Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12-q13

2000 ◽  
Vol 106 (1) ◽  
pp. 58-65 ◽  
Author(s):  
M. Takahashi ◽  
E. Rapley ◽  
P.J. Biggs ◽  
S.R Lakhani ◽  
D. Cooke ◽  
...  
Keyword(s):  
Genetic Heterogeneity ◽  
Chromosome 16Q12

Cell Wall Ultrastructure in Three Strains of a Cariogenic Streptococcus

1971 ◽  
Vol 29 ◽  
pp. 338-339
Author(s):  
M. J. Kramer ◽  
Alan L. Coykendall
Keyword(s):  
Cell Wall ◽  
Dental Caries ◽  
Streptococcus Mutans ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Genetic Heterogeneity ◽  
Morphological Characteristics ◽  
Electron Microscopic ◽  
Dna Reassociation ◽  
Wall Ultrastructure

During the almost 50 years since Streptococcus mutans was first suggested as a factor in the etiology of dental caries, a multitude of studies have confirmed the cariogenic potential of this organism. Streptococci have been isolated from human and animal caries on numerous occasions and, with few exceptions, they are not typable by the Lancefield technique but are relatively homogeneous in their biochemical reactions. An analysis of the guanine-cytosine (G-C) composition of the DNA from strains K-1-R, NCTC 10449, and FA-1 by one of us (ALC) revealed significant differences and DNA-DNA reassociation experiments indicated that genetic heterogeneity existed among the three strains. The present electron microscopic study had as its objective the elucidation of any distinguishing morphological characteristics which might further characterize the respective strains.

Genetic Heterogeneity of Heart-Hand Syndromes

Circulation ◽  
1995 ◽  
Vol 91 (5) ◽  
pp. 1326-1329 ◽  
Author(s):  
Craig T. Basson ◽  
Scott D. Solomon ◽  
Barbara Weissman ◽  
Calum A. MacRae ◽  
Andrew K. Poznanski ◽  
...  
Keyword(s):  
Genetic Heterogeneity

GENETIC HETEROGENEITY OF RABBIT ALPHA-1-ANTITRYPSIN

Genetics ◽  
1984 ◽  
Vol 106 (4) ◽  
pp. 695-703
Author(s):  
F Kueppers ◽  
C C Lee ◽  
R R Fox ◽  
J K Mills
Keyword(s):  
Sexual Dimorphism ◽  
Genetic Heterogeneity ◽  
Inbred Strains ◽  
Quantitative Variation ◽  
Moderate Degree ◽  
Inhibiting Activity ◽  
Interindividual Differences ◽  
Alpha 1 Antitrypsin ◽  
Serum Trypsin

ABSTRACT Sixteen inbred or partially inbred strains of rabbits were investigated for electrophoretic and quantitative variations of alpha-1-antitrypsin (A-1-AT). We found interindividual differences in the electrophoretic A-1-AT patterns as well as quantitative differences in the concentrations of A-1-AT and the serum trypsin-inhibiting activity. Three electrophoretic phenotypes were distinguished: M, P and MP. M was characterized by a predominant anodal A-1-AT band, and P had a major cathodal component. The MP pattern can be explained by the occurrence of the M and P components in the same serum due to heterozygosity. The P pattern was associated with an A-1-AT concentration of approximately 56% of that in sera with the M phenotype. The levels of A-1-AT in sera with the MP phenotype were intermediate between those in M and P types. In addition to the type-specific quantitative variation, we found a quantitative sexual dimorphism of a moderate degree: Female rabbits had A-1-AT concentrations 16% less than males.

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