Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase

2014 ◽  
Vol 359 (1) ◽  
pp. 201-213 ◽  
Author(s):  
Eric Agius ◽  
Sophie Bel-Vialar ◽  
Frédéric Bonnet ◽  
Fabienne Pituello
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Cell Fate ◽  
Developing Nervous System

scholarly journals Co-ordination of cell cycle and differentiation in the developing nervous system

2012 ◽  
Vol 444 (3) ◽  
pp. 375-382 ◽  
Author(s):  
Christopher Hindley ◽  
Anna Philpott
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Embryonic Development ◽  
Cell Fate ◽  
Cell Cycle Progression ◽  
Control Cell ◽  
Cell Cycle Regulators ◽  
Cyclin Dependent Kinases ◽  
Proliferation And Differentiation ◽  
Developing Nervous System

During embryonic development, cells must divide to produce appropriate numbers, but later must exit the cell cycle to allow differentiation. How these processes of proliferation and differentiation are co-ordinated during embryonic development has been poorly understood until recently. However, a number of studies have now given an insight into how the cell cycle machinery, including cyclins, CDKs (cyclin-dependent kinases), CDK inhibitors and other cell cycle regulators directly influence mechanisms that control cell fate and differentiation. Conversely, examples are emerging of transcriptional regulators that are better known for their role in driving the differentiated phenotype, which also play complementary roles in controlling cell cycle progression. The present review will summarise our current understanding of the mechanisms co-ordinating the cell cycle and differentiation in the developing nervous system, where these links have been, perhaps, most extensively studied.

Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes

Development ◽  
2001 ◽  
Vol 128 (5) ◽  
pp. 711-722 ◽  
Author(s):  
T.E. Rusten ◽  
R. Cantera ◽  
J. Urban ◽  
G. Technau ◽  
F.C. Kafatos ◽  
...  
Keyword(s):  
Nervous System ◽  
Cell Fate ◽  
System Development ◽  
Cell Types ◽  
Nervous System Development ◽  
Dual Function ◽  
Evolutionarily Conserved ◽  
A Cell ◽  
And Migration

Genes of the spalt family encode nuclear zinc finger proteins. In Drosophila melanogaster, they are necessary for the establishment of head/trunk identity, correct tracheal migration and patterning of the wing imaginal disc. Spalt proteins display a predominant pattern of expression in the nervous system, not only in Drosophila but also in species of fish, mouse, frog and human, suggesting an evolutionarily conserved role for these proteins in nervous system development. Here we show that Spalt works as a cell fate switch between two EGFR-induced cell types, the oenocytes and the precursors of the pentascolopodial organ in the embryonic peripheral nervous system. We show that removal of spalt increases the number of scolopodia, as a result of extra secondary recruitment of precursor cells at the expense of the oenocytes. In addition, the absence of spalt causes defects in the normal migration of the pentascolopodial organ. The dual function of spalt in the development of this organ, recruitment of precursors and migration, is reminiscent of its role in tracheal formation and of the role of a spalt homologue, sem-4, in the Caenorhabditis elegans nervous system.

Intrinsic and Extrinsic Determinants Regulating Cell Fate Decision in Developing Nervous System

1997 ◽  
Vol 19 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Masataka Okabe ◽  
Kazunobu Sawamoto ◽  
Takao Imai ◽  
Shin-ichi Sakakibara ◽  
Shingo Yoshikawa ◽  
...  
Keyword(s):  
Nervous System ◽  
Cell Fate ◽  
Cell Fate Decision ◽  
Fate Decision ◽  
Developing Nervous System

scholarly journals Neurotrophin, p75, and Trk Signaling Module in the Developing Nervous System of the Marine AnnelidPlatynereis dumerilii

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Antonella Lauri ◽  
Paola Bertucci ◽  
Detlev Arendt
Keyword(s):  
Nervous System ◽  
Neuronal Development ◽  
Neural Circuit ◽  
Circuit Development ◽  
Circuit Formation ◽  
Neurotrophic Signaling ◽  
High Degree ◽  
Developing Nervous System

In vertebrates, neurotrophic signaling plays an important role in neuronal development, neural circuit formation, and neuronal plasticity, but its evolutionary origin remains obscure. We found and validated nucleotide sequences encoding putative neurotrophic ligands (neurotrophin, NT) and receptors (Trk and p75) in two annelids,Platynereis dumerilii(Errantia) andCapitella teleta(Sedentaria, for which some sequences were found recently by Wilson, 2009). Predicted protein sequences and structures ofPlatynereisneurotrophic molecules reveal a high degree of conservation with the vertebrate counterparts; some amino acids signatures present in the annelid Trk sequences are absent in the basal chordate amphioxus, reflecting secondary loss in the cephalochordate lineage. In addition, expression analysis of NT, Trk, and p75 duringPlatynereisdevelopment by whole-mount mRNAin situhybridization supports a role of these molecules in nervous system and circuit development. These annelid data corroborate the hypothesis that the neurotrophic signaling and its involvement in shaping neural networks predate the protostome-deuterostome split and were present in bilaterian ancestors.

scholarly journals aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Matthew Robert Hannaford ◽  
Anne Ramat ◽  
Nicolas Loyer ◽  
Jens Januschke
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Plasma Membrane ◽  
Nuclear Envelope ◽  
Cell Fate ◽  
Progenitor Cell ◽  
Adapter Protein ◽  
Unequal Distribution ◽  
Nuclear Envelope Breakdown ◽  
Differential Binding

Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell division. We address asymmetric fate determinant localization in the developing Drosophila nervous system, specifically the control of the polarized distribution of the cell fate adapter protein Miranda. We reveal a step-wise polarization of Miranda in larval neuroblasts and find that Miranda’s dynamics and cortical association are differently regulated between interphase and mitosis. In interphase, Miranda binds to the plasma membrane. Then, before nuclear envelope breakdown, Miranda is phosphorylated by aPKC and displaced into the cytoplasm. This clearance is necessary for the subsequent establishment of asymmetric Miranda localization. After nuclear envelope breakdown, actomyosin activity is required to maintain Miranda asymmetry. Therefore, phosphorylation by aPKC and differential binding to the actomyosin network are required at distinct phases of the cell cycle to polarize fate determinant localization in neuroblasts.

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