Soluble vascular cell-adhesion molecule-1 and soluble intercellular adhesion molecule-1 correlate with lipid and apolipoprotein risk factors for coronary artery disease in children

1999 ◽  
Vol 158 (7) ◽  
pp. 592-598 ◽  
Author(s):  
T. Ohta ◽  
K. Saku ◽  
K. Takata ◽  
N. Adachi
Keyword(s):  
Risk Factors ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Intercellular Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Intercellular Adhesion Molecule 1 ◽  
Vascular Cell ◽  
Soluble Intercellular Adhesion Molecule ◽  
Artery Disease ◽  
Cell Adhesion Molecule 1

Serum Levels of Soluble Intercellular Adhesion Molecule-1 and Soluble Vascular Cell Adhesion Molecule-1 in Liver Disease, and Their Changes by Treatment with Interferon

1996 ◽  
Vol 24 (3) ◽  
pp. 258-265 ◽  
Author(s):  
A Marui ◽  
Y Fukuda ◽  
Y Koyama ◽  
I Nakano ◽  
F Urano ◽  
...  
Keyword(s):  
Liver Disease ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Serum Levels ◽  
Intercellular Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Intercellular Adhesion Molecule 1 ◽  
Vascular Cell ◽  
Soluble Intercellular Adhesion Molecule ◽  
Cell Adhesion Molecule 1

Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured by an enzyme-linked immunosorbent assay in patients with chronic hepatitis ( n = 57), liver cirrhosis ( n = 19) and hepatocellular carcinoma (n = 33). Serum levéis of sICAM-1 and sVCAM-1 were significantly higher in liver disease than those in controls ( P < 0.0001 and P < 0.0005, respectively). A total of 22 patients with chronic hepatitis C were treated with interferon. Pretreatment levels of sICAM-1 and sVCAM-1 were not significantly different between complete responders and non-responders. In complete responders, serum sICAM-1 and sVCAM-1 levels 1 year after interferon treatment significantly decreased compared to the pretreatment levels ( P < 0.005 and P < 0.05, respectively). Post-treatment levels of sICAM-1 and sVCAM-1 in complete responders were also significantly lower than those in non-responders ( P < 0.005 and P < 0.05, respectively). This suggests that monitoring soluble adhesion molecules might be useful in the follow-up of patients with liver disease.

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