Plasma lipoprotein (a) levels in children with minimal lesion nephrotic syndrome

1999 ◽  
Vol 13 (8) ◽  
pp. 657-661 ◽  
Author(s):  
C. Nakahara ◽  
Kimiko Kobayashi ◽  
Hideo Hamaguchi ◽  
Katsuyosi Kanemoto ◽  
Ryoichi Kashiwagi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Plasma Lipoprotein ◽  
Lipoprotein A ◽  
Minimal Lesion Nephrotic Syndrome

scholarly journals Prediction of Relapse by Plasma Lipoprotein(a) Concentration in Children with Steroid-Sensitive Nephrotic Syndrome

Nephron ◽  
2002 ◽  
Vol 92 (4) ◽  
pp. 807-811 ◽  
Author(s):  
Yukihiko Kawasaki ◽  
Junzo Suzuki ◽  
Ruriko Nozawa ◽  
Shigeo Suzuki ◽  
Hitoshi Suzuki
Keyword(s):  
Nephrotic Syndrome ◽  
Plasma Lipoprotein ◽  
Lipoprotein A ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive ◽  
Prediction Of Relapse

Differential effects of obesity with and without hyperinsulinemia on plasma lipoprotein(a) concentrations in men

Metabolism ◽  
2001 ◽  
Vol 50 (2) ◽  
pp. 178-183 ◽  
Author(s):  
Carlos Posadas-Romero ◽  
Antonio Hernández-Ono ◽  
José Zamora-González ◽  
Guillermo Cardoso-Saldaña ◽  
Liria Yamamoto-Kimura ◽  
...  
Keyword(s):  
Plasma Lipoprotein ◽  
Differential Effects ◽  
Lipoprotein A

Evidence for increased synthesis of lipoprotein(a) in the nephrotic syndrome.

1998 ◽  
Vol 9 (8) ◽  
pp. 1474-1481
Author(s):  
M G De Sain-Van Der Velden ◽  
D J Reijngoud ◽  
G A Kaysen ◽  
M M Gadellaa ◽  
H Voorbij ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Synthesis Rate ◽  
Fractional Synthesis Rate ◽  
Lipoprotein A ◽  
Control Subjects ◽  
Apolipoprotein A ◽  
Catabolic Rate ◽  
Fractional Synthesis ◽  
The Mean

In patients with the nephrotic syndrome, markedly increased levels of lipoprotein(a) (Lp(a)) concentration have been frequently reported, and it has been suggested that this may contribute to the increased cardiovascular risk in these patients. The mechanism, however, is not clear. In the present study, in vivo fractional synthesis rate of Lp(a) was measured using incorporation of the stable isotope 13C valine. Under steady-state conditions, fractional synthesis rate equals fractional catabolic rate (FCR). FCR of Lp(a) was estimated in five patients with the nephrotic syndrome and compared with five control subjects. The mean plasma Lp(a) concentration in the patients (1749+/-612 mg/L) was higher than in control subjects (553+/-96 mg/L). Two patients were heterozygous for apolipoprotein(a) (range, 19 to 30 kringle IV domains), whereas all control subjects were each homozygous with regard to apolipoprotein(a) phenotype (range, 18 to 28 kringle IV domains). The FCR of Lp(a) was comparable between control subjects (0.072+/-0.032 pools/d) and patients (0.064+/-0.029 pools/d) despite the wide variance in plasma concentration. This suggests that differences in Lp(a) levels are caused by differences in synthesis rate. Indeed, the absolute synthetic rate of Lp(a) correlated directly with plasma Lp(a) concentration (P < 0.0001) in all subjects. The present results demonstrate that increased synthesis, rather than decreased catabolism, causes elevated plasma Lp(a) concentrations in the nephrotic syndrome.

Plasma Lipoprotein(a) [LP(a)] Concentrations and Apoprotein(a) [APO(a)] Isoforms in Chronic Renal Disease

1997 ◽  
Vol 93 (s37) ◽  
pp. 13P-13P
Author(s):  
DA Reaveley ◽  
M Misra ◽  
N Al-Khalaf ◽  
E Brown ◽  
J Alaghband-Zadeh
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Plasma Lipoprotein ◽  
Lipoprotein A
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