The role of serum and gastric juice levels of carcinoembryonic antigen, CA19.9 and CA72.4 in patients with gastric cancer

1998 ◽  
Vol 124 (8) ◽  
pp. 450-455 ◽  
Author(s):  
Adriano Tocchi ◽  
Gianluca Costa ◽  
Luca Lepre ◽  
Gianluca Liotta ◽  
Gianluca Mazzoni ◽  
...  
2018 ◽  
Vol 01 (1) ◽  
Author(s):  
Takalkar U Vidyadhar

Gastric cancer is a multifactorial disease with complex interplay of environmental and genetic factors. Helicobacter pylori (H. pylori) infestation has been identified as the most important etiological agent in the pathogenesis of gastric cancer. Also, the role of dietary factors that is low consumption of fruits and vegetables have been found to be associated with gastric cancer. Among the dietary factors, antioxidants especially vitamin C has been found to confer the strongest protection against gastric cancer. Its anti-proliferative and pro-apoptotic action has been suggested in vitro. Because of its antioxidant activity, it protects cells against oxidative DNA damage caused by toxic effects of reactive oxygen species. It also inhibits production of carcinogenic N-nitroso compound in the stomach. The person with H. pylori infection has low levels of vitamin C in their gastric juice and levels of vitamin C normalizes on eradication of H. pylori. Vitamin C levels are high in gastric mucosa and gastric juice, sometimes more than that of in plasma. But gastric pathological conditions cause lowered secretion of vitamin C into gastric juice. Effect of H. pylori on vitamin C in gastric juice is reversible and on eradication of H. pylori, it returns to normal level. Hence, eradication of H. pylori and chemoprevention with antioxidant supplementation will be an effective preventive strategy to reduce the incidence of gastric cancer and related mortality. Vitamin C and gastric cancer is an area of potential interest for researchers as a preventive measure. Keywords: Vitamin C, H. pylori, gastric cancer.


Oncology ◽  
1988 ◽  
Vol 45 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Masaharu Tatsuta ◽  
Hiroyasu Iishi ◽  
Hisako Yamamura ◽  
Shigeru Okudo

2018 ◽  
Author(s):  
Takalkar U Vidyadhar

Gastric cancer is a multifactorial disease with complex interplay of environmental and genetic factors. Helicobacter pylori (H. pylori) infestation has been identified as the most important etiological agent in the pathogenesis of gastric cancer. Also, the role of dietary factors that is low consumption of fruits and vegetables have been found to be associated with gastric cancer. Among the dietary factors, antioxidants especially vitamin C has been found to confer the strongest protection against gastric cancer. Its anti-proliferative and pro-apoptotic action has been suggested in vitro. Because of its antioxidant activity, it protects cells against oxidative DNA damage caused by toxic effects of reactive oxygen species. It also inhibits production of carcinogenic N-nitroso compound in the stomach. The person with H. pylori infection has low levels of vitamin C in their gastric juice and levels of vitamin C normalizes on eradication of H. pylori. Vitamin C levels are high in gastric mucosa and gastric juice, sometimes more than that of in plasma. But gastric pathological conditions cause lowered secretion of vitamin C into gastric juice. Effect of H. pylori on vitamin C in gastric juice is reversible and on eradication of H. pylori, it returns to normal level. Hence, eradication of H. pylori and chemoprevention with antioxidant supplementation will be an effective preventive strategy to reduce the incidence of gastric cancer and related mortality. Vitamin C and gastric cancer is an area of potential interest for researchers as a preventive measure. Keywords: Vitamin C, H. pylori, gastric cancer.


1983 ◽  
Vol 13 (4) ◽  
pp. 324-330 ◽  
Author(s):  
Osamu Kojima ◽  
Takuro Tanioku ◽  
Naoki Kitagawa ◽  
Akimune Oh ◽  
Yasuo Uehara ◽  
...  

Cancer ◽  
1980 ◽  
Vol 46 (12) ◽  
pp. 2686-2692 ◽  
Author(s):  
Masaharu Tatsuta ◽  
Tadao Itoh ◽  
Shigeru Okuda ◽  
Hisako Yamamura ◽  
Miyako Baba ◽  
...  

Oncology ◽  
1986 ◽  
Vol 43 (3) ◽  
pp. 149-153 ◽  
Author(s):  
Mauro Castelli ◽  
Stefano Guadagni ◽  
Anna Bagnato ◽  
Maria Antonietta Pistoia ◽  
Manlio Carboni ◽  
...  

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