Immunoultrastructural expression of intercellular adhesion molecule-1 in endothelial cell vesiculotubular structures and vesiculovacuolar organelles in blood-brain barrier development and injury

1999 ◽  
Vol 295 (1) ◽  
pp. 77 ◽  
Author(s):  
A. S. Lossinsky ◽  
K. F. Buttle ◽  
R. Pluta ◽  
M. J. Mossakowski ◽  
H. M. Wićniewski
Keyword(s):  
Endothelial Cell ◽  
Blood Brain Barrier ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Brain Barrier ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Blood Brain

Endothelial Cell Expression of Intercellular Adhesion Molecule 1 in Experimental Posthemorrhagic Vasospasm

Neurosurgery ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 453-461 ◽  
Author(s):  
Allen K. Sills ◽  
Richard E. Clatterbuck ◽  
Thompson Reid C. ◽  
Paul L. Cohen ◽  
Tamargo Rafael J.
Keyword(s):  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Cell Expression

scholarly journals Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 ◽  
Vol 107 (1) ◽  
pp. 321-331 ◽  
Author(s):  
M L Dustin ◽  
T A Springer
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Umbilical Vein ◽  
Peripheral Blood Lymphocytes ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Lymphocyte Function ◽  
Intercellular Adhesion Molecule 1 ◽  
Lymphocyte Adhesion

Intercellular adhesion molecule-1 (ICAM-1) on the surface of cultured umbilical vein and saphenous vein endothelial cells was upregulated between 2.5- and 40-fold by rIL-1, rTNF, LPS and rIFN gamma corresponding to up to 5 X 10(6) sites/cell. Endothelial cell ICAM-1 was a single band of 90 kD in SDS-PAGE. Purified endothelial cell ICAM-1 reconstituted into liposomes and bound to plastic was an excellent substrate for both JY B lymphoblastoid cell and T lymphoblast adhesion. Adhesion to endothelial cell ICAM-1 in planar membranes was blocked completely by monoclonal antibodies to lymphocyte function associated antigen-1 (LFA-1) or ICAM-1. Adhesion to artificial membranes was most sensitive to ICAM-1 density within the physiological range found on resting and stimulated endothelial cells. Adhesion of JY B lymphoblastoid cells, normal and genetically LFA-1 deficient T lymphoblasts and resting peripheral blood lymphocytes to endothelial cell monolayers was also assayed. In summary, LFA-1 dependent (60-90% of total adhesion) and LFA-1-independent basal adhesion was observed and the use of both adhesion pathways by different interacting cell pairs was increased by monokine or lipopolysaccharide stimulation of endothelial cells. The LFA-1-dependent adhesion could be further subdivided into an LFA-1/ICAM-1-dependent component which was increased by cytokines and a basal LFA-1-dependent, ICAM-1-independent component which did not appear to be affected by cytokines. We conclude that ICAM-1 is a regulated ligand for lymphocyte-endothelial cell adhesion, but at least two other major adhesion pathways exist.

Epigenetic Regulation of Tumor Endothelial Cell Anergy: Silencing of Intercellular Adhesion Molecule-1 by Histone Modifications

2006 ◽  
Vol 66 (22) ◽  
pp. 10770-10777 ◽  
Author(s):  
Debby M.E.I. Hellebrekers ◽  
Karolien Castermans ◽  
Emmanuelle Viré ◽  
Ruud P.M. Dings ◽  
Nicole T.H. Hoebers ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Histone Modifications ◽  
Adhesion Molecule ◽  
Epigenetic Regulation ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Tumor Endothelial Cell ◽  
Cell Anergy

Native LDL Increases Endothelial Cell Adhesiveness by Inducing Intercellular Adhesion Molecule–1

1996 ◽  
Vol 16 (4) ◽  
pp. 585-590 ◽  
Author(s):  
David M. Smalley ◽  
Jane H.-C. Lin ◽  
Michelle L. Curtis ◽  
Yukage Kobari ◽  
Michael B. Stemerman ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1
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