Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis

1999 ◽  
Vol 105 (3) ◽  
pp. 253-257 ◽  
Author(s):  
S.C. Hunt ◽  
H. Orimo ◽  
Y. Shirai ◽  
M. Emi ◽  
N. Ota ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Sibling Pair ◽  
Pair Analysis

Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis

1999 ◽  
Vol 105 (3) ◽  
pp. 253-257 ◽  
Author(s):  
N. Ota ◽  
S.C. Hunt ◽  
T. Nakajima ◽  
T. Suzuki ◽  
T. Hosoi ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Sibling Pair ◽  
Pair Analysis

scholarly journals Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e043202
Author(s):  
Masafumi Sanefuji ◽  
Ayako Senju ◽  
Masayuki Shimono ◽  
Masanobu Ogawa ◽  
Yuri Sonoda ◽  
...  
Keyword(s):  
Developmental Delay ◽  
Breast Feeding ◽  
Risk Ratio ◽  
Infant Development ◽  
Primary Outcome ◽  
Sibling Pair ◽  
Regression Analyses ◽  
Adjusted Risk ◽  
Adjusted Risk Ratio ◽  
Pair Analysis

ObjectivesTo investigate the association between breast feeding and infant development during the first year of life using sibling comparison.DesignNationwide prospective birth cohort study with sibling pair analysis.Setting15 regional centres that participated in the Japan Environment and Children’s Study.ParticipantsThis study included 77 119 children (singleton, term birth and no malformation/severe diseases) whose mothers were registered between January 2011 and March 2014, including 3521 duos or trios of siblings.Primary outcome measuresThe primary outcome was developmental delay at 6 and 12 months of age, assessed using the Japanese translation of the Ages and Stages Questionnaires, third edition. Multivariable regression analyses adjusted for confounders were performed to estimate the risk ratios of delay associated with any or exclusive breast feeding. Pairs of siblings discordant for statuses were selected, and conditional regression analyses were conducted with a matched cohort design.ResultsDevelopmental delay was identified in 6162 (8.4%) and 10 442 (14.6%) children at 6 and 12 months of age, respectively. Any breast feeding continued until 6 months or 12 months old was associated with reduced developmental delay at 12 months of age (adjusted risk ratio (95% CI): 0.81 (0.77 to 0.85) and 0.81 (0.78 to 0.84), respectively). Furthermore, exclusive breast feeding until 3 months was associated with reduced developmental delay at 12 months of age (adjusted risk ratio, 0.86 (95% CI 0.83 to 0.90)). In sibling pair analysis, the association between any breast feeding until 12 months and reduced developmental delay at 12 months of age persisted (adjusted risk ratio, 0.64 (95% CI 0.43 to 0.93)).ConclusionsThe present study demonstrated the association of continuous breast feeding with reduced developmental delay at 1 year of age using sibling pair analysis, in which unmeasured confounding factors are still present but less included. This may provide an argument to promote breastfeeding continuation.

scholarly journals Impact of Maternal Obesity on Inhaled Corticosteroid Use in Childhood: A Registry Based Analysis of First Born Children and a Sibling Pair Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e67368 ◽  
Author(s):  
Adrian J. Lowe ◽  
Cecilia Ekeus ◽  
Lennart Bråbäck ◽  
Kristiina Rajaleid ◽  
Bertil Forsberg ◽  
...  
Keyword(s):  
Maternal Obesity ◽  
Sibling Pair ◽  
Inhaled Corticosteroid ◽  
Pair Analysis

An Examination of Linkage of Schizophrenia and Schizoaffective Disorder to the Pseudoautosomal Region (Xp22.3)

1994 ◽  
Vol 164 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Timothy J. Crow ◽  
Lynn E. Delisi ◽  
Raymond Lofthouse ◽  
Mark Poulter ◽  
Thomas Lehner ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Schizoaffective Disorder ◽  
Recombination Fraction ◽  
Sibling Pair ◽  
Pseudoautosomal Region ◽  
Dominant Model ◽  
Lod Score ◽  
Y Chromosomes ◽  
Pair Analysis

We investigated linkage between schizophrenia and the loci DXYS14, DXYS17, and MIC2 within the pseudoautosomal region in 85 families with two or more siblings suffering from schizophrenia or schizoaffective disorder. A maximum lod score of 2.44 was reached at MIC2, with a dominant model of inheritance at a recombination fraction of 0.367 in females and 0.046 in males (a F: M sex ratio > 1, i.e. opposite to that expected with a pseudoautosomal locus). Evidence consistent with linkage (P = 0.01) was also obtained with a sibling pair analysis at the MIC2 locus. These data do not support (although they do not definitively exclude) a locus within the pseudoautosomal region; they are consistent with the presence of a gene that predisposes to schizophrenia in the sex-specific regions of the X and Y chromosomes.

scholarly journals Association Between Cannabis Use and Psychosis-Related Outcomes Using Sibling Pair Analysis in a Cohort of Young Adults

2010 ◽  
Vol 67 (5) ◽  
pp. 440 ◽  
Author(s):  
John McGrath ◽  
Joy Welham ◽  
James Scott ◽  
Daniel Varghese ◽  
Louisa Degenhardt ◽  
...  
Keyword(s):  
Young Adults ◽  
Cannabis Use ◽  
Sibling Pair ◽  
Pair Analysis

A Sibling-Pair Analysis of Fasting Lipids and Anthropometric Measurements and Their Relationship to Hypertension

1999 ◽  
Vol 21 (7) ◽  
pp. 1161-1176 ◽  
Author(s):  
G Neil Thomas ◽  
Robert P Young ◽  
Brian Tomlinson ◽  
Patricia J Anderson ◽  
Kam Sang Woo ◽  
...  
Keyword(s):  
Anthropometric Measurements ◽  
Sibling Pair ◽  
Pair Analysis
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