scholarly journals Expansion of mossy fibers and CA3 apical dendritic length accompanies the fall in dendritic spine density after gonadectomy in male, but not female, rats

2016 ◽  
Vol 222 (1) ◽  
pp. 587-601 ◽  
Author(s):  
Ari L. Mendell ◽  
Sarah Atwi ◽  
Craig D. C. Bailey ◽  
Dan McCloskey ◽  
Helen E. Scharfman ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Mossy Fibers ◽  
Female Rats ◽  
Spine Density ◽  
Dendritic Length ◽  
Dendritic Spine Density

scholarly journals Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats

2015 ◽  
Vol 69 ◽  
pp. 89-97 ◽  
Author(s):  
Rachel E. Bowman ◽  
Victoria Luine ◽  
Samantha Diaz Weinstein ◽  
Hameda Khandaker ◽  
Sarah DeWolf ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adult Male ◽  
Dendritic Spine ◽  
Female Rats ◽  
Spine Density ◽  
Male And Female ◽  
Dendritic Spine Density ◽  
Male And Female Rats

scholarly journals Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc

2019 ◽  
Author(s):  
Brendan B. McAllister ◽  
Sarah E. Thackray ◽  
Brenda Karina Garciá de la Orta ◽  
Elise Gosse ◽  
Purnoor Tak ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Knockout Mice ◽  
Environmental Enrichment ◽  
Basolateral Amygdala ◽  
Barrel Cortex ◽  
Zinc Transporter ◽  
Neuronal Morphology ◽  
Spine Density ◽  
Dendritic Length ◽  
Dendritic Spine Density

ABSTRACTIn the central nervous system, certain neurons store zinc within the synaptic vesicles of their axon terminals. This vesicular zinc can then be released in an activity-dependent fashion as an intercellular signal. The functions of vesicular zinc are not entirely understood, but evidence suggests that it is important for some forms of experience-dependent plasticity in the brain. The ability of neurons to store and release vesicular zinc is dependent on expression of the vesicular zinc transporter, ZnT3. Here, we examined the neuronal morphology of mice that lack ZnT3. Brains were collected from mice housed under standard laboratory conditions and from mice housed in enriched environments – large, multilevel enclosures with running wheels, numerous objects and tunnels, and a greater number of cage mates. Golgi-Cox staining was used to visualize neurons for analysis of dendritic length and dendritic spine density. Neurons were analyzed from the barrel cortex, striatum, basolateral amygdala, and hippocampus (CA1). ZnT3 knockout mice, relative to wild type mice, exhibited increased basal dendritic length in the layer 2/3 pyramidal neurons of barrel cortex, independently of housing condition. Environmental enrichment decreased apical dendritic length in these same neurons and increased dendritic spine density on striatal medium spiny neurons. Elimination of ZnT3 did not modulate any of the effects of enrichment. Our results provide no evidence that vesicular zinc is required for the experience-dependent changes that occur in response to environmental enrichment. They are consistent, however, with recent reports suggesting increased cortical volume in ZnT3 knockout mice.

scholarly journals miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline

2018 ◽  
Vol 19 (8) ◽  
pp. 2323 ◽  
Author(s):  
Yu-Chia Kao ◽  
I-Fang Wang ◽  
Kuen-Jer Tsai
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Memory Impairment ◽  
Memory Formation ◽  
Spine Density ◽  
Memory Decline ◽  
Dendritic Length ◽  
Dendritic Spine Density ◽  
Key Sites ◽  
And Storage

Microribonucleic acids (miRNAs) play a pivotal role in numerous aspects of the nervous system and are increasingly recognized as key regulators in neurodegenerative diseases. This study hypothesized that miR-34c, a miRNA expressed in mammalian hippocampi whose expression level can alter the hippocampal dendritic spine density, could induce memory impairment akin to that of patients with Alzheimer’s disease (AD) in mice. In this study, we showed that miR-34c overexpression in hippocampal neurons negatively regulated dendritic length and spine density. Hippocampal neurons transfected with miR-34c had shorter dendrites on average and fewer filopodia and spines than those not transfected with miR-34c (control mice). Because dendrites and synapses are key sites for signal transduction and fundamental structures for memory formation and storage, disrupted dendrites can contribute to AD. Therefore, we supposed that miR-34c, through its effects on dendritic spine density, influences synaptic plasticity and plays a key role in AD pathogenesis.

scholarly journals Five hours total sleep deprivation does not affect CA1 dendritic length or spine density

2021 ◽  
Author(s):  
Alvin T.S. Brodin ◽  
Sarolta Gabulya ◽  
Katrin Wellfelt ◽  
Tobias E. Karlsson
Keyword(s):  
Sleep Deprivation ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Memory Function ◽  
Long Term Memory ◽  
Spine Density ◽  
Dendritic Length ◽  
Dendritic Spine Density ◽  
Hippocampal Ca1

AbstractSleep is essential for long term memory function. However the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that five hours of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from one episode of sleep deprivation.

scholarly journals Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Victoria N. Luine ◽  
Maureen E. Wallace ◽  
Maya Frankfurt
Keyword(s):  
Spatial Memory ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Female Rats ◽  
Spine Density ◽  
Fischer 344 ◽  
Dendritic Spine Density ◽  
Basal Dendrites ◽  
Young Subjects ◽  
Aged Subjects

Effects of aging on memory and brain morphology were examined in aged, 21-month-old, and young, 4-month-old, Fischer 344 female rats. Spatial memory was assessed using the object placement task, and dendritic spine density was determined on pyramidal neurons in the hippocampus following Golgi impregnation. Consistent with previous studies, aged females showed poorer object placement performance than young subjects. Young subjects significantly discriminated the location of objects with a 1.5-hour intertrial delay while aged subjects did not. Spine density of basal dendrites on CA1 pyramidal cells was 16% lower in the aged subjects as compared to the young subjects. No differences in spine density were found between young and aged subjects in basal dendrites of CA1 or in either dendritic field of CA3 pyramidal neurons. Thus, decreased hippocampal CA1 dendritic spine density in aged rats may contribute to poorer spatial memory as compared to young rats. The possibility that the neuroplastic changes observed in this study may pertain only to female subjects having had a specific set of life experiences is discussed. Different factors, such as reproductive status, diet, and handling may contribute to neuroplasticity of the brain during aging; however, this view requires further examination.

scholarly journals FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner

2021 ◽  
pp. 105253
Author(s):  
Katherine M. Bland ◽  
Adam Aharon ◽  
Eden L. Widener ◽  
M. Irene Song ◽  
Zachary O. Casey ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Subcellular Distribution ◽  
Spine Density ◽  
Dendritic Spine Density
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