The effects of caldesmon extraction on mechanical properties of skinned smooth muscle fibre preparations

1996 ◽  
Vol 432 (2) ◽  
pp. 241-247 ◽  
Author(s):  
Ulf Malmqvist ◽  
Anders Arner ◽  
Robert Makuch ◽  
Renata Dabrowska
Keyword(s):  
Mechanical Properties ◽  
Smooth Muscle ◽  
Muscle Fibre ◽  
Skinned Smooth Muscle ◽  
Smooth Muscle Fibre

scholarly journals Effects of 1,8-cineole (eucalyptol) on the activity of human bronchial tissue

2019 ◽  
pp. 12-22
Author(s):  
André-Michael Beer ◽  
Plamen Sagorchev ◽  
Julian Lukanov
Keyword(s):  
Smooth Muscle ◽  
Muscle Fibre ◽  
Contractile Activity ◽  
Histamine Receptors ◽  
Human Airway Smooth Muscle ◽  
Bronchial Smooth Muscle ◽  
Airway Diseases ◽  
Smooth Muscle Fibre ◽  
Bronchial Tissue ◽  
Treatment Use

1,8-cineole (eucalyptol) is used for the treatment of bronchial complaints, sinusitis and colds. Experiments have previously shown that 1,8-cineole, a monoterpene (C-10), has a very pronounced spasmolytic effect on smooth muscle fibre. In nearly all clinical applications with 1,8-cineole, especially when used in conjunction with allergic symptoms, histamine receptors prove to be crucial for treatment (use of histamine inhibitors). Results: The desired 1,8-cineole effects are attained through: specifically blocking H1 histamine receptors, without influencing ACh receptors Inhibiting the contractile activity of human bronchial smooth muscle by activating H2 histamine receptors. The ultimate goal of this study was to address the bronchodilatory effect of this compound, using human airway smooth muscle in order to demonstrate a possible role for 1,8-cineole in airway diseases. Keywords: Smooth muscle fibre; 1,8-cineole (eucalyptol); Human bronchial tissue; Bronchitis; Monoterpene

Regulation of Ca2+ sensitivity in alpha-toxin skinned smooth muscle

1992 ◽  
Vol 24 ◽  
pp. 36
Author(s):  
Cornelis van Breemen ◽  
Junji Nishimura ◽  
Suzanne Moreland ◽  
Robert S. Moreland
Keyword(s):  
Smooth Muscle ◽  
Alpha Toxin ◽  
Skinned Smooth Muscle

Mechanical properties of human bronchial smooth muscle in vitro

1992 ◽  
Vol 73 (4) ◽  
pp. 1481-1485 ◽  
Author(s):  
K. Ishida ◽  
P. D. Pare ◽  
J. Hards ◽  
R. R. Schellenberg
Keyword(s):  
Mechanical Properties ◽  
Smooth Muscle ◽  
Electrical Field Stimulation ◽  
Tracheal Smooth Muscle ◽  
Cross Sectional ◽  
Velocity Of Shortening ◽  
Muscle Shortening ◽  
Tension Generation ◽  
Very High

The in vitro mechanical properties of smooth muscle strips from 10 human main stem bronchi obtained immediately after pneumonectomy were evaluated. Maximal active isometric and isotonic responses were obtained at varying lengths by use of electrical field stimulation (EFS). At the length (Lmax) producing maximal force (Pmax), resting tension was very high (60.0 +/- 8.8% Pmax). Maximal fractional muscle shortening was 25.0 +/- 9.0% at a length of 75% Lmax, whereas less shortening occurred at Lmax (12.2 +/- 2.7%). The addition of increasing elastic loads produced an exponential decrease in the shortening and velocity of shortening but increased tension generation of muscle strips stimulated by EFS. Morphometric analysis revealed that muscle accounted for 8.7 +/- 1.5% of the total cross-sectional tissue area. Evaluation of two human tracheal smooth muscle preparations revealed mechanics similar to the bronchial preparations. Passive tension at Lmax was 10-fold greater and maximal active shortening was threefold less than that previously demonstrated for porcine trachealis by us of the same apparatus. We attribute the limited shortening of human bronchial and tracheal smooth muscle to the larger load presumably provided by a connective tissue parallel elastic component within the evaluated tissues, which must be overcome for shortening to occur. We suggest that a decrease in airway wall elastance could increase smooth muscle shortening, leading to excessive responses to contractile agonists, as seen in airway hyperresponsiveness.

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