Pituitary adenylate cyclase-activating polypeptide in intrinsic and extrinsic nerves of the rat pancreas

2000 ◽  
Vol 299 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Jens Hannibal ◽  
Jan Fahrenkrug
Keyword(s):  
Adenylate Cyclase ◽  
Rat Pancreas ◽  
Pituitary Adenylate Cyclase ◽  
Extrinsic Nerves

Stimulatory effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on insulin and glucagon release from the isolated perfused rat pancreas

1993 ◽  
Vol 129 (5) ◽  
pp. 473-479 ◽  
Author(s):  
Chizuko Yokota ◽  
Koichi Kawai ◽  
Shinichi Ohashi ◽  
Yasuko Watanabe ◽  
Seiji Suzuki ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Insulin Release ◽  
Glucose Concentration ◽  
Dependent Manner ◽  
Glucagon Release ◽  
Perfused Rat Pancreas ◽  
Pancreas Perfusion ◽  
Rat Pancreas ◽  
Pituitary Adenylate Cyclase ◽  
Stimulation Of

Rat pancreas perfusion was performed to study the effects of pituitary adenylate cyclase activating polypeptide (PACAP) on pancreatic hormone release. Under the perfusate glucose concentration of 5.5 mmol/l, 0.1 nmol/l PACAP27 significantly stimulated both insulin and glucagon release. The degree of stimulation was in a dose dependent manner. The stimulation of insulin release was clearly dependent on the perfusate glucose concentration, when compared with 2.8, 5.5 and 8.3 mmol/l. The potency of PACAP38 on the stimulation of insulin release was greater than that of PACAP27 at 5.5 mmol/l of perfusate glucose concentration, but not at 8.3 mmol/l. No differences for glucagon and cAMP release were found between the two peptides. PACAP's stimulatory effects on insulin and glucagon release were completely abolished by an equimolar and ten times lower concentration of somatostatin, respectively. The physiologic significance of these potent effects of PACAP's islet hormones release must be clarified by further studies.

Pituitary adenylate cyclase activating polypeptide stimulates insulin release from the isolated perfused rat pancreas

Life Sciences ◽  
1992 ◽  
Vol 50 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Koichi Kawai ◽  
Chizuko Ohse ◽  
Yasuko Watanabe ◽  
Seiji Suzuki ◽  
Kamejiro Yamashita ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Insulin Release ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Pituitary Adenylate Cyclase

scholarly journals Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Mediating Insulin Secretion in Rodent Pancreatic Islets Are Coupled to Adenylate Cyclase But Not to PLC

Endocrinology ◽  
2002 ◽  
Vol 143 (4) ◽  
pp. 1253-1259 ◽  
Author(s):  
Francoise Jamen ◽  
Raymond Puech ◽  
Joel Bockaert ◽  
Philippe Brabet ◽  
Gyslaine Bertrand
Keyword(s):  
Insulin Secretion ◽  
Adenylate Cyclase ◽  
Pancreatic Islets ◽  
Pituitary Adenylate Cyclase

scholarly journals Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide.

1993 ◽  
Vol 268 (35) ◽  
pp. 26650-26657
Author(s):  
T Ohtaki ◽  
Y Masuda ◽  
Y Ishibashi ◽  
C Kitada ◽  
A Arimura ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Purification And Characterization ◽  
Pituitary Adenylate Cyclase
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