Thiamine-responsive lactic acidaemia: role of pyruvate dehydrogenase complex

1998 ◽  
Vol 157 (8) ◽  
pp. 648-652 ◽  
Author(s):  
E. Naito ◽  
M. Ito ◽  
I. Yokota ◽  
T. Saijo ◽  
J. Matsuda ◽  
...  
Keyword(s):  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Lactic Acidaemia ◽  
Dehydrogenase Complex

scholarly journals Emerging regulatory roles of mitochondrial sirtuins on pyruvate dehydrogenase complex and the related metabolic diseases: Review

2020 ◽  
Vol 7 (2) ◽  
pp. 3645-3658
Author(s):  
Abolfazl Nasiri ◽  
Masoud Sadeghi ◽  
Asad Vaisi-Raygani ◽  
Sara Kiani ◽  
Zahra Aghelan ◽  
...  
Keyword(s):  
Posttranslational Modifications ◽  
Pyruvate Dehydrogenase ◽  
Structural Changes ◽  
Metabolic Diseases ◽  
Pyruvate Dehydrogenase Complex ◽  
Mitochondrial Protein ◽  
Krebs Cycle ◽  
Acetyl Coa ◽  
Dehydrogenase Complex

The pyruvate dehydrogenase complex (PDC) is a multi-enzyme complex of the mitochondria that provides a link between glycolysis and the Krebs cycle. PDC plays an essential role in producing acetyl-CoA from glucose and the regulation of fuel consumption. In general, PDC enzyme is regulated in two different ways, end-product inhibition and posttranslational modifications (more extensive phosphorylation and dephosphorylation subunit E1). Posttranslational modifications of this enzyme are regulated by various factors. Sirtuins are the class III of histone deacylatases that catalyze protein posttranslational modifications, including deacetylation, adenosine diphosphate ribosylation, and deacylation. Sirt3, Sirt4, and Sirt5 are mitochondrial sirtuins that control the posttranslational modifications of mitochondrial protein. Considering the comprehensive role of sirtuins in post-translational modifications and regulation of metabolic processes, the aim of this review is to explore the role of mitochondrial sirtuins in the regulation of the PDC. PDC deficiency is a common metabolic disorder that causes pyruvate to be converted to lactate and alanine rather than to acetyl-CoA. because this enzyme is in the gateway of complete oxidation, glucose products entering the Krebs cycle and resulting in physiological and structural changes in the organs. Metabolic blockage such as ketogenic diet broken up by b -oxidation and producing acetyl-CoA can improve the patients. Sirtuins play a role in the production of acetyl-CoA through oxidation of fatty acids and other pathways. Thus, we hypothesize that the targets and bioactive compounds targeting mitochondrial sirtuins can be involved in the treatment of PDC deficiency. In general, this review discusses the present knowledge on how mitochondrial sirtuins are involved in the regulation of PDC as well as their possible roles in the treatment of PDC deficiency.

The role of Pyruvate Dehydrogenase Complex in cardiovascular diseases

Life Sciences ◽  
2015 ◽  
Vol 121 ◽  
pp. 97-103 ◽  
Author(s):  
Wanqing Sun ◽  
Quan Liu ◽  
Jiyan Leng ◽  
Yang Zheng ◽  
Ji Li
Keyword(s):  
Cardiovascular Diseases ◽  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Dehydrogenase Complex

Role of protein X in the function of the mammalian pyruvate dehydrogenase complex

1989 ◽  
Vol 160 (2) ◽  
pp. 715-721 ◽  
Author(s):  
Subramanian Gopalakrishnan ◽  
Mohammed Rahmatullah ◽  
Gary A. Radke ◽  
Susan Powers-Greenwood ◽  
Thomas E. Roche
Keyword(s):  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Protein X ◽  
Dehydrogenase Complex
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