Gender- and age-related differences in the regulatory influence of thyroid hormone on the contractility and myosin composition of single rat soleus muscle fibres

1998 ◽  
Vol 437 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Fushun Yu ◽  
Hans Degens ◽  
Xiaopeng Li ◽  
L. Larsson
Keyword(s):  
Thyroid Hormone ◽  
Soleus Muscle ◽  
Muscle Fibres ◽  
Regulatory Influence ◽  
Age Related ◽  
Gender And Age ◽  
Rat Soleus Muscle

Thyroid hormone-induced upregulation of Na+ channels and Na+-K+pumps: implications for contractility

1998 ◽  
Vol 274 (3) ◽  
pp. R864-R867 ◽  
Author(s):  
A. P. Harrison ◽  
T. Clausen
Keyword(s):  
Thyroid Hormone ◽  
Soleus Muscle ◽  
Initial Rate ◽  
Muscle Endurance ◽  
Na Channels ◽  
Progressive Loss ◽  
Rat Soleus Muscle

We have previously observed in rat soleus muscle that endurance is a function of the ratio between the concentration of Na+ channels and Na+-K+pumps [Harrison, A. P., O. B. Nielsen, and T. Clausen. Am. J. Physiol. 272 ( Regulatory Integrative Comp. Physiol.41): R1402–R1408, 1997]. In this study we explore this relationship further by comparing the changes in Na+ channel and Na+-K+pump concentrations induced by injections of 3,5,3′-triiodothyronine (T3) with endurance. T3 induced upregulation of the concentration of Na+ channels and Na+-K+pumps, which was associated with a progressive loss of contractile endurance. The increase in Na+channels preceded that of the Na+-K+pumps and amounted to 49 and 52% (both P < 0.01) after 48 and 72 h of T3 treatment, respectively. Concomitantly, during 90-Hz stimulation, the initial rate of force decline increased by 42 and 45% after 48 and 72 h of T3 treatment, respectively (both P < 0.001). These observations are important for an understanding of the fatigue associated with hyperthyroidism and add further support to the hypothesis that muscle endurance depends on the leak-to-pump ratio for Na+.

scholarly journals Actions of perchlorate ions on rat soleus muscle fibres.

1992 ◽  
Vol 448 (1) ◽  
pp. 99-119 ◽  
Author(s):  
A F Dulhunty ◽  
P H Zhu ◽  
M F Patterson ◽  
G Ahern
Keyword(s):  
Soleus Muscle ◽  
Muscle Fibres ◽  
Rat Soleus Muscle
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