Patterns of keratin polypeptides in 110 biphasic, monophasic, and poorly differentiated synovial sarcomas

Synovial sarcoma is a malignant mesenchymal tumor most commonly occurring in the extremities, but is occasionally seen in the trunk, head, and neck regions. The well developed lesion exhibits a distinct biphasic histologic morphology consisting of a spindle cell fibrosarcomatous stroma and epithelial-lined pseudoacinar structures with an associated mucopolysaccharide secretion. The presence of this biphasic pattern is dependent upon the degree of histologic differentiation. Few studies of the fine structure of synovial sarcomas are available and none of the literature has been concerned with these neoplasms occurring in the less common areas. The ultrastructural features of a tumor classified as a poorly differentiated synovial sarcoma are presented.A mass of irregularly shaped, cerebreform tissue was surgically removed from the left side of the neck of a 61 year old white male. The majority of the tissue was fixed in neutral buffered formalin and prepared for light microscopy.

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Intraneural Synovial Sarcoma of the Median Nerve in a 15-Year-Old Male: A Case Report and Review of Literature

Hand ◽

10.1177/1558944720975139 ◽

2021 ◽

pp. 155894472097513

Author(s):

Arthur Samia ◽

Joshua Scarcella ◽

Richard Zeri ◽

Yifan Guo

Keyword(s):

Median Nerve ◽

Synovial Sarcoma ◽

Thenar Eminence ◽

Right Hand ◽

History Of ◽

Synovial Sarcomas ◽

Poorly Differentiated ◽

Web Space ◽

The Right

There have been 8 synovial sarcomas of the median nerve reported. We report a case of a 15-year-old male with synovial sarcoma of the right-hand median nerve. Patient presented with a 2-month history of enlarging mass at the base of the right thenar eminence associated with numbness in the median nerve distribution. Physical examination revealed a soft mass over the thenar eminence and paresthesia in the median nerve distribution. He underwent excision of the tumor, which revealed a well-encapsulated lesion encompassing the median nerve, involving the first, second, and radial aspect of the third web space as well as recurrent branches of the median nerve. Following excision of the tumor, a thorough metastatic workup was negative for metastatic disease. He was staged as III, T2b, N0, M0—poorly differentiated monophasic synovial sarcoma of the right median nerve. Postoperatively the patient was started on chemotherapy and radiation. Intraneural synovial sarcoma is extremely rare. Our case is the youngest with the longest follow-up. He is currently at a status of 3 years posttreatment with no signs of recurrence and excellent use of his right hand. This case is of particular interest due to the rarity of the disease along with this being the best outcome reported in the literature to-date.

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Primary Pulmonary Poorly Differentiated Synovial Sarcoma: Transducer-Like Enhancer of Split 1 Immunohistochemistry as A Valuable Diagnostic Aid

Journal of Laboratory Physicians ◽

10.4103/0974-2727.115922 ◽

2013 ◽

Vol 5 (01) ◽

pp. 55-57

Author(s):

Amulyajit Kaur ◽

Henry Dale Tazelaar ◽

Kavita Sahai

Keyword(s):

Synovial Sarcoma ◽

Gold Standard ◽

Fusion Gene ◽

Young Individual ◽

Diagnostic Aid ◽

Synovial Sarcomas ◽

Poorly Differentiated ◽

Enhancer Of Split

ABSTRACTPoorly differentiated primary pulmonary synovial sarcomas are rare and challenging for a surgical pathologist to diagnose. Although the demonstration of the tumor specific translocation, t (x; 18)(p11.2;q11.2) or the resultant fusion gene (SYT-SSX) is the gold standard for diagnosis, this test is not always accessible. We report the use of immunohistochemistry, including transducer-like enhancer of split-1 in the diagnosis of one such tumor in a young individual.

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Primary Synovial Sarcoma of Kidney: A Rare Differential Diagnosis of Renomegaly

Case Reports in Pathology ◽

10.1155/2014/657497 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Gaurang Modi ◽

Irappa Madabhavi ◽

Harsha Panchal ◽

Asha Anand ◽

Apurva Patel ◽

...

Keyword(s):

Poor Prognosis ◽

Renal Mass ◽

Epithelial Membrane Antigen ◽

Palliative Chemotherapy ◽

Soft Tissue Sarcomas ◽

Rare Differential Diagnosis ◽

Rare Tumours ◽

Synovial Sarcomas ◽

Poorly Differentiated ◽

Histology And Immunohistochemistry

Synovial sarcomas (SS) are classified as subgroup of soft tissue sarcomas affecting mainly extremities of young adults. Primary SS of kidney are very rare tumours with poor prognosis. Though they have characteristic histology and immunohistochemistry (IHC) due to rarity of incidence it is difficult to diagnose them. Sometimes chromosomal rearrangement studies are required to confirm the diagnosis. We are presenting a case of 41-year-old male who was referred to our cancer centre for evaluation of left renal mass. CT scan of abdomen revealed a large left renal mass encasing the aorta. Biopsy of renal mass revealed poorly differentiated sarcoma and IHC was positive for vimentin, CD99, and BCL2 and negative for AE1, epithelial membrane antigen, and leukocyte common antigen. The patient was clinically inoperable as renal mass was encasing the aorta. So he was subsequently offered palliative chemotherapy in form of ifosfamide and adriamycin. CT abdomen shows partial response after 3 cycles of chemotherapy according to RECIST criteria.

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Poorly differentiated synovial sarcoma of the sphenoid sinus: report of the first case and review of synovial sarcomas of the sinonasal tract

Histopathology ◽

10.1111/j.1365-2559.2012.04340.x ◽

2012 ◽

Vol 61 (6) ◽

pp. 1232-1237 ◽

Cited By ~ 9

Author(s):

Manish M Subramaniam ◽

Chao S Shuen ◽

Fredrik Petersson

Keyword(s):

Synovial Sarcoma ◽

Sphenoid Sinus ◽

Sinonasal Tract ◽

First Case ◽

Synovial Sarcomas ◽

Poorly Differentiated

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Motility of leukemic lymphocytes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100159382 ◽

1990 ◽

Vol 48 (3) ◽

pp. 368-369

Author(s):

Manoj Raje ◽

Karvita B. Ahluwalia

Keyword(s):

Quantitative Data ◽

Laser Doppler Velocimetry ◽

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

Cellular Space ◽

Differentiated Cells ◽

Poorly Differentiated ◽

Solid Tissues ◽

Well Differentiated ◽

Reduced Mobility

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

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