Internalization kinetics of the gonadotropin-releasing hormone (GnRH) receptor

2000 ◽  
Vol 439 (S1) ◽  
pp. r019-r020 ◽  
Author(s):  
Milka Vrecl ◽  
Anders Heding ◽  
Aylin Hanyaloglu ◽  
Philip L. Taylor ◽  
Karin A. Eidne
Keyword(s):  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Internalization Kinetics ◽  
Kinetics Of

Internalization kinetics of the gonadotropin-releasing hormone (GnRH) receptor

2000 ◽  
Vol 439 (7) ◽  
pp. R19-R20
Author(s):  
Milka Vrecl ◽  
Anders Heding ◽  
Aylin Hanyaloglu ◽  
Philip L. Taylor ◽  
Karin A. Eidne
Keyword(s):  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Internalization Kinetics ◽  
Kinetics Of

scholarly journals Contrasting internalization kinetics of human and chicken gonadotropin-releasing hormone receptors mediated by C-terminal tail

1998 ◽  
Vol 156 (3) ◽  
pp. R9-12 ◽  
Author(s):  
AJ Pawson ◽  
A Katz ◽  
YM Sun ◽  
J Lopes ◽  
N Illing ◽  
...  
Keyword(s):  
Gnrh Agonist ◽  
Hormone Receptors ◽  
Cytoplasmic Tail ◽  
Gonadotropin Releasing Hormone ◽  
Receptor Internalization ◽  
Wild Type ◽  
Releasing Hormone ◽  
In The Wild ◽  
Internalization Kinetics ◽  
Kinetics Of

The chicken gonadotropin-releasing hormone receptor (GnRH-R) is notable for having a cytoplasmic C-terminal tail, which is not present in the mammalian GnRH-Rs. We report here that the cytoplasmic tail mediates rapid agonist-promoted receptor internalization. The chicken GnRH-R mediated internalization of gonadotropin-releasing hormone (GnRH) agonist (125I[His5-D-Tyr6]GnRH) at a rate of 11.3%.min-1, compared with only 0.71 %.min-1 for the human GnRH-R. To determine whether the presence of the cytoplasmic tail was responsible for the more rapid internalization kinetics of the chicken GnRH-R we truncated the tail after the Ile336 residue (S337stop). Receptor-mediated internalization of GnRH agonist by the S337stop-chicken GnRH-R was much slower than in the wild-type chicken receptor, and was similar to the wild-type human GnRH-R (0.55 %.min-1). These data indicate that rapid agonist-promoted internalization of the chicken GnRH-R is mediated through elements in the cytoplasmic C-terminal tail, distal to or including Ser337 and suggests that elimination of the C-terminal tail during evolution of mammalian GnRH-Rs may be related to its effects on internalization.

scholarly journals Identification of Ser153in ICL2 of the Gonadotropin-releasing Hormone (GnRH) Receptor as a Phosphorylation-independent Site for Inhibition of GqCoupling

2005 ◽  
Vol 280 (32) ◽  
pp. 28981-28988 ◽  
Author(s):  
Sharon Shacham ◽  
Maya N. Cheifetz ◽  
Mati Fridkin ◽  
Adam J. Pawson ◽  
Robert P. Millar ◽  
...  
Keyword(s):  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Independent Site

Chitosan-based DNA delivery vector targeted to gonadotropin-releasing hormone (GnRH) receptor

2017 ◽  
Vol 157 ◽  
pp. 311-320 ◽  
Author(s):  
Chatwalee Boonthum ◽  
Katawut Namdee ◽  
Suwimon Boonrungsiman ◽  
Kaywalee Chatdarong ◽  
Nattika Saengkrit ◽  
...  
Keyword(s):  
Dna Delivery ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Delivery Vector
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