Prospective randomised trial on adjuvant hepatic-artery infusion chemotherapy after R0 resection of colorectal liver metastases

1999 ◽  
Vol 384 (3) ◽  
pp. 243-249 ◽  
Author(s):  
C. Rudroff ◽  
A. Altendorf-Hoffmann ◽  
R. Stangl ◽  
J. Scheele
Keyword(s):  
Liver Metastases ◽  
Hepatic Artery ◽  
Colorectal Liver Metastases ◽  
Randomised Trial ◽  
R0 Resection ◽  
Hepatic Artery Infusion ◽  
Infusion Chemotherapy ◽  
Prospective Randomised Trial ◽  
Hepatic Artery Infusion Chemotherapy

scholarly journals Modern Prospection for Hepatic Arterial Infusion Chemotherapy in Malignancies with Liver Metastases

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Yi-Hsin Liang ◽  
Yu-Yun Shao ◽  
Jia-Yi Chen ◽  
Po-Chin Liang ◽  
Ann-Lii Cheng ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Hepatic Artery ◽  
Liver Tumors ◽  
Hepatic Artery Infusion ◽  
Special Focus ◽  
Infusion Chemotherapy ◽  
Study Results ◽  
Hepatic Artery Infusion Chemotherapy ◽  
Metastatic Liver Tumors ◽  
Metastatic Liver

Malignancy with liver metastasis plays an important role in daily oncology practice, especially for primary cancers of the gastrointestinal tract and hepatopancreatobiliary system. On account of the dual vascular supply system and the fact that most metastatic liver tumors are supplied by the hepatic artery, hepatic artery infusion chemotherapy (HAIC) is an appealing method for the treatment of liver metastases. Herein, we summarize recent study results reported in the literature regarding the use of HAIC for metastatic liver tumors, with special focus on colorectal cancer.

Association of adjuvant hepatic artery infusion chemotherapy after resection of colorectal liver metastases with improved survival in patients with both right- and left-sided primary tumors.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 776-776
Author(s):  
Sepideh Gholami ◽  
Nancy E. Kemeny ◽  
Mithat Gonen ◽  
Andrea Cercek ◽  
Peter Kingham ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Hepatic Artery ◽  
Primary Tumor ◽  
Colorectal Liver Metastases ◽  
Hepatic Artery Infusion ◽  
Primary Tumor Site ◽  
Primary Tumors ◽  
Kras Status ◽  
Hepatic Artery Infusion Chemotherapy ◽  
The Impact

776 Background: Patients with a right-sided (R) and/or KRAS-mutated (KRAS-MUT) primary tumors have inferior outcomes compared to patients with left sided (L) and/or KRAS-wildtype (KRAS-WT) cancers. Adjuvant hepatic artery pump infusion (HAI) chemotherapy improves overall survival (OS) in patients with colorectal liver metastases (CRLM). We investigated the impact of HAI in relation to the laterality and KRAS status of the primary tumors. Methods: Patients with resected CRLM and available KRAS-status, treated with and without adjuvant HAI were reviewed from a prospective institutional database. Rectal tumors were excluded. Correlations between adjuvant HAI, clinicopathological factors including laterality, KRAS status and OS were analyzed. Cox proportional hazard regression was used to assess survival outcomes comparing R (cecum to transverse colon, excluding appendix) versus L (splenic flexure to sigmoid) colon cancers. Results: 490 patients (R, n = 183; L, n = 307) were evaluated between 1993-2012 (median follow up of 6.5 years). Fifty-six percent (n = 277) received adjuvant HAI. Adjuvant HAI was associated with improved median OS in both R (7.0 vs. 4.4 years, p = 0.006) and L tumors (10.5 vs. 5.4 years, p < 0.01). On multivariate analysis, HAI remained associated with improved OS (HR 4.49, p = 0.001) independent of primary tumor site and other clinical predictors (Table). Conclusions: Adjuvant HAI after resection of CRLM is independently associated with improved OS regardless of laterality of primary tumor. Treatment with adjuvant HAI correlates with improved prognosis in patients with resectable L/KRAS-MUT and R/KRAS-WT tumors. The biological difference for these outcomes requires further investigation. [Table: see text]

scholarly journals Adjuvant hepatic artery infusion chemotherapy after hemihepatectomy for gastric cancer liver metastases

2017 ◽  
Vol 46 ◽  
pp. 79-84 ◽  
Author(s):  
Yasuyuki Fukami ◽  
Yuji Kaneoka ◽  
Atsuyuki Maeda ◽  
Yuichi Takayama ◽  
Takamasa Takahashi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastases ◽  
Hepatic Artery ◽  
Hepatic Artery Infusion ◽  
Infusion Chemotherapy ◽  
Hepatic Artery Infusion Chemotherapy

Causes of jaundice during hepatic artery infusion chemotherapy.

Radiology ◽  
1986 ◽  
Vol 161 (2) ◽  
pp. 439-442 ◽  
Author(s):  
S D Anderson ◽  
H C Holley ◽  
L L Berland ◽  
J A Van Dyke ◽  
R J Stanley
Keyword(s):  
Hepatic Artery ◽  
Hepatic Artery Infusion ◽  
Infusion Chemotherapy ◽  
Hepatic Artery Infusion Chemotherapy

Fatty Liver Change as a Result of Hepatic Artery Infusion Chemotherapy

1990 ◽  
Vol 13 (2) ◽  
pp. 156-160 ◽  
Author(s):  
Jacob Zeiss ◽  
Hollis W. Merrick ◽  
Edward R. Savolaine ◽  
Lee S. Woldenberg ◽  
Kitai Kim ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Hepatic Artery ◽  
Hepatic Artery Infusion ◽  
Infusion Chemotherapy ◽  
Liver Change ◽  
Hepatic Artery Infusion Chemotherapy
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