Aktivierung trigeminaler Hirnstammneurone durch chemische Stimulation der Dura mater encephali

Der Schmerz ◽  
1997 ◽  
Vol 11 (5) ◽  
pp. 322-327 ◽  
Author(s):  
K. Schepelmann ◽  
A. Ebersberger ◽  
M. Pawlak ◽  
M. Oppmann ◽  
K. Meßlinger
Keyword(s):  
Dura Mater ◽  
Dura Mater Encephali

scholarly journals Role Of Cgrp In Sensitization Of Dura Mater

2001 ◽  
Vol 1 ◽  
pp. 20-20
Author(s):  
K. Messlinger
Keyword(s):  
Dura Mater ◽  
Trigeminal Nerve ◽  
Plasma Levels ◽  
Nerve Fibers ◽  
Considerable Proportion ◽  
Trigeminovascular System ◽  
Dura Mater Encephali ◽  
Related Peptide ◽  
Calcitonin Gene

The mammalian dura mater encephali is richly supplied by trigeminal nerve fibers, a considerable proportion of which contains calcitonin gene-related peptide (CGRP). As plasma levels of CGRP are increased in some forms of headaches, the question is in which way CGRP is involved in nociceptive mechanisms within the peripheral and the central trigeminovascular system.

Calcitonin gene related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat

1995 ◽  
Vol 73 (7) ◽  
pp. 1020-1024 ◽  
Author(s):  
K. Meßlinger ◽  
U. Hanesch ◽  
M. Kurosawa ◽  
M. Pawlak ◽  
R. F. Schmidt
Keyword(s):  
Blood Flow ◽  
Dura Mater ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Fibers ◽  
Dura Mater Encephali ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Meningeal Blood Flow ◽  
Meningeal Artery ◽  
Stimulation Of

The parietal dura mater encephali of the rat was shown by immunohistochemistry to be densely innervated by calcitonin gene related peptide (CGRP) immunoreactive nerve fibers spreading around the medial meningeal artery and its branches. Electrical stimulation of the dural surface (10–20 V, 5–10 Hz, 10–30 min) caused a depletion of CGRP-immunopositive fibers, suggesting a release of CGRP. The dural blood flow around branches of the medial meningeal artery was also monitored with a laser Doppler flowmeter. Short periods (30 s) of electrical stimulation with parameters that presumably released CGRP from nerve fibers caused a repeatable and constant increase of the blood flow for 1–2 min. This evoked increase could dose dependently be inhibited by topical application of the CGRP antagonist hCGRP8–37. Accordingly, administration of hCGRP increased the basal blood flow. We conclude that stimulation of trigeminal afferents innervating the dura mater releases CGRP from peptidergic afferent terminals, thereby causing vasodilatation and increasing the meningeal blood flow, an important element of neurogenic inflammation.Key words: dura mater encephali, afferent nerve fibers, calcitonin gene related peptide, immunohistochemistry, laser Doppler flowmetry.

A constitutive equation for the human dura mater encephali

1989 ◽  
Vol 22 (10) ◽  
pp. 1110
Author(s):  
Zhu Xinghua ◽  
Shi Deguang ◽  
Liu Lei
Keyword(s):  
Constitutive Equation ◽  
Dura Mater ◽  
Dura Mater Encephali

Die Angioarchitektonik der Dura mater encephali

1963 ◽  
Vol 59 (2) ◽  
pp. 153-164 ◽  
Author(s):  
F. Hammersen
Keyword(s):  
Dura Mater ◽  
Dura Mater Encephali

Response properties of trigeminal brain stem neurons with input from dura mater encephali in the rat

Neuroscience ◽  
1999 ◽  
Vol 90 (2) ◽  
pp. 543-554 ◽  
Author(s):  
K Schepelmann ◽  
A Ebersberger ◽  
M Pawlak ◽  
M Oppmann ◽  
K Messlinger
Keyword(s):  
Brain Stem ◽  
Dura Mater ◽  
Response Properties ◽  
Dura Mater Encephali

Neuropeptide Y- and substance P-like immunoreactive nerve fibers in the rat dura mater encephali

1990 ◽  
Vol 182 (4) ◽  
pp. 363-373 ◽  
Author(s):  
M. Düring ◽  
M. Bauersachs ◽  
B. Böhmer ◽  
R. W. Veh ◽  
K. H. Andres
Keyword(s):  
Substance P ◽  
Neuropeptide Y ◽  
Dura Mater ◽  
Nerve Fibers ◽  
Dura Mater Encephali
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