Transforming growth factors α and β-1 are co-expressed in the uterine epithelium during early pregnancy

2000 ◽  
Vol 300 (2) ◽  
pp. 315-320 ◽  
Author(s):  
Michael Slater ◽  
Christopher R. Murphy
Keyword(s):  
Growth Factors ◽  
Early Pregnancy ◽  
Uterine Epithelium ◽  
Transforming Growth Factors

scholarly journals Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression

Reproduction ◽  
2006 ◽  
Vol 132 (6) ◽  
pp. 939-947 ◽  
Author(s):  
S C Fernando ◽  
J S Buck ◽  
M D Ashworth ◽  
J W Ross ◽  
R D Geisert ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factors ◽  
Mrna Expression ◽  
Estrous Cycle ◽  
Early Pregnancy ◽  
Tissue Remodeling ◽  
Uterine Epithelium ◽  
Tissue Kallikrein ◽  
Rt Pcr

Previous studies have suggested that the porcine endometrium may express several tissue kallikreins during the estrous cycle and early pregnancy. The present study investigated porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 mRNA expression during the estrous cycle and early pregnancy. Tissue kallikrein (KLK) gene expression was evaluated using quantitative RT-PCR and in situ hybridization. KLK1 expression was similar across the estrous cycle and early pregnancy, and localized to the endometrial luminal (L) and glandular (G) epithelium. KLK4 endometrial mRNA expression was greatest on days 0, 5, and 10 when compared with days 12, 15, and 17 of the estrous cycle and greater in cyclic compared with pregnant gilts. Expression of KLK4 was more intense in the stroma and uterine epithelium from days 0 to 10 of the estrous cycle. Endometrial KLK11 mRNA was not different between cyclic and pregnant gilts but the expression was greatest on days 10 and 12 compared with all other days evaluated. There was an increased intensity of KLK11 gene expression in the stratum compactum on day 10 of the estrous cycle and early pregnancy. Endometrial KLK14 mRNA expression was not detectable on days 5 and 10 but was expressed on days 0, 12, 15, and 17 of the estrous cycle and pregnancy. KLK14 expression was localized in the uterine L and G epithelium, and stroma throughout the endometrium after day 10. Conceptus KLK1 mRNA did not change from days 10 to 17 of gestation. However, conceptus KLK4, and 14 mRNA expression was greatest on day 10 with expression declining after day 14 of gestation. Expression of the various tissue kallikreins in the endometrium and conceptus during the estrous cycle and early pregnancy in the pig can serve in the activation of growth factors and tissue remodeling during the establishment of pregnancy.

scholarly journals Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas

1997 ◽  
Vol 75 (12) ◽  
pp. 1753-1760 ◽  
Author(s):  
IE Eder ◽  
A Stenzl ◽  
A Hobisch ◽  
MV Cronauer ◽  
G Bartsch ◽  
...  
Keyword(s):  
Growth Factors ◽  
Transforming Growth Factors ◽  
Human Bladder ◽  
Beta 2 ◽  
Bladder Carcinomas

The Role of Transforming Growth Factors–Beta in Cutaneous Scarring

2000 ◽  
pp. 213-226 ◽  
Author(s):  
Mamta Shah ◽  
Patricia Rorison ◽  
Mark Ferguson
Keyword(s):  
Growth Factors ◽  
Transforming Growth Factors

scholarly journals PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT

2021 ◽  
Vol 27 (8) ◽  
pp. 779-782
Author(s):  
Wei Shen ◽  
Xiaojun Liang
Keyword(s):  
Gene Therapy ◽  
Growth Factors ◽  
Growth Factor ◽  
Physical Exercise ◽  
Fracture Healing ◽  
Bone Morphogenetic Protein ◽  
Bone Growth ◽  
Transforming Growth Factor ◽  
Transforming Growth Factors ◽  
Morphogenetic Protein

ABSTRACT Introduction: In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields. Objective: We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports. Methods: We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing. Results: In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage. Conclusion: Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.

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