Extent of linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in human populations: implications for prostate cancer risk

2001 ◽  
Vol 109 (3) ◽  
pp. 253-261 ◽  
Author(s):  
Rick A. Kittles ◽  
Dale Young ◽  
Sally Weinrich ◽  
Julie Hudson ◽  
George Argyropoulos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Linkage Disequilibrium ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Human Populations

scholarly journals Cag Repeat Number in the Androgen Receptor Gene and Prostate Cancer

2012 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
S Madjunkova ◽  
A Eftimov ◽  
V Georgiev ◽  
D Petrovski ◽  
A Dimovski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Repeat Number

Cag Repeat Number in the Androgen Receptor Gene and Prostate CancerProstate cancer (PC) is the second leading cause of cancer deaths in men. The effects of androgens on prostatic tissue are mediated by the androgen receptor (AR) gene. The 5' end of exon 1 of the AR gene includes a polymorphic CAG triplet repeat that numbers between 10 to 36 in the normal population. The length of the CAG repeats is inversely related to the transactivation function of the AR gene. There is controversy over association between short CAG repeat numbers in the AR gene and PC. This retrospective case-control study evaluates the possible effect of short CAG repeats on the AR gene in prostate cancer risk in Macedonian males. A total of 392 male subjects, 134 PC patients, 106 patients with benign prostatic hyperplasia (BPH) and 152 males from the general Macedonian population were enrolled in this study. The CAG repeat length was determined by fluorescent polymerase chain reaction (PCR) amplification of exon1 of the AR gene followed by capillary electrophoresis (CE) on a genetic analyzer. The mean repeat length in PC patients was 21.5 ±2.65, in controls 22.28 ±2.86 (p = 0.009) and in BPH patients 22.1 ±2.52 (p = 0.038). Short CAG repeats (<19) were found in 21.64% of PC patients vs. 9.43% in BPH patients (p = 0.0154). We also found an association of low Gleason score (<7) with short CAG repeat (<19) in PC patients (p = 0.0306), and no association between the age at diagnosis of PC and BPH and CAG repeat length. These results suggest that reduced CAG repeat length may be associated with increased prostate cancer risk in Macedonian men.

scholarly journals GGN repeat length and GGN/CAG haplotype variations in the androgen receptor gene and prostate cancer risk in south Indian men

2006 ◽  
Vol 51 (11) ◽  
pp. 998-1005 ◽  
Author(s):  
Krishnaswamy Vijayalakshmi ◽  
Kumarasamy Thangaraj ◽  
Singh Rajender ◽  
Venkatesan Vettriselvi ◽  
Perumal Venkatesan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
South Indian ◽  
Indian Men

Polymorphic CAG and GGC Repeat Lengths in the Androgen Receptor Gene and Prostate Cancer Risk: Analysis of a Brazilian Population

2008 ◽  
Vol 26 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Brasil Silva Neto ◽  
Walter J. Koff ◽  
Vanderlei Biolchi ◽  
Cleber Brenner ◽  
Karlo D. Biolo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Risk Analysis ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Brazilian Population

Tandem CAG Repeats of the Androgen Receptor Gene and Prostate Cancer Risk in Black and White Men

Endocrine ◽  
2001 ◽  
Vol 15 (2) ◽  
pp. 213-216 ◽  
Author(s):  
Vanessa R Panz ◽  
Barry I Joffe ◽  
Irving Spitz ◽  
Tzina Lindenberg ◽  
Amicur Farkas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
White Men ◽  
Androgen Receptor Gene ◽  
Cag Repeats ◽  
Black And White

Association Among an Ornithine Decarboxylase Polymorphism, Androgen Receptor Gene (CAG) Repeat Length and Prostate Cancer Risk

2004 ◽  
Vol 171 (2) ◽  
pp. 652-655 ◽  
Author(s):  
KALA VISVANATHAN ◽  
KATHY J. HELZLSOUER ◽  
DAVID W. BOORMAN ◽  
PAUL T. STRICKLAND ◽  
SANDY C. HOFFMAN ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Ornithine Decarboxylase ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat

Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk

2002 ◽  
Vol 110 (2) ◽  
pp. 122-129 ◽  
Author(s):  
Bao-li Chang ◽  
Siqun L. Zheng ◽  
Gregory A. Hawkins ◽  
Sarah D. Isaacs ◽  
Kathy E. Wiley ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene
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