Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene

1996 ◽  
Vol 98 (3) ◽  
pp. 259-264 ◽  
Author(s):  
O. Windl ◽  
Maureen Dempster ◽  
J. Peter Estibeiro ◽  
Richard Lathe ◽  
Rajith de Silva ◽  
...  
Keyword(s):  
United Kingdom ◽  
Genetic Basis ◽  
Allelic Variation ◽  
Prnp Gene ◽  
Systematic Analysis ◽  
The United Kingdom ◽  
Jakob Disease

scholarly journals Latest quarterly analysis of variant Creutzfeldt-Jakob disease incidence in the UK shows continued slow-down

2003 ◽  
Vol 7 (18) ◽  
Author(s):  
N J Andrews
Keyword(s):  
United Kingdom ◽  
Disease Incidence ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk

Five new cases of variant Creutzfeldt-Jakob disease (vCJD) were diagnosed in the United Kingdom (UK) in the first quarter of 2003, bringing the total number of confirmed or probable cases to 134 (1). Five deaths occurred in the first quarter, bringing the total number of deaths to 126. The total number of onsets and deaths by year are shown in the table.

scholarly journals Variant Creutzfeldt-Jakob disease in the United Kingdom and elsewhere: situation at the end of 2005

2006 ◽  
Vol 11 (4) ◽  
Author(s):  
A M Molesworth ◽  
N J Andrews
Keyword(s):  
United Kingdom ◽  
The United Kingdom ◽  
Jakob Disease

By the end of December 2005, a total of 159 cases of variant Creutzfeldt-Jakob disease (vCJD) had been reported in the United Kingdom, of which 153 have so far resulted in death.

scholarly journals Two-Year Systematic Study To Assess Norovirus Contamination in Oysters from Commercial Harvesting Areas in the United Kingdom

2012 ◽  
Vol 78 (16) ◽  
pp. 5812-5817 ◽  
Author(s):  
James A. Lowther ◽  
Nicole E. Gustar ◽  
Andrew L. Powell ◽  
Rachel E. Hartnell ◽  
David N. Lees
Keyword(s):  
United Kingdom ◽  
Systematic Study ◽  
Quantitative Methods ◽  
Human Health Risk ◽  
Risk Indicators ◽  
The European Union ◽  
Systematic Analysis ◽  
The United Kingdom ◽  
Production Areas ◽  
The Impact

ABSTRACTThe contamination of bivalve shellfish with norovirus from human fecal sources is recognized as an important human health risk. Standardized quantitative methods for the detection of norovirus in molluscan shellfish are now available, and viral standards are being considered in the European Union and internationally. This 2-year systematic study aimed to investigate the impact of the application of these methods to the monitoring of norovirus contamination in oyster production areas in the United Kingdom. Twenty-four monthly samples of oysters from 39 United Kingdom production areas, chosen to represent a range of potential contamination risk, were tested for norovirus genogroups I and II by using a quantitative real-time reverse transcription (RT)-PCR method. Norovirus was detected in 76.2% (643/844) of samples, with all sites returning at least one positive result. Both prevalences (presence or absence) and norovirus levels varied markedly between sites. However, overall, a marked winter seasonality of contamination by both prevalence and quantity was observed. Correlations were found between norovirus contamination and potential risk indicators, including harvesting area classifications,Escherichia coliscores, and environmental temperatures. A predictive risk score for norovirus contamination was developed by using a combination of these factors. In summary, this study, the largest of its type undertaken to date, provides a systematic analysis of norovirus contamination in commercial oyster production areas in the United Kingdom. The data should assist risk managers to develop control strategies to reduce the risk of human illness resulting from norovirus contamination of bivalve molluscs.

scholarly journals Surveillance of Creutzfeldt Jakob disease in the United Kingdom

2000 ◽  
Vol 5 (9) ◽  
pp. 90-94 ◽  
Author(s):  
H J T Ward
Keyword(s):  
United Kingdom ◽  
The United Kingdom ◽  
Jakob Disease ◽  
Surveillance Unit ◽  
Set Up ◽  
Codon 129

By the end of May 2000, 54 definite cases and 13 probable cases of vCJD had been notified in the United Kingdom by the National CJD Surveillance Unit set up in 1990. All definite cases for whom data are available are methionine homozygous at codon 129 of

scholarly journals Possible case of transfusion-associated variant CJD in the United Kingdom

2003 ◽  
Vol 7 (51) ◽  
Author(s):  
Keyword(s):  
United Kingdom ◽  
Blood Transfusion ◽  
The United Kingdom ◽  
First Case ◽  
Jakob Disease

The first case of variant Creutzfeldt-Jakob disease (vCJD) thought to have been infected via a blood transfusion may have been seen in the United Kingdom

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