scholarly journals Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiationprogram

1998 ◽  
Vol 197 (6) ◽  
pp. 421-437 ◽  
Author(s):  
Z. Yablonka-Reuveni ◽  
Bodo Christ ◽  
Janice M. Benson
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Aortic Smooth Muscle ◽  
Cell Organization

Abnormal Deposition of Extracellular Matrix Proteins by Cultured Smooth Muscle Cells from Human Varicose Veins

1998 ◽  
Vol 35 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Patricia Sansilvestri-Morel ◽  
Isabelle Nonotte ◽  
Marie-Pierre Fournet-Bourguignon ◽  
Alain Rupin ◽  
Jean-Noël Fabiani ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Varicose Veins ◽  
Extracellular Matrix Proteins ◽  
Muscle Cells ◽  
Matrix Proteins ◽  
Cultured Smooth Muscle Cells

Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma

2008 ◽  
Vol 121 (5) ◽  
pp. 1196-1202 ◽  
Author(s):  
Annelies M. Slats ◽  
Kirsten Janssen ◽  
Annemarie van Schadewijk ◽  
Dirk T. van der Plas ◽  
Robert Schot ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Airway Function

scholarly journals Hyperglycemia Alters the Responsiveness of Smooth Muscle Cells to Insulin-Like Growth Factor-I

Endocrinology ◽  
2007 ◽  
Vol 148 (5) ◽  
pp. 2435-2443 ◽  
Author(s):  
Laura A. Maile ◽  
Byron E. Capps ◽  
Yan Ling ◽  
Gang Xi ◽  
David R. Clemmons
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Mapk Pathway ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Downstream Signaling ◽  
Igf I ◽  
Cell Migration And Proliferation ◽  
Stimulation Of ◽  
In Cells

IGF-I stimulation of smooth muscle cell (SMC) migration and proliferation requires αVβ3 ligand occupancy. We hypothesized that changes in the levels of extracellular matrix proteins induced by alterations in glucose concentrations may regulate the ability of SMCs to respond to IGF-I. IGF-I stimulated migration and proliferation of SMCs that had been maintained in 25 mm glucose containing media, but it had no stimulatory effect when tested using SMCs that had been grown in 5 mm glucose. IGF-I stimulated an increase in Shc phosphorylation and enhanced activation of the MAPK pathway in SMCs grown in 25 mm glucose, whereas in cells maintained in 5 mm glucose, IGF-I had no effect on Shc phosphorylation, and the MAPK response to IGF-I was markedly reduced. In cells grown in 25 mm glucose, the levels of αVβ3 ligands, e.g. osteopontin, vitronectin, and thrombospondin, were all significantly increased, compared with cells grown in 5 mm glucose. The addition of these αVβ3 ligands to SMCs grown in 5 mm glucose was sufficient to permit IGF-I-stimulated Shc phosphorylation and downstream signaling. Because we have shown previously that αVβ3 ligand occupancy is required for IGF-I-stimulated Shc phosphorylation and stimulation of SMC growth, our data are consistent with a model in which 25 mm glucose stimulates increases in the concentrations of these extracellular matrix proteins, thus enhancing αVβ3 ligand occupancy, which leads to increased Shc phosphorylation and enhanced cell migration and proliferation in response to IGF-I.

Cholesterol loading in vivo and in vitro alters extracellular matrix proteins production in smooth muscle cells

2015 ◽  
Vol 118 (9) ◽  
pp. 1317-1325
Author(s):  
Rogelio Palomino-Morales ◽  
Sonia Perales ◽  
Carolina Torres ◽  
Ana Linares ◽  
Maria Jose Alejandre
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Extracellular Matrix Proteins ◽  
Muscle Cells ◽  
Matrix Proteins
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