Implications of intermittent calcitriol therapy on growth and secondary hyperparathyroidism

2000 ◽  
Vol 14 (7) ◽  
pp. 641-645 ◽  
Author(s):  
I. B. Salusky ◽  
W. G. Goodman ◽  
B. D. Kuizon
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Intermittent Calcitriol

scholarly journals Intermittent calcitriol therapy in secondary hyperparathyroidism: A comparison between oral and intraperitoneal administration

1998 ◽  
Vol 54 (3) ◽  
pp. 907-914 ◽  
Author(s):  
Isidro B. Salusky ◽  
Beatriz D. Kuizon ◽  
Thomas R. Belin ◽  
Jorge A. Ramirez ◽  
Barbara Gales ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Intraperitoneal Administration ◽  
Intermittent Calcitriol

Calcitriol therapy and calcium-regulated PTH secretion in patients with secondary hyperparathyroidism

1994 ◽  
Vol 267 (6) ◽  
pp. E961-E967 ◽  
Author(s):  
J. A. Ramirez ◽  
W. G. Goodman ◽  
T. R. Belin ◽  
B. Gales ◽  
G. V. Segre ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Dynamic Tests ◽  
Serum Parathyroid Hormone ◽  
Maximum Increase ◽  
Set Point ◽  
Parathyroid Function ◽  
Before And After ◽  
Intermittent Calcitriol ◽  
Serum Pth

Calcitriol lowers serum parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism, but its effect on calcium-regulated PTH release remains controversial. Thus 11 patients with secondary hyperparathyroidism underwent dynamic tests of parathyroid function before and after 4 mo of intermittent calcitriol therapy. Serum calcitriol levels rose from 8 +/- 1 to 55 +/- 9 (SE) pg/ml, P < 0.01, serum total and ionized calcium levels increased, and serum PTH levels decreased from 584 +/- 154 to 154 +/- 31 pg/ml, P < 0.05. The maximum increase in serum PTH during hypocalcemia did not differ before (248 +/- 78 pg/ml) or after (280 +/- 100 pg/ml) treatment, but the increase in PTH, expressed as a percentage of preinfusion values, was greater after treatment (329 +/- 73 vs. 132 +/- 10%, P < 0.05). The decreases in serum PTH during calcium infusions did not differ before (70 +/- 5%) or after (73 +/- 5%) therapy, and the set point for PTH release did not change (1.20 +/- 0.03 vs. 1.23 +/- 0.01 mmol/l, not significant). Calcitriol modifies PTH secretion during hypocalcemia in secondary hyperparathyroidism without affecting the set point for PTH release; although calcitriol lowers serum PTH levels, it may also restore the secretory reserve of hyperplastic parathyroid tissues during hypocalcemia.

Treatment of Secondary Hyperparathyroidism With Low Dose Intermittent Calcitriol in Hemodialysis Patients

ASAIO Journal ◽  
1995 ◽  
Vol 41 (3) ◽  
pp. M688-M693 ◽  
Author(s):  
Fulvio Susanna ◽  
Nicoletta Borsato ◽  
Barbara Rossi ◽  
Sergio Minello ◽  
Giorgio Ferlin ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Low Dose ◽  
Hemodialysis Patients ◽  
Intermittent Calcitriol

scholarly journals Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy

1994 ◽  
Vol 46 (4) ◽  
pp. 1160-1166 ◽  
Author(s):  
William G. Goodman ◽  
Jorge A. Ramirez ◽  
Thomas R. Belin ◽  
Yun Chon ◽  
Barbara Gales ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Adynamic Bone ◽  
Intermittent Calcitriol
Sign in / Sign up

Export Citation Format

Share Document