Renal remodelling in dietary protein modified rat polycystic kidney disease

1999 ◽  
Vol 13 (7) ◽  
pp. 567-570 ◽  
Author(s):  
Neda Bankovic-Calic ◽  
Allison Eddy ◽  
Sanjay Sareen ◽  
M. R. Ogborn
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Dietary Protein ◽  
Polycystic Kidney

scholarly journals Dietary Soy Protein Effects on Inherited Polycystic Kidney Disease Are Influenced by Gender and Protein Level

1999 ◽  
Vol 10 (2) ◽  
pp. 300-308
Author(s):  
HAROLD M. AUKEMA ◽  
IHSAN HOUSINI ◽  
JEAN M. RAWLING
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Dietary Protein ◽  
Protein Source ◽  
Polycystic Kidney ◽  
Kidney Size ◽  
Low Protein ◽  
Protein Reduction ◽  
Protein Diets

Abstract. The effects of dietary soy protein compared to casein were examined in male and female CD1-pcy/pcy (pcy) mice with polycystic kidney disease. Animals 10 wk of age were fed purified diets containing either soy protein isolate or casein given at a level of 17.4 or 6% protein. After 13 wk on the diets, body weights and serum concentrations of albumin and protein indicated that protein nutrition was adequate on all diets. Overall, animals fed soy protein versus casein had 28% lower (P = 0.0037) relative kidney weights (g/100 g body wt), 37% lower (P = 0.0089) cyst scores (% cyst area × relative kidney weight), and 25% less (P = 0.0144) kidney water (g). Dietary protein reduction resulted in 30% lower (P = 0.0010) relative kidney weights, 25% lower (P = 0.0327) cyst scores, and 35% less (P = 0.0001) kidney water. Analysis of interactions between main effects revealed that the effects of soy protein on kidney size were significant only in females, and that effects of soy protein on cyst score were significant only in animals on the low protein diets. In addition, differences in kidney weights and cyst score due to protein reduction were significant in animals fed soy protein, but not in those fed casein as the protein source. These results show that both dietary protein source and level significantly affect polycystic kidney disease in pcy animals, with the effects of dietary soy protein being most pronounced in female animals fed the low protein diets and the effects of protein reduction being most pronounced in animals fed soy protein-based diets.

scholarly journals Effects of dietary protein restriction and oil type on the early progression of murine polycystic kidney disease

1992 ◽  
Vol 42 (4) ◽  
pp. 837-842 ◽  
Author(s):  
Harold M. Aukema ◽  
Malcolm R. Ogborn ◽  
Koji Tomobe ◽  
Hisahide Takahashi ◽  
Tsutomu Hibino ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Dietary Protein ◽  
Protein Restriction ◽  
Polycystic Kidney ◽  
Dietary Protein Restriction ◽  
Early Progression ◽  
Oil Type

scholarly journals Amelioration of polycystic kidney disease by modification of dietary protein intake in the rat.

1995 ◽  
Vol 6 (6) ◽  
pp. 1649-1654
Author(s):  
M R Ogborn ◽  
S Sareen
Keyword(s):  
Body Weight ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
Polycystic Kidney ◽  
Cystic Change ◽  
Dietary Protein Restriction ◽  
Protein Group

Polycystic kidney disease is the most common potentially lethal single- gene inherited disease in man. There is no specific therapy. Previous studies in the pcy mouse model of polycystic kidney disease have shown amelioration of cystic change by reduction in dietary protein intake. The Han:SPRD-cy rat is a model of autosomal dominant polycystic kidney disease that closely resembles human disease in its histology and clinical course. We compared the morphometric assessment of cystic change and standard laboratory measures of renal function in heterozygous Han: SPRD-cy rats that received isocaloric diets containing either 8% or 20% protein as casein. This level of dietary protein restriction was associated with a significant reduction of mean body weight in the 8% protein group (358 g) compared with 20% protein (490 g; P = 0.027). Mean renal volume, adjusted for the difference in body weight, was significantly lower in the 8% protein group (6.2 mL/kg) compared with the 20% protein group (11.6 mL/kg; P = 0.016). The major component in this reduction was a reduction in total cyst volume to a mean 0.47 mL in the 8% protein group from 2.68 mL in the 20% protein group (P < 0.0001). All 8% protein diet animals survived to 6 months of age, but 3 of 11 20% protein diet animals died between 5 and 6 months of age. Mean serum creatinine and urea levels were significantly lower in the 8% protein group (118 mmol/L and 15.6 mmol/L) compared with the 20% protein group (272 mmol/L, P = 0.0033, and 81.5 mmol/L, P = 0.0002, respectively). Dietary protein restriction is a potent method for modifying the course of polycystic kidney disease in the Han:SPRD-cy/+ rat. These findings emphasize the potential for diet to alter the physiology of the renal tubulointerstitium.

scholarly journals Early dietary protein restriction slows disease progression and lengthens survival in mice with polycystic kidney disease.

1994 ◽  
Vol 5 (6) ◽  
pp. 1355-1360
Author(s):  
K Tomobe ◽  
D Philbrick ◽  
H M Aukema ◽  
W F Clark ◽  
M R Ogborn ◽  
...  
Keyword(s):  
Body Weight ◽  
Kidney Disease ◽  
Disease Progression ◽  
Polycystic Kidney Disease ◽  
Dietary Protein ◽  
Protein Restriction ◽  
Polycystic Kidney ◽  
Kidney Weight ◽  
Final Body Weight ◽  
Dietary Protein Restriction

The objective of these studies was to examine the effects of early dietary protein restriction on disease progression and survival in the DBA/2FG-pcy (pcy) mouse model of polycystic kidney disease. Male pcy mice of 70 days of age were fed either a normal protein (NP, 25% casein) or a low-protein (LP, 6% casein) diet for 105 days. At the end of the dietary treatment, kidney weight, kidney weight relative to body weight and kidney water contents were almost 50% lower, and relative renal phospholipid and triglyceride contents were almost 50% higher, in mice fed the LP diet, indicating a marked reduction in the progression of cystic disease. Morphometric analyses also revealed a lower total and percent cyst area in kidneys derived from mice on the LP compared with the NP diet. There were no significant differences in final body weight, urine volume and osmolality, GFR, proteinuria, or plasma levels of protein and urea between these two groups. In a second study, it was found that all mice fed an NP diet from 70 days of age onward had died by 310 days of age, compared with a 42% survival rate in LP-fed mice at this age. Overall, the mean lifespan for pcy mice on the LP diet was 24% longer than that for those mice on the NP diet (310 +/- 20 versus 251 +/- 16 days; P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Can progression of autosomal dominant or autosomal recessive polycystic kidney disease be prevented?

2001 ◽  
Vol 21 (5) ◽  
pp. 430-440 ◽  
Author(s):  
Ira D. Davis ◽  
Katherine MacRae Dell ◽  
William E. Sweeney ◽  
Ellis D. Avner
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Recessive ◽  
Autosomal Dominant ◽  
Polycystic Kidney
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