The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: an analysis of 618 individuals

1996 ◽  
Vol 98 (2) ◽  
pp. 176-177 ◽  
Author(s):  
Y.-L. Ko ◽  
Tsu-Shiu Hsu ◽  
Shy-Meeng Wu ◽  
Yu-Shien Ko ◽  
Chi-Jen Chang ◽  
...  
Keyword(s):  
Factor V Leiden ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

scholarly journals Factor V Kuwait: A Novel Mutation in the Coagulation Factor V Gene Discovered in Kuwait

2006 ◽  
Vol 15 (2) ◽  
pp. 102-105
Author(s):  
Mehrez M. Jadaon ◽  
Ali A. Dashti ◽  
Hend L. Lewis
Keyword(s):  
Novel Mutation ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

Expression of coagulation factor V gene by normal adult human hepatocytes in primary culture

1991 ◽  
Vol 78 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Marlene Mazzorana ◽  
Georges Baffet ◽  
Bernard Kneip ◽  
Bernard Launois ◽  
Christiane Guguen-Guillouzo
Keyword(s):  
Primary Culture ◽  
Coagulation Factor ◽  
Human Hepatocytes ◽  
Normal Adult ◽  
Factor V ◽  
Adult Human ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

Studies on phospholipid antibodies, APC-resistance and associated mutation in the coagulation factor V gene

1995 ◽  
Vol 78 (3) ◽  
pp. 193-200 ◽  
Author(s):  
Maria I. Bokarewa ◽  
Katarina Bremme ◽  
Gunnar Falk ◽  
Margareta Sten-Linder ◽  
Nils Egberg ◽  
...  
Keyword(s):  
Coagulation Factor ◽  
Factor V ◽  
Apc Resistance ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

Arg506Gln mutation of the coagulation factor V gene not detected in Japanese pulmonary thromboembolism

1998 ◽  
Vol 13 (4) ◽  
pp. 195-198 ◽  
Author(s):  
Takafumi Seki ◽  
Hiroshi Okayama ◽  
Tomoko Kumagai ◽  
Norihisa Kumasaka ◽  
Masahito Sakuma ◽  
...  
Keyword(s):  
Pulmonary Thromboembolism ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

New missense mutation in exon 13 (N789T) of the coagulation factor V gene

1999 ◽  
Vol 14 (4) ◽  
pp. 357-357 ◽  
Author(s):  
H. Kostka ◽  
G. Siegert ◽  
S. Gehrisch ◽  
E. Kuhlisch ◽  
E. Runge ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

New Coagulation Factor V Gene Polymorphisms Define a Single and Infrequent Haplotype Underlying the Factor V Leiden Mutation in Mediterranean Populations and Indians

1997 ◽  
Vol 78 (03) ◽  
pp. 1037-1041 ◽  
Author(s):  
E Castoldi ◽  
B Lunghi ◽  
F Mingozzi ◽  
P Loannou ◽  
G Marchetti ◽  
...  
Keyword(s):  
Direct Sequencing ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
Specific Factor ◽  
Mutational Event ◽  
Factor V ◽  
Factor V Leiden Mutation ◽  
Mediterranean Populations ◽  
Factor V Gene ◽  
V Gene

SummaryTwo novel polymorphisms were identified in the factor V gene by direct sequencing of intronic areas. One of them, located in intron 9, is the marker closest to the Leiden mutation ever described, whereas the other, in intron 16, displays a rare allele invariantly associated to the mutation. Allele-specific amplification protocols were designed to perform extensive screenings for both polymorphic sites. The new markers were used in combination with six previously described polymorphisms to define specific factor V gene haplotypes. Haplotype investigations in 506Q homozygous thrombotic patients and normal controls showed the presence of a single haplotype underlying the factor V Leiden mutation in Mediterranean populations (among which Greek Cypriots, where the R506Q mutation is particularly frequent) and Indians. When traced in the absence of the Leiden mutation, the background haplotype was found to be present and roughly as frequent as the mutation itself in these populations. These findings indicate a single mutational event, that probably occurred outside Europe, as the cause of the Leiden mutation and provide a powerful tool to investigate its evolutionary history.

scholarly journals Association analysis of nine missense polymorphisms in the coagulation factor V gene with severe preeclampsia in pregnant Japanese women

2002 ◽  
Vol 47 (3) ◽  
pp. 131-135 ◽  
Author(s):  
H. Watanabe ◽  
H. Hamada ◽  
N. Yamada ◽  
S. Sohda ◽  
K. Yamakawa-Kobayashi ◽  
...  
Keyword(s):  
Association Analysis ◽  
Coagulation Factor ◽  
Japanese Women ◽  
Severe Preeclampsia ◽  
Factor V ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

Polymorphism in exon 10 of the human coagulation factor V gene in a population at risk for sickle cell disease

1997 ◽  
Vol 100 (2) ◽  
pp. 245-248 ◽  
Author(s):  
D. Helley ◽  
Claude Besmond ◽  
Rolande Ducrocq ◽  
F. da Silva ◽  
Marie-Claude Guillin ◽  
...  
Keyword(s):  
At Risk ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Coagulation Factor ◽  
Factor V ◽  
Cell Disease ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene ◽  
Exon 10
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