Luminal transport step of para -aminohippurate (PAH): transport from PAH-loaded proximal tubular cells into the tubular lumen of the rat kidney in vivo

1997 ◽  
Vol 433 (6) ◽  
pp. 735-743 ◽  
Author(s):  
K. J. Ullrich ◽  
Gerhard Rumrich
Keyword(s):  
Rat Kidney ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Tubular Lumen ◽  
Proximal Tubular

Inhibition by insulin of cellular autophagy in proximal tubular cells of rat kidney

1983 ◽  
Vol 244 (2) ◽  
pp. E109-E114 ◽  
Author(s):  
U. Pfeifer ◽  
M. Warmuth-Metz
Keyword(s):  
Volume Fraction ◽  
Rat Kidney ◽  
Insulin Dose ◽  
Ringer Solution ◽  
Numerical Density ◽  
Partial Recovery ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Cellular Autophagy ◽  
Proximal Tubular

Adult male Sprague-Dawley rats were injected intraperitoneally with 5 U insulin/kg body wt (45 animals). As determined by quantitative electron microscopy, the volume fraction and the numerical density of autophagic vacuoles (AV) in proximal tubular cells decreased within 10 min by 46 and 26%, respectively. A partial recovery of the AV volume fraction was observed 20 and 30 min after the injection contrary to our previous findings with liver (J. Cell Biol. 78: 152-167, 1978). In an additional experiment (12 animals) it was shown that an insulin dose of 0.5 U but not of 0.05 U/kg body wt reduced the AV volume fraction to an extent similar to that of 5 U. To eliminate possible secondary effects, Ringer solution containing 0.8 microM insulin was dropped intravitally for 15 min to one pole of the decapsulated kidney and Ringer solution without additions to the other pole (8 animals). After intravital fixation, the AV volume fraction and numerical density in proximal tubular cells was found to be reduced under the influence of insulin by 22 and 36%, respectively. This data shows that insulin inhibits the process of cellular autophagy in proximal tubular cells of the kidney.

scholarly journals The effect of proteinuria-mediated endothelin-1 downregulation of PKCα signalling in proximal tubular cells and its successful/INS; treatment is measurable using microRNA15a as biomarker in vitro and in vivo

Life Sciences ◽  
2013 ◽  
Vol 93 (25-26) ◽  
pp. e5-e6
Author(s):  
Heike Loeser ◽  
Melanie von Brandenstein ◽  
Maike Wittersheim ◽  
Volker Burst ◽  
Claudia Richter ◽  
...  
Keyword(s):  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Endothelin 1 ◽  
Proximal Tubular

Autoradiographical studies on the localization of metallothionein in proximal tubular cells of the rat kidney

1983 ◽  
Vol 53 (3) ◽  
pp. 185-192 ◽  
Author(s):  
M. Murakami ◽  
C. Tohyama ◽  
K. Sano ◽  
R. Kawamura ◽  
K. Kubota
Keyword(s):  
Rat Kidney ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Proximal Tubular

Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney

1989 ◽  
Vol 38 (21) ◽  
pp. 3731-3741 ◽  
Author(s):  
Pieter J. Boogaard ◽  
Jan N.M. Commandeur ◽  
Gerard J. Mulder ◽  
Nico P.E. Vermeulen ◽  
J.Fred Nagelkerke
Keyword(s):  
Rat Kidney ◽  
Mercapturic Acids ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Proximal Tubular
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