Protein kinase C suppresses spontaneous, transient, outwards K + currents through modulation of the Na/Ca exchanger in guinea-pig gastric myocytes

2001 ◽  
Vol 441 (4) ◽  
pp. 417-424 ◽  
Author(s):  
Seung Cheol Ahn ◽  
Sang Jin Lee ◽  
Jae Hoon Sim ◽  
Insuk So ◽  
Ki Whan Kim ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Kinase C ◽  
Gastric Myocytes ◽  
K Currents

Protein kinase C mediates the desensitization of CCh-activated nonselective cationic current in guinea-pig gastric myocytes

1998 ◽  
Vol 436 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Young Chul Kim ◽  
Sung Joon Kim ◽  
Jae Hoon Sim ◽  
Jae Yeoul Jun ◽  
Tong Mook Kang ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Cationic Current ◽  
Kinase C ◽  
Gastric Myocytes ◽  
Nonselective Cationic Current

scholarly journals K+ currents expressed from the guinea pig cardiac IsK protein are enhanced by activators of protein kinase C.

1994 ◽  
Vol 91 (5) ◽  
pp. 1766-1770 ◽  
Author(s):  
Z. J. Zhang ◽  
N. K. Jurkiewicz ◽  
K. Folander ◽  
E. Lazarides ◽  
J. J. Salata ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Kinase C ◽  
K Currents

Protein Kinase C-Dependent Inhibition of K+ Currents in Noradrenaline-Induced Depolarization of Smooth Muscle of Guinea-Pig vas Deferens

2000 ◽  
Vol 85 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Noritaka Kamimura ◽  
Sechiko Suga ◽  
Kyoko Nakano ◽  
Takahiro Kanno ◽  
Teruko Takeo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Vas Deferens ◽  
Kinase C ◽  
Dependent Inhibition ◽  
K Currents

scholarly journals NMDA Induces Protein Kinase C Translocation in Guinea Pig Cerebral Synaptoneurosomes.

1991 ◽  
Vol 56 (3) ◽  
pp. 287-296 ◽  
Author(s):  
Susumu Etoh ◽  
Akemichi Baba ◽  
Heitaroh Iwata
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Kinase C

Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle

1993 ◽  
Vol 265 (6) ◽  
pp. C1723-C1728 ◽  
Author(s):  
A. D. Bonev ◽  
M. T. Nelson
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Urinary Bladder ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Katp Channels ◽  
Muscle Cells ◽  
Receptor Stimulation ◽  
Kinase C

We explored the possibility that muscarinic receptor stimulation can inhibit ATP-sensitive K+ (KATP) channels in smooth muscle cells from guinea pig urinary bladder. Whole cell K+ currents were measured in smooth muscle cells isolated from the detrusor muscle of the guinea pig bladder. Stimulation of muscarinic receptors by carbachol (CCh; 10 microM) inhibited KATP currents by 60.7%. Guanosine 5'-O-(2-thiodiphosphate) in the pipette (internal) solution prevented the CCh-induced inhibition of KATP currents. Activators of protein kinase C (PKC), a diacylglycerol analogue, and phorbol 12-myristate 13-acetate inhibited KATP currents by 63.5 and 73.9%, respectively. Blockers of PKC (bisindolylmaleimide GF-109203X and calphostin C) greatly reduced CCh inhibition of KATP currents. We propose that muscarinic receptor stimulation inhibits KATP channels in smooth muscle cells from urinary bladder through activation of PKC.

Modulation of Two K+ Currents by Inositol Trisphosphate and Protein Kinase C

1989 ◽  
pp. 117-128
Author(s):  
Haruhiro Higashida ◽  
David. A. Brown ◽  
Akihiko Ogura ◽  
Junji Sagara ◽  
Kazuhiro Nagata
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Inositol Trisphosphate ◽  
Kinase C ◽  
K Currents

Role of Protein Kinase C in Duodenal Mucosal Bicarbonate Secretion in the Guinea Pig

Pharmacology ◽  
1996 ◽  
Vol 53 (1) ◽  
pp. 60-65 ◽  
Author(s):  
H.S. Odes ◽  
R. Reimer ◽  
R. Muallem ◽  
M. Schwenk ◽  
W. Beil ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Bicarbonate Secretion ◽  
Kinase C

scholarly journals NMDA Induces Protein Kinase C Translocation in Guinea Pig Cerebral Synaptoneurosomes

1991 ◽  
Vol 56 (3) ◽  
pp. 287-296
Author(s):  
Susumu Etoh ◽  
Akemichi Baba ◽  
Heitaroh lwata
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Kinase C

scholarly journals Involvement of protein kinase C in the relaxation of acetylcholine-shortened isolated intact smooth muscle cells from the guinea-pig stomach

1995 ◽  
Vol 67 ◽  
pp. 206
Author(s):  
Sanae Nakamura ◽  
Tsuyoshi Isliibashi ◽  
Mitsuo Mita ◽  
Takao Hashimoto ◽  
Kazuhiko Oishi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Kinase C ◽  
Guinea Pig Stomach
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