RISC (Repolarization-induced stop of caffeine-contracture) is not due to store depletion in cultured murine skeletal muscle

1996 ◽  
Vol 432 (5) ◽  
pp. 948-951 ◽  
Author(s):  
N. Suda ◽  
C. Heinemann
Keyword(s):  
Skeletal Muscle ◽  
Caffeine Contracture ◽  
Store Depletion ◽  
Murine Skeletal Muscle

scholarly journals Migration of dendritic cells from murine skeletal muscle

Immunobiology ◽  
2011 ◽  
Vol 216 (1-2) ◽  
pp. 195-199 ◽  
Author(s):  
Lei Wang ◽  
Saman Eghtesad ◽  
Paula R. Clemens
Keyword(s):  
Skeletal Muscle ◽  
Dendritic Cells ◽  
Murine Skeletal Muscle

Caffeine treatment inhibits drug-induced calcium release from sarcoplasmic reticulum and caffeine contracture but not tetanus in frog skeletal muscle

1989 ◽  
Vol 67 (8) ◽  
pp. 890-895 ◽  
Author(s):  
Makoto Koshita ◽  
Toshiharu Oba
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Calcium Release ◽  
Electrical Stimulus ◽  
Final Concentration ◽  
Heavy Fraction ◽  
Frog Skeletal Muscle ◽  
Drug Induced ◽  
Physiological Signal ◽  
Caffeine Contracture

Effects of pretreatment with caffeine on Ca2+ release induced by caffeine, thymol, quercetin, or p-chloromercuriphenylsulfonic acid (pCMPS) from the heavy fraction of sarcoplasmic reticulum (SR) were studied and compared with those effects on caffeine contracture and tetanus tension in single fibers of frog skeletal muscle. Caffeine (1–5 mM) did induce transient Ca2+ release from SR vesicles, but subsequent further addition of caffeine (10 mM, final concentration) induced little Ca2+ release. Ca2+ release induced by thymol, quercetin, or pCMPS was also inhibited by pretreatment with caffeine. In single muscle fibers, pretreatment with caffeine (1–5 mM) partially reduced the contracture induced by 10 mM caffeine. However, tetanus tension was almost maximally induced by electrical stimulus in caffeine-treated fibers. These results indicate that SR, which becomes less sensitive to caffeine, thymol, quercetin, or pCMPS by pretreatment with caffeine, can still respond to a physiological signal transmitted from transverse tubules.Key words: Ca2+ release, sarcoplasmic reticulum, caffeine, tetanus, skeletal muscle.

scholarly journals Doxorubicin stimulates oxidant activity, weakness and fatigue in murine skeletal muscle

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Laura A. Ashley ◽  
Leonardo F. Ferreira ◽  
Jeff D. Smith ◽  
Brian J. Hardin ◽  
Teresa J. Noel ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Murine Skeletal Muscle

Isolation of a slowly adhering cell fraction containing stem cells from murine skeletal muscle by the preplate technique

2008 ◽  
Vol 3 (9) ◽  
pp. 1501-1509 ◽  
Author(s):  
Burhan Gharaibeh ◽  
Aiping Lu ◽  
Jessica Tebbets ◽  
Bo Zheng ◽  
Joe Feduska ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Cell Fraction ◽  
Murine Skeletal Muscle

scholarly journals Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle

2020 ◽  
Vol 117 (10) ◽  
pp. 5402-5408 ◽  
Author(s):  
Kathy Wang ◽  
Omar K. Yaghi ◽  
Raul German Spallanzani ◽  
Xin Chen ◽  
David Zemmour ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Immune Cell ◽  
Treg Cells ◽  
T Regulatory Cell ◽  
Calcitonin Gene ◽  
Genes Encoding ◽  
Large Fiber ◽  
Murine Skeletal Muscle ◽  
Related Proteins ◽  
Cell Crosstalk

A distinct population of Foxp3+CD4+ regulatory T (Treg) cells promotes repair of acutely or chronically injured skeletal muscle. The accumulation of these cells depends critically on interleukin (IL)-33 produced by local mesenchymal stromal cells (mSCs). An intriguing physical association among muscle nerves, IL-33+ mSCs, and Tregs has been reported, and invites a deeper exploration of this cell triumvirate. Here we evidence a striking proximity between IL-33+ muscle mSCs and both large-fiber nerve bundles and small-fiber sensory neurons; report that muscle mSCs transcribe an array of genes encoding neuropeptides, neuropeptide receptors, and other nerve-related proteins; define muscle mSC subtypes that express both IL-33 and the receptor for the calcitonin-gene–related peptide (CGRP); and demonstrate that up- or down-tuning of CGRP signals augments or diminishes, respectively, IL-33 production by muscle mSCs and later accumulation of muscle Tregs. Indeed, a single injection of CGRP induced much of the genetic program elicited in mSCs early after acute skeletal muscle injury. These findings highlight neural/stromal/immune-cell crosstalk in tissue repair, suggesting future therapeutic approaches.

scholarly journals Effects of fasting on isolated murine skeletal muscle contractile function during acute hypoxia

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0225922
Author(s):  
Cameron A. Schmidt ◽  
Emma J. Goldberg ◽  
Tom D. Green ◽  
Reema R. Karnekar ◽  
Jeffrey J. Brault ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Contractile Function ◽  
Acute Hypoxia ◽  
Murine Skeletal Muscle ◽  
Muscle Contractile

scholarly journals Mild Hypobaric Hypoxia Effects on Murine Skeletal Muscle Morphology and Macrophages and Well-Being

2019 ◽  
Vol 90 (12) ◽  
pp. 1050-1054 ◽  
Author(s):  
Liyuan Zhang ◽  
Julia Soulakova ◽  
Barbara St. Pierre Schneider
Keyword(s):  
Skeletal Muscle ◽  
Hypobaric Hypoxia ◽  
Well Being ◽  
Primary Objective ◽  
Medial Gastrocnemius ◽  
Muscle Morphology ◽  
Cellular Effects ◽  
Hindlimb Muscles ◽  
Murine Skeletal Muscle ◽  
Macrophage Populations

BACKGROUND: In the last 10 yr, the number of ultra-haul flights—defined as flights greater than 12 h of flying time—has increased. While the medical complications of these flights are well-known, the underlying cellular effects are less clear. The primary objective of this study was to test the effects of extended mild hypobaric hypoxia on overall well-being and skeletal muscle morphology and macrophage populations.METHODS: A total of 22 male C57BL/6 mice were assigned to a normobaric (NB) or hypobaric (HB) chamber for 14–17 h. Overall mouse well-being and the general morphology and resident macrophage number in hindlimb muscles were compared between the two pressure conditions.RESULTS: During mild hypobaric hypoxia, the mice behaved normally and no changes were observed in general muscle morphology. Regarding resident macrophages, the mean antigen area of CD206 in the hindlimb muscles, lateral gastrocnemius (LG, 33.8 ± 2.0 vs. 35.3 ± 1.6), medial gastrocnemius (MG, 32.4 ± 1.6 vs. 32.6 ± 1.5), and quadriceps femoris (QF, 36.3 ± 1.2 vs. 34.3 ± 1.1) were similar between NB and HB conditions, and the number of CD68-positive cells in the LG and QF were similar between the two conditions. Significantly fewer CD206-positive cells were counted in the LG muscle under the HB condition.CONCLUSION: Our findings indicate that extended exposure to mild hypobaric hypoxia, similar to that of an ultra-long-haul flight, does not adversely affect healthy skeletal muscle.Zhang L, Soulakova J, St. Pierre Schneider B. Mild hypobaric hypoxia effects on murine skeletal muscle morphology and macrophages and well-being. Aerosp Med Hum Perform. 2019; 90(12):1050–1054.

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