Blockade of the delayed rectifier K + currents, I Kr , in rabbit sinoatrial node cells by external divalent cations

1999 ◽  
Vol 438 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Dae-Kyu Song ◽  
Yung E. Earm ◽  
W.-K. Ho
Keyword(s):  
Sinoatrial Node ◽  
Divalent Cations ◽  
Delayed Rectifier ◽  
Sinoatrial Node Cells ◽  
Rabbit Sinoatrial Node ◽  
K Currents

A rapidly activating delayed rectifier K+ channel in rabbit sinoatrial node cells

1995 ◽  
Vol 269 (2) ◽  
pp. H443-H452 ◽  
Author(s):  
H. Ito ◽  
K. Ono
Keyword(s):  
Steady State ◽  
Sinoatrial Node ◽  
Single Channel ◽  
Ensemble Average ◽  
Negative Slope ◽  
Delayed Rectifier ◽  
Channel Current ◽  
Single Channel Current ◽  
Sinoatrial Node Cells ◽  
Rabbit Sinoatrial Node

The single-channel current of the delayed rectifier K+ current (IK) was recorded in rabbit sinoatrial node cells. In the cell-attached patch, depolarization from -70 mV to potentials more positive than -50 mV activated the IK channel while repolarization deactivated it. The single-channel conductance was 7.8 pS for the outward current and 10.8 pS for the inward current (n = 6). The steady-state open probability (NPo) was maximum at around -30 mV and markedly decreased at more positive potentials. On repolarization from positive potentials, the channel was initially closed and then rapidly opened. The ensemble average showed an initial rise to a peak followed by the deactivation time course. Because the channel events were completely blocked by E-4031, the drug-sensitive component was examined in the whole cell current. The steady-state current-voltage relation of the drug-sensitive current showed a marked negative slope at potentials more positive than -10 mV. Upon repolarization, the drug-sensitive current initially increased (removal of inactivation) to the peak of the outward tail current, which was in agreement with the ensemble average of the single-channel current. We conclude that IK in the sinoatrial node cells is largely composed of the rapidly activating IK (IK,r) channels and that the inward rectification of IK,r, which is more marked than had been assumed in previous studies, is due to the decrease in NPo.

scholarly journals Electrophysiological analysis of the negative chronotropic effect of endothelin‐1 in rabbit sinoatrial node cells

2001 ◽  
Vol 537 (2) ◽  
pp. 467-488 ◽  
Author(s):  
Kageyoshi Ono ◽  
Haruko Masumiya ◽  
Aiji Sakamoto ◽  
Georges Christé ◽  
Toshinori Shijuku ◽  
...  
Keyword(s):  
Sinoatrial Node ◽  
Chronotropic Effect ◽  
Endothelin 1 ◽  
Negative Chronotropic Effect ◽  
Electrophysiological Analysis ◽  
Sinoatrial Node Cells ◽  
Rabbit Sinoatrial Node

Ionic Currents in Rabbit Sinoatrial Node Cells

1978 ◽  
pp. 301-310 ◽  
Author(s):  
Akinori Noma ◽  
Kaoru Yanagihara ◽  
Hiroshi Irisawa
Keyword(s):  
Sinoatrial Node ◽  
Ionic Currents ◽  
Sinoatrial Node Cells ◽  
Rabbit Sinoatrial Node

scholarly journals Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells

2009 ◽  
Vol 105 (1) ◽  
pp. 73-87 ◽  
Author(s):  
Marcel M. G. J. Borren ◽  
Arie O. Verkerk ◽  
Ronald Wilders ◽  
Najat Hajji ◽  
Jan G. Zegers ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Sinoatrial Node ◽  
Camp Production ◽  
Receptor Stimulation ◽  
Sinoatrial Node Cells ◽  
Rabbit Sinoatrial Node

Electrophysiological effects of amrinone on the automaticity and membrane current system of the rabbit sinoatrial node cells

1998 ◽  
Vol 13 (3) ◽  
pp. 114-121 ◽  
Author(s):  
Tadayoshi Hata ◽  
Masao Nishimura ◽  
Kayo Ogino ◽  
Hirohide Uchiyama ◽  
Yoshio Watanabe
Keyword(s):  
Sinoatrial Node ◽  
Current System ◽  
Membrane Current ◽  
Sinoatrial Node Cells ◽  
Rabbit Sinoatrial Node ◽  
Electrophysiological Effects
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