Faecal immunoreactive lipase: a simple diagnostic test for cystic fibrosis

1998 ◽  
Vol 157 (4) ◽  
pp. 282-286 ◽  
Author(s):  
R. Münch ◽  
C. P. Brägger ◽  
J. Altorfer ◽  
B. Hoppe ◽  
D. H. Shmerling ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Diagnostic Test ◽  
Lipase A

scholarly journals WS10.2 Organoids as diagnostic test for cystic fibrosis

2017 ◽  
Vol 16 ◽  
pp. S18
Author(s):  
A.S. Ramalho ◽  
P. Peetermans ◽  
M. Nobens ◽  
M. Ferrant ◽  
M. Proesmans ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Diagnostic Test

Evaluation of the intestinal current measurement method as a diagnostic test for cystic fibrosis

2012 ◽  
Vol 48 (3) ◽  
pp. 229-235 ◽  
Author(s):  
Malena Cohen-Cymberknoh ◽  
Yasmin Yaakov ◽  
David Shoseyov ◽  
Eyal Shteyer ◽  
Edna Schachar ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Diagnostic Test ◽  
Measurement Method ◽  
Current Measurement

Employing the nasal potential difference as a diagnostic test for cystic fibrosis in neonates: Potential pitfalls

2002 ◽  
Vol 141 (2) ◽  
pp. 0295-0296 ◽  
Author(s):  
Erol A. Gaillard ◽  
Nigel J. Shaw ◽  
Nim V. Subhedar ◽  
Helen L. Wallace ◽  
Kevin W. Southern
Keyword(s):  
Cystic Fibrosis ◽  
Diagnostic Test ◽  
Potential Difference ◽  
Nasal Potential Difference

scholarly journals Non-invasive Diagnostic Tests in Cystic Fibrosis-Related Liver Disease: A Diagnostic Test Accuracy Network Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Ágnes Rita Martonosi ◽  
Alexandra Soós ◽  
Zoltán Rumbus ◽  
Péter Hegyi ◽  
Vera Izsák ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Diagnostic Test ◽  
Diagnostic Performance ◽  
Transient Elastography ◽  
Meta Analysis ◽  
Test Accuracy ◽  
Non Invasive ◽  
Related Liver Disease ◽  
New Criteria

Background and Aims: Cystic fibrosis-related liver disease (CFLD) is one of the leading causes of morbidity and mortality in cystic fibrosis (CF). Several non-invasive diagnostic methods have been proposed as screening tools for CFLD. Our aim was to rank all available non-invasive modalities for diagnostic performance.Methods: A systematic search was performed in five medical databases to find studies which reported on any single or composite non-invasive diagnostic test (as an index test) compared to the Debray, the EuroCare or the Colombo criteria (as a reference standard). Ranking was carried out with a Bayesian diagnostic test accuracy network meta-analysis based on superiority indices, calculated for pooled sensitivity (Se) and specificity (Sp) with a 95% confidence interval (CI). The study was registered under CRD42020155846 in PROSPERO.Results: Fifteen studies with 15 index tests and a combination of them were included. The New criteria proposed by Koh et al. – which represent a composite diagnostic definition for CFLD including liver biochemistry, ultrasonography, transient elastography and fibrosis markers—had the best performance for detecting CFLD (Se:94%[CI:58–100], Sp:72%[CI:52–84]); while transient elastography (Se:65%[CI:56–74], Sp:88%[CI:84–91]) and a combination of it with a tissue inhibitor of metalloproteinase-4 measurement (Se:78%[CI:30–100], Sp:64%[CI:18–95%]) proved to be the second and third best options, respectively. In the imaging techniques subgroup, transient elastography (Se:66%[CI:57–72], Sp:88%[CI:85–91%]), acoustic radiation force impulse in the right lobe (Se:54%[CI:33–74], Sp:88%[CI:66–96]) and that in the left lobe (Se:55%[CI:23–81], Sp:82%[CI:50–95]) were ranked the highest. Comparing biochemical markers/fibrosis indices, the measurement of the Forns index (Se:72%[CI:25–99], Sp:63%[CI:16–94]), the aspartate aminotransferase-to-platelet ratio (Se:55%[CI:41–68], Sp:83%[CI:66–89]) and alkaline phosphatase (Se:63%[CI:18–93], Sp:64%[CI:19–95]) were ranked the highest.Conclusion: The New criteria show the best diagnostic performance. In clinical practice, transient elastography seems to be a simple, cheap and non-invasive tool, outperforming imaging, biochemical and fibrosis tests for detecting CFLD. Further studies are needed to validate our findings.

THE SWEAT TEST

PEDIATRICS ◽  
1962 ◽  
Vol 30 (2) ◽  
pp. 167-171
Author(s):  
HARRY SHWACHMAN
Keyword(s):  
Cystic Fibrosis ◽  
Diagnostic Test ◽  
Marked Reduction ◽  
Exocrine Pancreatic Function ◽  
Sweat Test ◽  
Special Study ◽  
Duodenal Fluid ◽  
Difficult Time ◽  
Normal Enzyme

AN INCREASED interest in the physiology of sweating was precipitated by the demonstration of markedly elevated electrolyte levels in sweat of patients with cystic fibrosis. Indeed, the determination of sweat electrolytes has become the most reliable single diagnostic test for cystic fibrosis, replacing the more difficult, time consuming, uncomfortable, and less reliable procedures of duodenal fluid aspiration and assay. The marked reduction or absence of proteolytic activity of duodenal fluid no longer serves as the cornerstone of diagnosis, since fully 15% of patients with cystic fibrosis have sufficient exocrine pancreatic function to yield normal or nearly normal enzyme values. Nevertheless, study of duodenal fluid is still of considerable value when dealing with cases difficult to diagnose, in instances of borderline sweat electrolyte levels, or for special study purposes.

An Unusual Case of Munchausen Syndrome by Proxy

1991 ◽  
Vol 25 (3) ◽  
pp. 422-425 ◽  
Author(s):  
Toni Single ◽  
Richard Leigh Henry
Keyword(s):  
Cystic Fibrosis ◽  
Medical History ◽  
Diagnostic Test ◽  
Unusual Case ◽  
Medical Personnel ◽  
Sweat Test ◽  
Munchausen Syndrome ◽  
Munchausen Syndrome By Proxy ◽  
History Of

An 11-year-old boy was presented by his father with a long and plausible history of cystic fibrosis. The diagnostic test for cystic fibrosis, the sweat test, was normal and excluded the diagnosis. The medical history was later found to be false, and the child to be well. By definition, the case met the criteria for Munchausen Syndrome by Proxy with fabrication of symptoms on behalf of another in order to deceive medical personnel. Unusual features included the illness chosen, the father as the parent falsifying illness, his failure to pursue unnecessary investigations and treatment, and the ease with which he relinquished the diagnosis of cystic fibrosis.

Stool elastase as a diagnostic test for pancreatic function in children with cystic fibrosis

The Lancet ◽  
1997 ◽  
Vol 350 (9083) ◽  
pp. 1001 ◽  
Author(s):  
Colin Wallis ◽  
Theresa Leung ◽  
David Cubitt ◽  
Anthony Reynolds
Keyword(s):  
Cystic Fibrosis ◽  
Diagnostic Test ◽  
Pancreatic Function
Sign in / Sign up

Export Citation Format

Share Document