Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma

1997 ◽  
Vol 430 (6) ◽  
pp. 461-466 ◽  
Author(s):  
N.-H. Chow ◽  
Hsiao-Sheng Liu ◽  
Hsiao-Bai Yang ◽  
Shih-Huang Chan ◽  
Ih-Jen Su
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Expression Patterns ◽  
Transitional Cell ◽  
Erbb Receptor ◽  
Erbb Receptor Family ◽  
Normal Urothelium ◽  
Receptor Family

Expression of Cyclooxygenase-2 in Normal Urothelium, and Superficial and Advanced Transitional Cell Carcinoma of Bladder

2007 ◽  
Vol 177 (3) ◽  
pp. 1163-1168 ◽  
Author(s):  
Vitaly Margulis ◽  
Shahrokh F. Shariat ◽  
Raheela Ashfaq ◽  
Melissa Thompson ◽  
Arthur I. Sagalowsky ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Cyclooxygenase 2 ◽  
Normal Urothelium

scholarly journals Lipoxygenase-5 Expression in Canine Urinary Bladder: Normal Urothelium, Cystitis and Transitional Cell Carcinoma

2019 ◽  
Vol 170 ◽  
pp. 1-9 ◽  
Author(s):  
Riccardo Finotello ◽  
Luca Schiavo ◽  
Lorenzo Ressel ◽  
Ava Frohmader ◽  
Paolo Silvestrini ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Normal Urothelium

scholarly journals Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Yuh-Shyan Tsai ◽  
Hong-Lin Cheng ◽  
Tzong-Shin Tzai ◽  
Nan-Haw Chow
Keyword(s):  
Bladder Cancer ◽  
Clinical Trials ◽  
Urothelial Carcinoma ◽  
Cox Regression ◽  
Meta Analysis ◽  
Expression Patterns ◽  
Receptor Expression ◽  
Erbb Receptor ◽  
Erbb Receptor Family ◽  
Receptor Family

The prognostic importance of examining ErbB receptor family expression in human bladder cancer remains uncertain. Using published evidence, we examined the clinical value and the updated results of clinical trials targeting ErbB receptor family members. Twenty-seven articles from 65 references related to ErbB receptor expression assessment in bladder cancer were reviewed. The estimates included the association significance, hazard ratios, and 95% confidence intervals (CIs) from actuarial curves and survival analyses. A meta-analysis was done on those reports using univariate log-rank tests or a Cox-regression model. The methods of analysis and study subjects chosen varied widely among studies. The overall risks of disease progression for patients with EGFR or ErbB2 overexpression were 4.5 (95% CI: 2.5–8.4) and 1.1 (95% CI: 0.6–1.9), and the risks of mortality were 3.0 (95% CI: 1.6–5.9) and 1.1 (95% CI: 1.0–1.2), respectively. However, the significance of coexpression patterns of the ErbB receptor family remains controversial. None of six clinical trials yielded convincing results for blockading ErbB receptor signaling in urothelial carcinoma. The results of this analysis suggest that assessing co-expression patterns of the ErbB family may provide better prognostic information for bladder cancer patients.

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