Continuous recruitment, co-expression of tumour necrosis factor-α and matrix metalloproteinases, and apoptosis of macrophages in gout tophi

S. Schweyer; B. Hemmerlein; H.J. Radzun; A. Fayyazi

doi:10.1007/s004280000282

Continuous recruitment, co-expression of tumour necrosis factor-α and matrix metalloproteinases, and apoptosis of macrophages in gout tophi

Virchows Archiv ◽

10.1007/s004280000282 ◽

2000 ◽

Vol 437 (5) ◽

pp. 534-539 ◽

Cited By ~ 50

Author(s):

S. Schweyer ◽

B. Hemmerlein ◽

H.J. Radzun ◽

A. Fayyazi

Keyword(s):

Matrix Metalloproteinases ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Α ◽

Factor Α ◽

Gout Tophi ◽

Necrosis Factor

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Substrate specificity and inducibility of TACE (tumour necrosis factor α-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity

Biochemical Society Symposium ◽

10.1042/bss0700039 ◽

2003 ◽

Vol 70 ◽

pp. 39-52 ◽

Cited By ~ 54

Author(s):

Roy A. Black ◽

John R. Doedens ◽

Rajeev Mahimkar ◽

Richard Johnson ◽

Lin Guo ◽

...

Keyword(s):

Substrate Specificity ◽

Recent Work ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Transforming Growth Factor ◽

Intrinsic Activity ◽

Converting Enzyme ◽

Tumour Necrosis Factor Α ◽

Factor Α ◽

Necrosis Factor

Tumour necrosis factor α (TNFα)-converting enzyme (TACE/ADAM-17, where ADAM stands for a disintegrin and metalloproteinase) releases from the cell surface the extracellular domains of TNF and several other proteins. Previous studies have found that, while purified TACE preferentially cleaves peptides representing the processing sites in TNF and transforming growth factor α, the cellular enzyme nonetheless also sheds proteins with divergent cleavage sites very efficiently. More recent work, identifying the cleavage site in the p75 TNF receptor, quantifying the susceptibility of additional peptides to cleavage by TACE and identifying additional protein substrates, underlines the complexity of TACE-substrate interactions. In addition to substrate specificity, the mechanism underlying the increased rate of shedding caused by agents that activate cells remains poorly understood. Recent work in this area, utilizing a peptide substrate as a probe for cellular TACE activity, indicates that the intrinsic activity of the enzyme is somehow increased.

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Tumour necrosis factor-α production significantly increased in coeliac disease is not associated with the TNFa2 microsatellite polymorphism

Immunology Letters ◽

10.1016/s0165-2478(97)86992-1 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 40-41

Author(s):

J Daly

Keyword(s):

Coeliac Disease ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Microsatellite Polymorphism ◽

Tumour Necrosis Factor Α ◽

Factor Α ◽

Necrosis Factor

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Faculty Opinions recommendation of Alopecia areata as another immune-mediated disease developed in patients treated with tumour necrosis factor-α blocker agents: Report of five cases and review of the literature.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6679956.6834054 ◽

2010 ◽

Author(s):

Francisco Camacho

Keyword(s):

Tumour Necrosis Factor ◽

Alopecia Areata ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Α ◽

Review Of The Literature ◽

Immune Mediated ◽

Factor Α ◽

Necrosis Factor

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Knockdown of Tumour Necrosis Factor-α-Induced Protein 8-Like 2 Promotes Normal and Diabetic Corneal Epithelial Wound Healing and Attenuates Corneal Apoptosis via Upregulation of Nuclear Factor-κB p50

SSRN Electronic Journal ◽

10.2139/ssrn.3436235 ◽

2019 ◽

Author(s):

Weina Li ◽

Xiaochuan Wang ◽

Qingjun Zhou ◽

Qingguo Ruan ◽

Jing Li ◽

...

Keyword(s):

Wound Healing ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Nuclear Factor Κb ◽

Nuclear Factor ◽

Tumour Necrosis Factor Α ◽

Corneal Epithelial ◽

Epithelial Wound Healing ◽

Factor Α ◽

Necrosis Factor

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Protective effect of NG-monomethyl-L-arginine against hypotension inducted by combined tumour necrosis factor-α and whole body hyperthermia in rats

International Journal of Hyperthermia ◽

10.3109/02656739609027670 ◽

1996 ◽

Vol 12 (5) ◽

pp. 617-634 ◽

Cited By ~ 1

Author(s):

M. Makino ◽

R. F. Lodato ◽

L. C. Stephens ◽

F. R. Strebel ◽

G. Jenkins ◽

...

Keyword(s):

Protective Effect ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Whole Body ◽

Tumour Necrosis Factor Α ◽

Whole Body Hyperthermia ◽

Factor Α ◽

Necrosis Factor

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Successful resolution of pneumonia developed in a patient affected by Crohn’s disease, rheumatoid arthritis, myasthenia gravis and recurrent uveitis during concomitant treatment with tumour necrosis factor α inhibitors and conventional immunosuppressive drugs

Rheumatology International ◽

10.1007/s00296-009-1012-6 ◽

2009 ◽

Vol 30 (7) ◽

pp. 977-978 ◽

Cited By ~ 4

Author(s):

Erika Angelucci ◽

Monica Cesarini ◽

Piero Vernia

Keyword(s):

Rheumatoid Arthritis ◽

Myasthenia Gravis ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Immunosuppressive Drugs ◽

Concomitant Treatment ◽

Tumour Necrosis Factor Α ◽

Successful Resolution ◽

Factor Α ◽

Necrosis Factor

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Serum levels of tumour necrosis factor-α predict response to recombinant human erythropoietin in patients with myelodysplastic syndrome

Clinical & Laboratory Haematology ◽

10.1111/j.1365-2257.1997.tb00007.x ◽

1997 ◽

Vol 19 (3) ◽

pp. 197-201 ◽

Cited By ~ 29

Author(s):

R. STASI ◽

M. BRUNETTI ◽

S. BUSSA ◽

M. CONFORTI ◽

L. S. MARTIN ◽

...

Keyword(s):

Myelodysplastic Syndrome ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Recombinant Human Erythropoietin ◽

Serum Levels ◽

Tumour Necrosis Factor Α ◽

Human Erythropoietin ◽

Factor Α ◽

Necrosis Factor

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Bacterial lipoprotein induces tolerance in human THP-1 monocytes with reduced tumour necrosis factor α production via a CD14-independent pathway

British Journal of Surgery ◽

10.1046/j.1365-2168.2000.01544-3.x ◽

2000 ◽

Vol 87 (7) ◽

pp. 932-933 ◽

Cited By ~ 1

Author(s):

M. Doyle ◽

J. H. Wang ◽

Q. D. Wu ◽

S. Blankson ◽

H. P. Redmond

Keyword(s):

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Α ◽

Factor Α ◽

Necrosis Factor ◽

Bacterial Lipoprotein

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FLOW CYTOMETRICAL DETERMINATION OF INTERLEUKIN 1β, INTERLEUKIN 6 AND TUMOUR NECROSIS FACTOR α IN MONOCYTES OF RHEUMATOID ARTHRITIS PATIENTS; RELATION WITH PARAMETERS OF OSTEOPOROSIS

Cytokine ◽

10.1006/cyto.1998.0500 ◽

1999 ◽

Vol 11 (11) ◽

pp. 869-874 ◽

Cited By ~ 12

Author(s):

Ann Verbruggen ◽

Luc S De Clerck ◽

Chris H Bridts ◽

Jan F Van Offel ◽

Wim J Stevens

Keyword(s):

Rheumatoid Arthritis ◽

Tumour Necrosis Factor ◽

Interleukin 6 ◽

Tumour Necrosis ◽

Interleukin 1Β ◽

Tumour Necrosis Factor Α ◽

Factor Α ◽

Necrosis Factor

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Tumour necrosis factor α receptors: role in the physiopathology of protozoan parasite infections

International Journal for Parasitology ◽

10.1016/s0020-7519(01)00194-1 ◽

2001 ◽

Vol 31 (8) ◽

pp. 763-769 ◽

Cited By ~ 21

Author(s):

Dorra Derouich-Guergour ◽

Marie-Pierre Brenier-Pinchart ◽

Pierre Ambroise-Thomas ◽

Hervé Pelloux

Keyword(s):

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Protozoan Parasite ◽

Tumour Necrosis Factor Α ◽

Parasite Infections ◽

Factor Α ◽

Necrosis Factor

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