). The results in this patient suggest a disturbed stress system activity where negative emotions are associated with increases instead of decreases in the degree of cellular immune activation and where cellular immune activation may trigger central nervous system symptoms such as fatigue. Despite some restrictions in data quality this study shows the feasibility of gathering evidence on naturally occurring psychoimmunological cause-effect relations based on extensive serial data collection and time series analysis.

scholarly journals Predicting the Incidence and Trend of Breast Cancer Using Time Series Analysis for 2007-2016 in Qazvin

2021 ◽  
Vol 14 (1) ◽  
pp. 11-20
Author(s):  
Fatemeh Hajiabadi ◽  
Hadi Bagheri ◽  
Nasrin Tonokaboni ◽  
Maryam Zamanian ◽  
Zahra Hosseinkhani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Time Series ◽  
Time Series Analysis ◽  
Series Analysis

scholarly journals Case Report: Dynamic Interdependencies Between Complementary and Alternative Medicine (CAM) Practice, Urinary Interleukin-6 Levels, and Fatigue in a Breast Cancer Survivor

2021 ◽  
Vol 12 ◽  
Author(s):  
Magdalena Singer ◽  
Michaela Ott ◽  
Harald R. Bliem ◽  
Birgit Hladschik-Kermer ◽  
Francisco M. Ocaña-Peinado ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Time Series ◽  
Time Series Analysis ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Cancer Survivor ◽  
Interleukin 6 ◽  
Breast Cancer Survivor ◽  
Series Analysis ◽  
Complementary And Alternative

Background: This study investigated the influence of complementary and alternative medicine (CAM) techniques (i.e., Jin Shin Jyutsu, music, physiotherapy, Tai Chi, and energy healing) on urinary interleukin-6 (IL-6) levels and fatigue in a 49-year-old breast cancer survivor suffering from cancer-related fatigue and depression. Data were sampled under conditions of “life as it is lived.”Methods: For 28 days, a female breast cancer survivor collected her full urine output in 12-h intervals from about 8 a.m. to 8 p.m. and from about 8 p.m. to 8 a.m. These urine samples were used to determine urinary IL-6 levels through ELISA and creatinine concentrations via HPLC. In 12-h intervals (every morning and evening), the patient completed the DIARI, which included fatigue measurement and notes on incidents and activities such as CAM practice. In addition, the patient was interviewed weekly to identify meaningful everyday incidents. In this context, CAM practice was also discussed. Time series analysis consisted of ARIMA modeling and cross-correlational analyses (p &lt; 0.05).Results: When each CAM technique was considered separately in time series analysis, CAM was consistently associated with increases in urinary IL-6 release and decreases in fatigue. Furthermore, when all CAM techniques experienced as positive were included in one time series, a biphasic urinary IL-6 response pattern was found in which CAM practice was first preceded by decreases in IL-6 by 12–0 h and then followed by increases in IL-6 after 108–120 h. Finally, cross-correlations between IL-6 and fatigue showed that increases in IL-6 were followed by decreases in fatigue intensity after 48–60 h and, conversely, that decreases in fatigue intensity were followed by decreases in IL-6 after 24–36 h and 48–60 h.Conclusion: IL-6 increases and fatigue decreases highlight potential health-promoting effects of CAM practice. Moreover, a cyclic IL-6 pattern in response to all CAM activities experienced as positive underscores that CAM was meaningful to the patient. Additionally, a negative feedback circuit between IL-6 and fatigue intensity was detected. Taken together, this study confirms the necessity of integrating subjective meaning and dynamic complexity into biopsychosocial research in order to understand human functioning under real-life conditions.

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