CD34 immunoreactivity and interstitial cells of Cajal in the human and mouse gastrointestinal tract

2000 ◽  
Vol 302 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Jean-Marie Vanderwinden ◽  
Jüri J. Rumessen ◽  
Marc-Henri De Laet ◽  
Jean-Jacques Vanderhaeghen ◽  
Serge N. Schiffmann
Keyword(s):  
Gastrointestinal Tract ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Cells Of Cajal ◽  
Human And Mouse

Region-specific distribution of the P2Y4 receptor in enteric glial cells and interstitial cells of Cajal within the guinea-pig gastrointestinal tract

2006 ◽  
Vol 126-127 ◽  
pp. 299-306 ◽  
Author(s):  
Luc Van Nassauw ◽  
Anna Costagliola ◽  
Joeri Van Op den Bosch ◽  
Aldo Cecio ◽  
Jean-Marie Vanderwinden ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Guinea Pig ◽  
Glial Cells ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Specific Distribution ◽  
Enteric Glial Cells ◽  
Cells Of Cajal ◽  
P2y4 Receptor

A Novel Pacemaker Mechanism Drives Gastrointestinal Rhythmicity

Physiology ◽  
2000 ◽  
Vol 15 (6) ◽  
pp. 291-298 ◽  
Author(s):  
Kenton M. Sanders ◽  
Tamás Ördög ◽  
Sang Don Koh ◽  
Sean M. Ward
Keyword(s):  
Endoplasmic Reticulum ◽  
Gastrointestinal Tract ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Pacemaker Activity ◽  
Cation Conductance ◽  
Inward Currents ◽  
Cells Of Cajal ◽  
Pacemaker Currents

Electric pacemaker activity drives peristaltic and segmental contractions in the gastrointestinal tract. Interstitial cells of Cajal (ICC) are responsible for spontaneous pacemaker activity. ICC remain rhythmic in culture and generate voltage-independent inward currents via a nonselective cation conductance. Ca2+ release from endoplasmic reticulum and uptake by mitochondria initiates pacemaker currents. This novel mechanism provides the basis for electric rhythmicity in gastrointestinal muscles.

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