Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3

2000 ◽  
Vol 106 (6) ◽  
pp. 614-619 ◽  
Author(s):  
Alex V. Postma ◽  
Connie R. Bezzina ◽  
Jeltje F. de Vries ◽  
Arthur A. M. Wilde ◽  
Antoon F. M. Moorman ◽  
...  
Keyword(s):  
Ion Channel ◽  
Chromosomal Localisation ◽  
Genomic Organisation

Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3

2000 ◽  
Vol 106 (6) ◽  
pp. 614-619 ◽  
Author(s):  
Alex V. Postma ◽  
Connie R. Bezzina ◽  
Jeltje F. de Vries ◽  
Arthur A. M. Wilde ◽  
Antoon F. M. Moorman ◽  
...  
Keyword(s):  
Ion Channel ◽  
Chromosomal Localisation ◽  
Genomic Organisation

Genomic organisation and chromosomal localisation of the gene encoding human beta adducin

Gene ◽  
1995 ◽  
Vol 167 (1-2) ◽  
pp. 313-316 ◽  
Author(s):  
Sergio Tisminetzky ◽  
Giulia Devescovi ◽  
Grazia Tripodi ◽  
Andres Muro ◽  
Giuseppe Bianchi ◽  
...  
Keyword(s):  
Gene Encoding ◽  
Chromosomal Localisation ◽  
Genomic Organisation

Myrsinane and related diterpenes from Euphorbia falcata with selective potassium ion channel activity

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
A Vasas ◽  
P Orvos ◽  
L Tálosi ◽  
P Forgo ◽  
G Pinke ◽  
...  
Keyword(s):  
Ion Channel ◽  
Potassium Ion ◽  
Channel Activity ◽  
Potassium Ion Channel

Ion channel alterations and epilepsy in mice and man

2005 ◽  
Vol 36 (02) ◽  
Author(s):  
CM Becker ◽  
J Brill ◽  
K Becker
Keyword(s):  
Ion Channel

Ion Channel Remodelling in Atrial Fibrillation

2011 ◽  
Vol 7 (2) ◽  
pp. 97 ◽  
Author(s):  
Niels Voigt ◽  
Dobromir Dobrev ◽  
◽  
Keyword(s):  
Atrial Fibrillation ◽  
Ion Channel ◽  
Antiarrhythmic Drugs ◽  
Current Knowledge ◽  
Bleeding Complications ◽  
Large Size ◽  
Cardiovascular Morbidity And Mortality ◽  
Number Of Patients ◽  
Life Threatening ◽  
Underlying Mechanisms

Atrial fibrillation (AF) is the most common arrhythmia and is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication. Present drugs used for the therapy of AF (antiarrhythmics and anticoagulants) have major limitations, including incomplete efficacy, risks of life-threatening proarrhythmic events and bleeding complications. Non-pharmacological ablation procedures are efficient and apparently safe, but the very large size of the patient population allows ablation treatment of only a small number of patients. These limitations largely result from limited knowledge about the underlying mechanisms of AF and there is a hope that a better understanding of the molecular basis of AF may lead to the discovery of safer and more effective therapeutic targets. This article reviews the current knowledge about AF-related ion-channel remodelling and discusses how these alterations might affect the efficacy of antiarrhythmic drugs.

Upscaling and Automation of Electrophysiology: Toward High Throughput Screening in Ion Channel Drug Discovery

2003 ◽  
Vol 9 (1) ◽  
pp. 49-58
Author(s):  
Margit Asmild ◽  
Nicholas Oswald ◽  
Karen M. Krzywkowski ◽  
Søren Friis ◽  
Rasmus B. Jacobsen ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Ion Channel ◽  
High Throughput ◽  
High Throughput Screening
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