Analysis of the major domains of the F fertility inhibition protein, FinO

1998 ◽  
Vol 259 (6) ◽  
pp. 622-629 ◽  
Author(s):  
J. R. Sandercock ◽  
L. S. Frost
Keyword(s):  
Fertility Inhibition

Steroid release from polymer vaginal devices. Effect on fertility inhibition

Steroids ◽  
1973 ◽  
Vol 21 (3) ◽  
pp. 325-333 ◽  
Author(s):  
Juan Zañartu ◽  
Rodolfo Guerrero
Keyword(s):  
Fertility Inhibition

Follicle-stimulating hormone receptor (FSHR)-derived peptide vaccine induced infertility in mice without pathological effect on reproductive organs

2011 ◽  
Vol 23 (4) ◽  
pp. 544 ◽  
Author(s):  
Li-Hua Yang ◽  
Jin-Tao Li ◽  
Ping Yan ◽  
Hong-Li Liu ◽  
Su-Yun Zeng ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Follicle Stimulating Hormone ◽  
Peptide Vaccine ◽  
Reproductive Organs ◽  
Seminiferous Tubules ◽  
Pathological Effect ◽  
Contraceptive Vaccine ◽  
Fertility Inhibition ◽  
Cellular Swelling ◽  
Stimulating Hormone

In a previous study it was found that priming with recombinant human follicle-stimulating hormone receptor (rhFSHR) protein (F140) and boosting with a peptide containing amino acids 32–44 from FSHR showed a specific immune response and fertility inhibition in adult male mice. However, this priming and boosting led to damage of the reproductive organs. Therefore, to eliminate this damage, the peptide prime–boost strategy was explored as a possible means of avoiding the pathological change while maintaining infertility. Immunisation with the peptide prime–boost strategy led to decreased fertility 10 weeks after vaccination, which is consistent with Balb/C mice treated with the protein prime–peptide boost regime. In contrast to the cellular swelling and spotty necrosis in spermatogonia observed in the protein-primed mice, the mice receiving peptide priming did not display pathological damage in seminiferous tubules and interstitial cells. Thus, the prime–boost immune regime with the FSHR-derived peptide potentially provides a much safer candidate for a contraceptive vaccine.

scholarly journals Fertility inhibition of RP1 by IncN plasmid pKM101.

1985 ◽  
Vol 161 (1) ◽  
pp. 425-427 ◽  
Author(s):  
S C Winans ◽  
G C Walker
Keyword(s):  
Fertility Inhibition ◽  
Plasmid Pkm101

scholarly journals Genome organization of thePseudomonas aeruginosanarrow host range plasmid R91–5 determined by deletion and cloning analysis

1985 ◽  
Vol 45 (2) ◽  
pp. 195-198 ◽  
Author(s):  
R. J. Moore ◽  
V. Krishnapillai
Keyword(s):  
Genetic Analysis ◽  
Host Range ◽  
Restriction Enzyme ◽  
Genome Organization ◽  
Conjugative Plasmid ◽  
Deletion Mutants ◽  
Broad Host Range ◽  
Dna Fragments ◽  
Narrow Host Range ◽  
Fertility Inhibition

SummaryBy physical and genetic analysis of deletion mutants of the narrow host range IncP-10P. aeruginosaconjugative plasmid R91–5 it has been shown that the phenotypes related to its transfer, namely the inhibition of the replication of the phage G101, entry exclusion and the fertility inhibition of the wide host range plasmid R18 map at kilobase coordinates 19·7–20·7, 18·5–19·7, 28·8–30·15 and/or 34·9–36·15, respectively. These locations have been confirmed by cloning restriction enzyme generated DNA fragments of R91–5 into a small broad host range, multicopy non-conjugative plasmid.

scholarly journals Change of drug resistance patterns and genetic properties of R plasmids inSalmonella typhimuriumof bovine origin isolated from 1970 to 1979 in northern Japan

1981 ◽  
Vol 87 (2) ◽  
pp. 257-269 ◽  
Author(s):  
S. Makino ◽  
N. Ishiguro ◽  
G. Sato ◽  
N. Seno
Keyword(s):  
Drug Resistance ◽  
Mercury Resistance ◽  
Drug Resistant ◽  
Fertility Inhibition ◽  
Resistance Patterns ◽  
Clonal Distribution ◽  
R Plasmids ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Northern Japan

SummaryA total of 321Salmonella typhimuriumstrains of bovine origin obtained in northern Japan during the period 1970–1979 were tested for drug resistance and detection of conjugative R plasmids. Three hundred and eighteen (99·1 %) of these strains were resistant to one or more drugs. The isolation frequency of multiply drug-resistant strains tended to increase year by year. Two hundred and thirty-seven (74·5%) of these resistant strains carried conjugative R plasmids. A total of 308 R plasmids including 174 (56·5 %) thermosensitive (ts) R plasmids were derived from the 237 drug-resistant strains, indicating that 71 (30·0%) strains have two different conjugative R plasmids in a single host cell. Of the 308 R plasmids examined for fertility inhibition (fi), 167 ts and 131 non-ts R plasmids werefi−. Of the 60 ts R plasmids examined for incompatibility, 50 were classified into H1 group and 10 into H2 group. Of the 52 non-ts R plasmids examined, 35 were classified into the Iα group and the remaining plasmids were untypable in our tests. Mercury resistance marker was found in about 20% of H1 R plasmids coding for multiresistance, and all of H2 R plasmids coded for resistance to tellurite. The clonal distribution of anS. typhimuriumstrain which carried an H1 R plasmid coding for resistance to six drugs and mercury was recognized in 1978 and 1979.

Insect Fertility: Inhibition by Folic Acid Derivatives

Science ◽  
1964 ◽  
Vol 144 (3616) ◽  
pp. 308-309 ◽  
Author(s):  
M. M. Crystal
Keyword(s):  
Folic Acid ◽  
Fertility Inhibition

Fertility inhibition by intraoviductal copper beads in rabbits

Contraception ◽  
1978 ◽  
Vol 17 (6) ◽  
pp. 553-562 ◽  
Author(s):  
Silvia Quijada ◽  
Ximena Soza ◽  
Horacio B. Croxatto
Keyword(s):  
Fertility Inhibition
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