Entamoeba histolytica  : production of nitric oxide and in situ activity of NADPH diaphorase in amebic liver abscess of hamsters

2001 ◽  
Vol 87 (1) ◽  
pp. 49-56 ◽  
Author(s):  
J. Pacheco-Yépez ◽  
R. Campos-Rodríguez ◽  
M. Shibayama ◽  
J. Ventura-Juárez ◽  
J. Serrano-Luna ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Entamoeba Histolytica ◽  
Liver Abscess ◽  
Nadph Diaphorase ◽  
Amebic Liver Abscess

Cutaneous Amebiasis

PEDIATRICS ◽  
1983 ◽  
Vol 71 (4) ◽  
pp. 595-598
Author(s):  
Mary Ellen Rimsza ◽  
Robert A. Berg
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Wall ◽  
Entamoeba Histolytica ◽  
Liver Abscess ◽  
Rare Complication ◽  
Hepatic Abscess ◽  
Amebic Liver Abscess ◽  
Colostomy Site ◽  
Histolytica Infection ◽  
Laparotomy Incision

An infant with cutaneous amebiasis of the vulva and amebic liver abscess is described. Epidemiologic investigations and serologic studies were crucial in establishing the diagnosis. The vulvar amebic ulcers responded dramatically to metronidazole therapy. Cutaneous amebiasis is a rare complication of Entamoeba histolytica infection which should be considered in the differential diagnosis of perineovulvar or penile ulcers. Cutaneous amebiasis may also occur on the abdominal wall surrounding a draining hepatic abscess, colostomy site, or laparotomy incision.

scholarly journals Pulmonary Thromboembolism Complicating Amebic Liver Abscess: First Reported Case in the United States—Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Devon McKenzie ◽  
Michael Gale ◽  
Sunny Patel ◽  
Grazyna Kaluta
Keyword(s):  
Inferior Vena Cava ◽  
Entamoeba Histolytica ◽  
Liver Abscess ◽  
Inferior Vena ◽  
Pulmonary Thromboembolism ◽  
Current Knowledge ◽  
Vena Cava ◽  
The United States ◽  
Amebic Liver Abscess ◽  
The Usa

Even in the absence of Amebic colitis, Amebic liver abscess (ALA) is the most common extraintestinal complication ofEntamoeba histolyticainfection. In the USA, it is most prevalent in middle aged immigrant males from endemic countries such as Africa, Mexico, and India. One of the complications of ALA is inferior vena cava (IVC) thrombosis, which is believed to result from the mechanical compression of the IVC and the consequent thrombogenic nidus elicited from the resultant inflammatory response. There are very few reported cases and even fewer in which the thrombus became a harbinger to pulmonary thromboembolism. We present the case of a 43-year-old male from West Africa who presented with the chief complaint of right upper quadrant abdominal pain for one week associated with persistent nonproductive cough. He had a positive serumEntamoeba histolyticaantibody with CT scan findings of a hepatic abscess with thrombosis of the hepatic vein and inferior vena cava and numerous bilateral pulmonary emboli. This amebic liver abscess was successfully treated with metronidazole and paromomycin, whereas the pulmonary thromboembolism was managed with medical anticoagulation. Based on current knowledge, this is the first reported case in the USA.

scholarly journals Expression of Amoebapores Is Required for Full Expression of Entamoeba histolytica Virulence in Amebic Liver Abscess but Is Not Necessary for the Induction of Inflammation or Tissue Damage in Amebic Colitis

2004 ◽  
Vol 72 (2) ◽  
pp. 678-683 ◽  
Author(s):  
Xiaochun Zhang ◽  
Zhi Zhang ◽  
Diane Alexander ◽  
Rivka Bracha ◽  
David Mirelman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Entamoeba Histolytica ◽  
Liver Abscess ◽  
Tissue Damage ◽  
Scid Mouse ◽  
Amebic Liver Abscess ◽  
Amphipathic Peptides ◽  
Amebic Colitis ◽  
Scid Mouse Model ◽  
Cellular Lysis

ABSTRACT Entamoeba histolytica trophozoites produce amoebapores, a family of small amphipathic peptides capable of insertion into bacterial or eukaryotic membranes and causing cellular lysis. Recently, E. histolytica trophozoites that are totally deficient in the production of amoebapore-A were created through a gene silencing mechanism (R. Bracha, Y. Nuchamowitz, and D. Mirelman, Eukaryot. Cell 2:295-305, 2003). Here we tested the virulence of amoebapore A(−) trophozoites in models of the two major forms of amebic disease: amebic liver abscess and amebic colitis. We demonstrate that amoebapore expression is required for full virulence in the SCID mouse model of amebic liver abscess, but E. histolytica trophozoites that do not express amoebapore-A can still cause inflammation and tissue damage in infected human colonic xenografts. These data are consistent with the concept that tissue damage may proceed by different mechanisms in amebic liver abscess compared to amebic colitis.

scholarly journals Diagnosis of Amebic Liver Abscess and Intestinal Infection with the TechLab Entamoeba histolytica II Antigen Detection and Antibody Tests

2000 ◽  
Vol 38 (9) ◽  
pp. 3235-3239 ◽  
Author(s):  
Rashidul Haque ◽  
Nasir Uddin Mollah ◽  
Ibne Karim M. Ali ◽  
Khorshed Alam ◽  
Aleida Eubanks ◽  
...  
Keyword(s):  
Entamoeba Histolytica ◽  
Liver Abscess ◽  
Positive Culture ◽  
Antigen Detection ◽  
Pcr Analysis ◽  
Amebic Liver Abscess ◽  
Intestinal Infection ◽  
Entamoeba Dispar ◽  
Stool Specimens ◽  
Culture Negative

A noninvasive diagnostic test for amebic liver abscess is needed, because amebic and bacterial abscesses appear identical on ultrasound or computer tomography and because it is rarely possible to identifyEntamoeba histolytica in stool specimens from patients with amebic liver abscess. Here we report a method of detection in serum of circulating E. histolytica Gal/GalNAc lectin to diagnose amebic liver abscess, which was used in patients from Dhaka, Bangladesh. The TechLab E. histolytica II test (which differentiates the true pathogen E. histolytica fromEntamoeba dispar) detected Gal/GalNAc lectin in the sera of 22 of 23 (96%) amebic liver abscess patients tested prior to treatment with the antiamebic drug metronidazole and 0 of 70 (0%) controls. After 1 week of treatment with metronidazole, 9 of 11 (82%) patients became serum lectin antigen negative. The sensitivity of the E. histolytica II antigen detection test for intestinal infection was also evaluated. Antigen detection identified E. histolytica infection in 50 samples from 1,164 asymptomatic preschool children aged 2 to 5 years, including 16 of 16 (100%) culture-positive specimens. PCR analysis of stool specimens was used to confirm that most antigen-positive but culture-negative specimens were true-positive: PCR identified parasite DNA in 27 of 34 (79%) of the antigen-positive, culture-negative stool specimens. Antigen detection was a more sensitive test for infection than antilectin antibodies, which were detected in only 76 of 98 (78%) amebic liver abscess patients and in 26 of 50 (52%) patients with intestinal infection. We conclude that the TechLab E. histolytica II kit is a sensitive means to diagnose hepatic and intestinal amebiasis prior to the institution of metronidazole treatment.

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