Regulation of bacteriocin production in Lactobacillus plantarum depends on a conserved promoter arrangement with consensus binding sequence

2001 ◽  
Vol 265 (1) ◽  
pp. 198-206 ◽  
Author(s):  
P. A. Risøen ◽  
O. Johnsborg ◽  
D. B. Diep ◽  
L. Hamoen ◽  
G. Venema ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Bacteriocin Production ◽  
Consensus Binding Sequence ◽  
Binding Sequence

scholarly journals Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Yanli Bi ◽  
Longyuan Gong ◽  
Pengyuan Liu ◽  
Xiufang Xiong ◽  
Yongchao Zhao
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Transcriptional Repression ◽  
Breast Cancer Cells ◽  
Kinase Activity ◽  
Nuclear Translocation ◽  
Extracellular Signals ◽  
Consensus Binding Sequence ◽  
Binding Sequence

AbstractErbB2, a classical receptor tyrosine kinase, is frequently overexpressed in breast cancer cells. Although the role of ErbB2 in the transmission of extracellular signals to intracellular matrix has been widely studied, the functions of nuclear ErbB2 remain largely elusive. Here, we report a novel function of nuclear ErbB2 in repressing the transcription of DEPTOR, a direct inhibitor of mTOR. Nuclear ErbB2 directly binds to the consensus binding sequence in the DEPTOR promoter to repress its transcription. The kinase activity of ErbB2 is required for its nuclear translocation and transcriptional repression of DEPTOR. Moreover, the repressed DEPTOR by nuclear ErbB2 inhibits the induction of autophagy by activating mTORC1. Thus, our study reveals a novel mechanism for autophagy regulation by functional ErbB2, which translocates to the nucleus and acts as a transcriptional regulator to suppress DEPTOR transcription, leading to activation of the PI3K/AKT/mTOR pathway to inhibit autophagy.

scholarly journals Enhanced Bacteriocin Production by Pediococcus pentosaceus 147 in Co-culture With Lactobacillus plantarum LE27 on Cheese Whey Broth

2018 ◽  
Vol 9 ◽  
Author(s):  
Carolina Gutiérrez-Cortés ◽  
Héctor Suarez ◽  
Gustavo Buitrago ◽  
Luis Augusto Nero ◽  
Svetoslav Dimitrov Todorov
Keyword(s):  
Lactobacillus Plantarum ◽  
Cheese Whey ◽  
Bacteriocin Production ◽  
Pediococcus Pentosaceus

scholarly journals Bacteriocin production by Lactobacillus plantarum ST16Pa in supplemented whey powder formulations

2019 ◽  
Vol 102 (1) ◽  
pp. 87-99 ◽  
Author(s):  
Sabrina S. Sabo ◽  
Attilio Converti ◽  
Simone Ichiwaki ◽  
Ricardo P.S. Oliveira
Keyword(s):  
Lactobacillus Plantarum ◽  
Bacteriocin Production ◽  
Whey Powder

scholarly journals Definition of the transcription factor TdIF1 consensus-binding sequence through genomewide mapping of its binding sites

2015 ◽  
Vol 20 (3) ◽  
pp. 242-254 ◽  
Author(s):  
Kotaro Koiwai ◽  
Takashi Kubota ◽  
Nobuhisa Watanabe ◽  
Katsutoshi Hori ◽  
Osamu Koiwai ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Binding Sites ◽  
Consensus Binding Sequence ◽  
Definition Of ◽  
Binding Sequence

scholarly journals Evidence for dual functionality of the operon plnABCD in the regulation of bacteriocin production in Lactobacillus plantarum

2001 ◽  
Vol 41 (3) ◽  
pp. 633-644 ◽  
Author(s):  
Dzung B. Diep ◽  
Ola Johnsborg ◽  
Per Arne Risøen ◽  
Ingolf F. Nes
Keyword(s):  
Lactobacillus Plantarum ◽  
Bacteriocin Production

The human placenta expresses transcription enhancer factor-1 but there is no correlation with the expression of placental lactogen

1996 ◽  
Vol 16 (2) ◽  
pp. 205-210 ◽  
Author(s):  
G Quinn ◽  
D S W Boam ◽  
J R E Davis ◽  
J D Glazier ◽  
P Mylona ◽  
...  
Keyword(s):  
Human Placenta ◽  
First Trimester ◽  
Placental Lactogen ◽  
Transcriptional Enhancer ◽  
Term Placenta ◽  
Consensus Binding Sequence ◽  
Cytotrophoblast Cells ◽  
Binding Sequence ◽  
Transcription Enhancer ◽  
Enhancer Factor

ABSTRACT A transcriptional enhancer which has a consensus binding sequence for transcription enhancer factor-1 (TEF-1) has been found 3′ of the hPL3 gene. We examined whether TEF-1 is expressed by the human placenta and whether such expression is co-ordinated with that of human placental lactogen (hPL). Probing Northern blots of total RNA from first trimester and term placenta, the choriocarcinoma-derived cell line JAr and primary cultured cytotrophoblast cells with a cDNA for TEF-1 revealed transcripts of 12–13 kb and 3–4 kb. The level of TEF-1 expression was the same in first trimester as compared with term placenta and in undifferentiated JAr as compared with differentiated cytotrophoblast cells. hPL expression was tenfold higher in term compared with first trimester placenta and, whilst detectable in cytotrophoblast cells, was undetectable in JAr cells. These data show that TEF-1 is expressed by the placenta but is not co-ordinated with hPL expression.

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