Glomerular handling of immune complex in the acute phase of active in situ immune complex glomerulonephritis employing cationized ferritin in rats

1997 ◽  
Vol 431 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Y. Fujigaki ◽  
Mitsumasa Nagase ◽  
Kenichiro Kojima ◽  
Tatsuo Yamamoto ◽  
Akira Hishida
Keyword(s):  
Immune Complex ◽  
Acute Phase ◽  
Cationized Ferritin ◽  
Immune Complex Glomerulonephritis

The Electrophoretic Pattern of Urinary Protein in in situ Immune Complex Glomerulonephritis

Nephron ◽  
1988 ◽  
Vol 50 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Tetsuo Morioka ◽  
Hiroshi Sugano ◽  
Katsuyuki Matsui ◽  
Shoji Kagami ◽  
Fujio Shimizu ◽  
...  
Keyword(s):  
Immune Complex ◽  
Electrophoretic Pattern ◽  
Urinary Protein ◽  
Immune Complex Glomerulonephritis

Ultrastructural studies in passive in situ immune complex glomerulonephritis

1989 ◽  
Vol 58 (1) ◽  
pp. 173-180 ◽  
Author(s):  
M. Sasaki ◽  
S. Batsford ◽  
F. Thaiss ◽  
T. Oite ◽  
A. Vogt
Keyword(s):  
Immune Complex ◽  
Immune Complex Glomerulonephritis ◽  
Ultrastructural Studies

Cell-to-cell interaction is required to induce proteinuria in in situ immune complex glomerulonephritis

1998 ◽  
Vol 132 (2) ◽  
pp. 112-123 ◽  
Author(s):  
Takako Oda ◽  
Masato Kimura ◽  
Akira Hishida ◽  
Akira Yamashita ◽  
Yasuo Suzuki ◽  
...  
Keyword(s):  
Immune Complex ◽  
Cell Interaction ◽  
Immune Complex Glomerulonephritis

Chemokine and Chemokine Receptor Expression during Initiation and Resolution of Immune Complex Glomerulonephritis

2001 ◽  
Vol 12 (5) ◽  
pp. 919-931 ◽  
Author(s):  
HANS-JOACHIM ANDERS ◽  
VOLKER VIELHAUER ◽  
MATTHIAS KRETZLER ◽  
CLEMENS D. COHEN ◽  
STEPHAN SEGERER ◽  
...  
Keyword(s):  
Immune Complex ◽  
Chemokine Receptors ◽  
Receptor Expression ◽  
Leukocyte Infiltration ◽  
Glomerular Injury ◽  
Monocyte Chemoattractant Protein 1 ◽  
Immune Complex Glomerulonephritis ◽  
Reverse Transcription Pcr ◽  
Cell Expression

Abstract. Chemokines participate in leukocyte infiltration, which plays a major role in glomerular injury during immune complex glomerulonephritis (IC-GN). Because target cell expression of chemokine receptors (CCR) is thought to mediate leukocyte migration, the expression pattern of chemokines and CCR in a model of IC-GN was examined. The transient course and predominant glomerular pathology of this model allows the examination of both the induction and resolution phases of IC-GN. GN was induced in mice by daily apoferritin injection for 2 wk. Urine samples and kidneys were obtained at 1, 2, and 4 wk. Albuminuria was noted at 2 wk, but resolved after 4 wk. This was associated with glomerular IC deposits and mesangial proliferation. Glomerular macrophage infiltration was prominent at 1 and 2 wk, which resolved at 4 wk. Expression of monocyte chemoattractant protein-1 (MCP-1) and RANTES mRNA was upregulated at week 1 and decreased to control levels at weeks 2 and 4. The expression was localized to glomeruli byin situhybridization and immunohistochemistry. The mRNA of CCR1, CCR2, and CCR5 but not CCR3 or CCR4 were upregulated at week 1 and decreased at weeks 2 and 4. Expression of CCR5 was located to the glomerulus byin situhybridization and quantitative reverse transcription-PCR of isolated glomeruli. In summary, in a model of transient IC-GN, MCP-1 and RANTES and their receptors CCR1, CCR2, and CCR5 are expressed early and are already downregulated at the peak of proteinuria and leukocyte infiltration. Resolution of glomerulonephritis is associated with a return to baseline of chemokine and CCR expression. Therefore, it is concluded that glomerular MCP-1 and RANTES production directs circulating leukocytes that express CCR1, CCR2, and CCR5 into the glomerulus. After initiating GN, MCP-1 and RANTES and their receptors are readily downregulated.

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