Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: combined near infrared spectropho- tometry and Doppler ultrasound study

1994 ◽  
Vol 153 (7) ◽  
pp. 504-509
Author(s):  
K. D. Liem ◽  
J. C. W. Hopman ◽  
L. A. A. Koll�e ◽  
B. Oeseburg
Keyword(s):  
Preterm Infants ◽  
Doppler Ultrasound ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Ultrasound Study

The Effect of Antenatal Neuroprotective Magnesium Sulfate Treatment on Cerebral Oxygenation in Preterm Infants

2020 ◽  
Author(s):  
Buse Ozer Bekmez ◽  
Yüksel Oğuz ◽  
Hayriye Gözde Kanmaz Kutman ◽  
Dilek Uygur ◽  
Fuat Emre Canpolat ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Preterm Infants ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Postnatal Life ◽  
Regional Cerebral Oxygen Saturation ◽  
Future Studies ◽  
The Third ◽  
Early Postnatal Life ◽  
Underlying Mechanisms

Abstract Objective Antenatal magnesium sulfate (MgSO4) treatment is associated with reduced risk of cerebral palsy in preterm infants. We aimed to investigate whether this treatment leads to any alterations on cerebral hemodynamics which could be detected by near-infrared spectroscopy (NIRS) readings in early postnatal life. Study design Infants with gestational ages (GAs) ≤ 32 weeks were divided into two groups regarding their exposure to antenatal neuroprotective MgSO4 treatment or not. NIRS monitoring was performed to all infants, and readings were recorded for 2 hours each day during the first 3 days of life. The primary aim was to compare regional cerebral oxygen saturation (rcSO2) and cerebral fractional tissue oxygen extraction (cFTOE) between the groups. Results Sixty-six infants were exposed to antenatal MgSO4, while 64 of them did not. GA and birth weight were significantly lower in the treatment group (p < 0.01). No difference was observed in rcSO2 and cFTOE levels in the first, second, and the third days of life (p > 0.05). An insignificant reduction in severe intraventricular hemorrhage rates was observed (8 vs. 15%, p = 0.24). Conclusion We could not demonstrate any effect on cerebral oxygenation of preterm infants in early postnatal life that could be attributed to antenatal neuroprotective MgSO4 treatment. Future studies are warranted to clarify the exact underlying mechanisms of neuroprotection.

Effects of Single Loading Dose of Intravenous Caffeine on Cerebral Oxygenation in Preterm Infants

2020 ◽  
Author(s):  
Ozkan Ilhan ◽  
Meltem Bor
Keyword(s):  
Preterm Infants ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Clinical Importance ◽  
Oxygen Extraction ◽  
Loading Dose ◽  
Tissue Oxygen ◽  
Cerebral Tissue ◽  
Baseline Values ◽  
A Prospective Study

Abstract Objective The aim of this study was to evaluate the effects of caffeine on cerebral oxygenation in preterm infants. Study Design This was a prospective study of infants with a gestational age (GA) of < 34 weeks who were treated intravenously with a loading dose of 20 mg/kg caffeine citrate within the first 48 hours of life. Regional cerebral oxygen saturation (rSO2C) and cerebral fractional tissue oxygen extraction (cFTOE) were measured using near-infrared spectroscopy before administering caffeine (baseline), immediately after administering caffeine, and 1, 2, 3, 4, 6, and 12 hours after dose completion; postdose values were compared with the baseline values. Results A total of 48 infants with a mean GA of 29.0 ± 1.9 weeks, birth weight of 1,286 ± 301 g, and postnatal age of 32.4 ± 11.3 hours were included in the study. rSO2C significantly decreased from 81.3 to 76.7% soon after administering caffeine, to 77.1% at 1 hour, and to 77.8% at 2 hours with recovery at 3 hours postdose. rSO2C was 80.2% at 12 hours postdose. cFTOE increased correspondingly. Although rSO2C values were lower and cFTOE values were higher compared with the baseline values at 3, 4, 6, and 12 hours after caffeine administration, this was not statistically significant. Conclusion A loading dose of caffeine temporarily reduces cerebral oxygenation and increases cerebral tissue oxygen extraction in preterm infants. Most probably these changes reflect a physiological phenomenon without any clinical importance to the cerebral hemodynamics, as the reduction in cerebral oxygenation and increase in cerebral tissue oxygen extraction remain well within acceptable range.

Comparison of four near-infrared spectroscopy devices shows that they are only suitable for monitoring cerebral oxygenation trends in preterm infants

2014 ◽  
Vol 103 (9) ◽  
pp. 934-938 ◽  
Author(s):  
Anna Schneider ◽  
Bernd Minnich ◽  
Edda Hofstätter ◽  
Christof Weisser ◽  
Erna Hattinger-Jürgenssen ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Preterm Infants ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Oxygenation

Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis

2018 ◽  
Vol 35 (11) ◽  
pp. 1031-1037 ◽  
Author(s):  
Sara Kuik ◽  
Koenraad Van Braeckel ◽  
Jan Hulscher ◽  
Arend Bos ◽  
Elisabeth Kooi ◽  
...  
Keyword(s):  
Blood Cell ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Red Blood Cell ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Tissue Oxygen Saturation ◽  
Short Term ◽  
Diminished Capacity ◽  
Red Blood Cell Transfusions

Objective To assess intestinal and cerebral oxygenation during and after red blood cell (RBC) transfusions in preterms with or without subsequent transfusion-associated necrotizing enterocolitis (TANEC). Study Design In preterms of < 32 weeks' gestational age, we measured intestinal and cerebral regional tissue oxygen saturation (rintSO2, rcSO2) and their variabilities using near-infrared spectroscopy during and after transfusions. We compared eight infants who developed TANEC 6 to 48 hours after RBC transfusions with 16 controls. Results In TANEC infants, rcSO2 was lower during and after RBC transfusions than in controls, median (interquartile range) 55% (50–62) versus 72% (65–75), p < 0.01. There were no differences regarding rintSO2. Individual rintSO2 and rcSO2 ranges were smaller after transfusions in TANEC infants, 28% (9–36) versus 49% (40–65), p < 0.01, and 17% (14–33) versus 36% (26–57), p = 0.01, as was short-term rintSO2 variability. For each 10% higher rcSO2, the risk of developing TANEC decreased (odds ratio 0.09; 95% confidence interval 0.01–0.63). The smaller the rintSO2 range after transfusion, the higher the risk of developing TANEC. Conclusion In preterm infants lower rcSO2, but not rintSO2, values during and after RBC transfusions are associated with TANEC. Lower rintSO2 and rcSO2 variabilities after RBC transfusions may represent a diminished capacity for vascular adaptation, possibly leading to TANEC.

Noninvasive Monitoring of Cerebral Oxygenation in Preterm Infants: Preliminary Observations

PEDIATRICS ◽  
1985 ◽  
Vol 75 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Jane E. Brazy ◽  
Darrell V. Lewis ◽  
Michael H. Mitnick ◽  
Frans F. Jöbsis vander Vliet
Keyword(s):  
Preterm Infants ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Ductus Arteriosus ◽  
Infrared Light ◽  
Base Line ◽  
Transcutaneous Oxygen ◽  
Cytochrome Aa3 ◽  
In Series ◽  
Infrared Monitoring

A noninvasive optical method for bedside monitoring of cerebral oxygenation in small preterm infants was evaluated. Through differential absorbance of near infrared light, changes in the oxidation-reduction level of cytochrome aa3, in the oxygenation state of hemoglobin and in tissue blood volume were assessed in the transilluminated anterior cerebral field. Overall, cerebral oxygenated hemoglobin correlated significantly with transcutaneous oxygen, r = .44 p &lt; .0001; however, correlation was best in the absence of cardiorespiratory disease. Hypoxia with or without bradycardia led to hemoglobin deoxygenation and a shift in cytochrome aa3 to a more reduced state. When hypoxic episodes came in series or were prolonged, aa3 reduction occurred simultaneous with hemoglobin deoxygenation but its recovery to base-line values sometimes lagged behind the return of hemoglobin oxygenation. In one infant with a large patent ductus arteriosus, even brief episodes of mild bradycardia caused precipitous reduction of cytochrome aa3 before any shift to greater hemoglobin deoxygenation. This response disappeared after ductal ligation. In general, the antecedent state of cerebral oxygenation, the severity and duration of deoxygenation, and the presence or absence of circulatory abnormalities all influenced the aa3 response to hypoxia. Continuous noninvasive near infrared monitoring of cerebral oxygenation can be performed on sick preterm infants at the bedside.

scholarly journals Splanchnic-Cerebral Oxygenation Ratio Decreases during Enteral Feedings in Anemic Preterm Infants: Observations under Near-Infrared Spectroscopy

Neonatology ◽  
2017 ◽  
Vol 113 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Katherine Braski ◽  
Kimberlee Weaver-Lewis ◽  
Manndi Loertscher ◽  
Qian Ding ◽  
Xiaoming Sheng ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Preterm Infants ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Enteral Feedings
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