scholarly journals Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields

2021 ◽  
Author(s):  
Gianfranco Giorgi ◽  
Brunella Del Re
Keyword(s):  
Magnetic Fields ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Expression Patterns ◽  
Low Frequency ◽  
Cell Types ◽  
International Agency ◽  
Epigenetic Alterations ◽  
Extremely Low Frequency ◽  
Number Of Publications

AbstractEpigenetic mechanisms regulate gene expression, without changing the DNA sequence, and establish cell-type-specific temporal and spatial expression patterns. Alterations of epigenetic marks have been observed in several pathological conditions, including cancer and neurological disorders. Emerging evidence indicates that a variety of environmental factors may cause epigenetic alterations and eventually influence disease risks. Humans are increasingly exposed to extremely low-frequency magnetic fields (ELF-MFs), which in 2002 were classified as possible carcinogens by the International Agency for Research on Cancer. This review summarizes the current knowledge of the link between the exposure to ELF-MFs and epigenetic alterations in various cell types. In spite of the limited number of publications, available evidence indicates that ELF-MF exposure can be associated with epigenetic changes, including DNA methylation, modifications of histones and microRNA expression. Further research is needed to investigate the molecular mechanisms underlying the observed phenomena.

scholarly journals Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

2021 ◽  
Vol 22 (7) ◽  
pp. 3772
Author(s):  
David Schuermann ◽  
Meike Mevissen
Keyword(s):  
Oxidative Stress ◽  
Electromagnetic Fields ◽  
Communication Systems ◽  
Genome Stability ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Experimental Studies ◽  
Low Frequency ◽  
International Agency ◽  
Extremely Low Frequency

Concomitant with the ever-expanding use of electrical appliances and mobile communication systems, public and occupational exposure to electromagnetic fields (EMF) in the extremely-low-frequency and radiofrequency range has become a widely debated environmental risk factor for health. Radiofrequency (RF) EMF and extremely-low-frequency (ELF) MF have been classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). The production of reactive oxygen species (ROS), potentially leading to cellular or systemic oxidative stress, was frequently found to be influenced by EMF exposure in animals and cells. In this review, we summarize key experimental findings on oxidative stress related to EMF exposure from animal and cell studies of the last decade. The observations are discussed in the context of molecular mechanisms and functionalities relevant to health such as neurological function, genome stability, immune response, and reproduction. Most animal and many cell studies showed increased oxidative stress caused by RF-EMF and ELF-MF. In order to estimate the risk for human health by manmade exposure, experimental studies in humans and epidemiological studies need to be considered as well.

scholarly journals The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system

2012 ◽  
Vol 14 (4) ◽  
pp. 381-399 ◽  
Keyword(s):  
Magnetic Fields ◽  
Childhood Leukemia ◽  
Low Frequency ◽  
Health Concern ◽  
International Agency ◽  
Extremely Low Frequency ◽  
The Past ◽  
Melatonin Production ◽  
Leukemia In Children

In the past 30 years the concern that daily exposure to extremely low-frequency magnetic fields (ELF-EMF) (1 to 300 Hz) might be harmful to human health (cancer, neurobehavioral disturbances, etc) has been the object of debate, and has become a public health concern. This has resulted in the classification of ELF-EMF into category 2B, ie, agents that are "possibly carcinogenic to humans" by the International Agency for Research on Cancer. Since melatonin, a neurohormone secreted by the pineal gland, has been shown to possess oncostatic properties, a "melatonin hypothesis" has been raised, stating that exposure to EMF might decrease melatonin production and therefore might promote the development of breast cancer in humans. Data from the literature reviewed here are contradictory. In addition, we have demonstrated a lack of effect of ELF-EMF on melatonin secretion in humans exposed to EMF (up to 20 years' exposure) which rebuts the melatonin hypothesis. Currently, the debate concerns the effects of ELF-EMF on the risk of childhood leukemia in children chronically exposed to more than 0.4 μT. Further research is thus needed to obtain more definite answers regarding the potential deleterious effects of ELF-EMF.

The characteristics and present state for Extremely Low Frequency-Magnetic Fields of metropolitan subway

2015 ◽  
Vol 14 (1) ◽  
pp. 7-15
Author(s):  
Dae-kwan Jung ◽  
◽  
Joon-sig Jung ◽  
Kyu-mok Lee ◽  
Hyung-kyu Park ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Present State ◽  
Low Frequency ◽  
Extremely Low Frequency

Occupational Exposure to Electric Shocks and Extremely Low-Frequency Magnetic Fields and Motor Neurone Disease

2020 ◽  
Author(s):  
Grace X Chen ◽  
Andrea’t Mannetje ◽  
Jeroen Douwes ◽  
Leonard H Berg ◽  
Neil Pearce ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Magnetic Fields ◽  
Low Frequency ◽  
Population Based ◽  
Motor Neurone ◽  
Motor Neurone Disease ◽  
Cumulative Exposure ◽  
Spine Injury ◽  
Extremely Low Frequency ◽  
Electric Shocks

Abstract In a New Zealand population-based case-control study we assessed associations with occupational exposure to electric shocks, extremely low-frequency magnetic fields (ELF-MF) and motor neurone disease using job-exposure matrices to assess exposure. Participants were recruited between 2013 and 2016. Associations with ever/never, duration, and cumulative exposure were assessed using logistic regression adjusted for age, sex, ethnicity, socioeconomic status, education, smoking, alcohol consumption, sports, head or spine injury and solvents, and mutually adjusted for the other exposure. All analyses were repeated stratified by sex. An elevated risk was observed for having ever worked in a job with potential for electric shocks (odds ratio (OR)=1.35, 95% confidence interval (CI): 0.98, 1.86), with the strongest association for the highest level of exposure (OR=2.01, 95%CI: 1.31, 3.09). Analysis by duration suggested a non-linear association: risk was increased for both short-duration (<3 years) (OR= 4.69, 95%CI: 2.25, 9.77) and long-duration in a job with high level of electric shock exposure (>24 years; OR=1.88; 95%CI: 1.05, 3.36), with less pronounced associations for intermediate durations. No association with ELF-MF was found. Our findings provide support for an association between occupational exposure to electric shocks and motor neurone disease but did not show associations with exposure to work-related ELF-MF.

Effects of extremely low frequency magnetic fields on pain thresholds in mice: roles of melatonin and opioids

2000 ◽  
Vol 20 (4) ◽  
pp. 259-264 ◽  
Author(s):  
J. H. Jeong ◽  
K. B. Choi ◽  
B. C. Yi ◽  
C. H. Chun ◽  
K.-Y. Sung ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Low Frequency ◽  
Pain Thresholds ◽  
Extremely Low Frequency
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