Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance

2000 ◽  
Vol 437 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Valdemar Máximo ◽  
M. Sobrinho-Simões
Keyword(s):  
Clinical Relevance ◽  
Mitochondrial Abnormalities ◽  
Hürthle Cell ◽  
Hürthle Cell Tumours

scholarly journals The biology and the genetics of Hürthle cell tumors of the thyroid

2012 ◽  
Vol 19 (4) ◽  
pp. R131-R147 ◽  
Author(s):  
Valdemar Máximo ◽  
Jorge Lima ◽  
Hugo Prazeres ◽  
Paula Soares ◽  
Manuel Sobrinho-Simões
Keyword(s):  
Cell Transformation ◽  
Experimental Models ◽  
Molecular Evidence ◽  
Compensatory Mechanism ◽  
Mitochondrial Abnormalities ◽  
Mtdna Mutations ◽  
Hürthle Cell ◽  
Large Deletions ◽  
Hürthle Cell Tumors ◽  
The Comparative Study

The biology and the genetics of Hürthle cell tumors are reviewed starting from the characterization and differential diagnosis of the numerous benign and malignant, neoplastic and nonneoplastic lesions of the thyroid in which Hürthle cell transformation is frequently observed. The clinicopathologic and molecular evidence obtained from the comparative study of the aforementioned conditions indicate that Hürthle cell appearance represents a phenotype that is superimposed on the genotypic and conventional histopathologic features of the tumors. Hürthle cell tumors differ from their non-Hürthle counterparts regarding the prevalence of large deletions of mitochondrial DNA (mtDNA), mutations of mtDNA genes coding for oxidative phosphorylation (OXPHOS) proteins (namely mutations of complex I subunit genes) and mutations of nuclear genes coding also for mitochondrial OXPHOS proteins. Such mitochondrial alterations lead to energy production defects in Hürthle cell tumors; the increased proliferation of mitochondria may reflect a compensatory mechanism for such defects and is associated with the overexpression of factors involved in mitochondrial biogenesis. The mitochondrial abnormalities are also thought to play a major role in the predisposition for necrosis instead of apoptosis which seems to be blocked in most Hürthle cell tumors. Finally, the results obtained in experimental models using cybrid cell lines and the data obtained from histopathologic and molecular studies of familial Hürthle cell tumors are used, together with the aforementioned genetic and epigenetic alterations, to progress in the understanding of the mechanisms through which mitochondrial abnormalities may be involved in the different steps of thyroid carcinogenesis, from tumor initiation to metastization.

Surgery for thyroid Hürthle cell tumours—a single institution experience

2006 ◽  
Vol 32 (4) ◽  
pp. 458-461 ◽  
Author(s):  
I. Paunovic ◽  
K. Krgovic ◽  
S. Tatic ◽  
A. Diklic ◽  
V. Zivaljevic ◽  
...  
Keyword(s):  
Single Institution ◽  
Hürthle Cell ◽  
Hürthle Cell Tumours

Selected Abstracts of Recent Research in Stuttering

1999 ◽  
Vol 9 (1) ◽  
pp. 5-6
Author(s):  
Carrie Bain ◽  
Nan Bernstein Ratner
Keyword(s):  
Large Volume ◽  
Clinical Relevance

Due to the large volume of fluency-related publications since the last column, we have chosen to highlight those articles of highest potential clinical relevance.

259: Evaluation and Clinical Relevance of Prognostic Molecular Risk Factors in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 86-86
Author(s):  
Roland Bonfig ◽  
Hubertus Riedmiller ◽  
Burkhardt Kneitz ◽  
Philipp Stroebel
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Clinical Relevance

52: Clinical Relevance of Local Recurrence in Neobladders

2004 ◽  
Vol 171 (4S) ◽  
pp. 14-14
Author(s):  
Dieter R. Echtle ◽  
Elizabeth M. Mueller ◽  
Detlef H. Frohneberg
Keyword(s):  
Local Recurrence ◽  
Clinical Relevance
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