Adaptations in rat skeletal muscle following long-term resistance exercise training

1998 ◽  
Vol 77 (4) ◽  
pp. 372-378 ◽  
Author(s):  
Noel D. Duncan ◽  
David A. Williams ◽  
Gordon S. Lynch
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Rat Skeletal Muscle ◽  
Resistance Exercise Training

scholarly journals Consecutive bouts of electrical stimulation-induced contractions alter ribosome biogenesis in rat skeletal muscle

2019 ◽  
Vol 126 (6) ◽  
pp. 1673-1680
Author(s):  
Takaya Kotani ◽  
Junya Takegaki ◽  
Ryo Takagi ◽  
Koichi Nakazato ◽  
Naokata Ishii
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Cyclin D1 ◽  
Ribosome Biogenesis ◽  
28S Rrna ◽  
Rat Skeletal Muscle ◽  
Resistance Exercise Training ◽  
Muscle Weight ◽  
Skeletal Muscle Hypertrophy

Ribosome biogenesis has been implicated in resistance exercise training (RET)-induced skeletal muscle hypertrophy. However, it is unclear how increasing bouts of RET affects ribosome content and biogenesis. This was investigated in the present study using simulated RET where rat skeletal muscle is subjected to increasing bouts of electrical stimulation. Sprague-Dawley rats were randomly assigned to the following seven groups: sedentary for 5 days (SED) or 6 wk (SED_6w), resistance-exercise trained with 1 bout (1B), 2 bouts (2B), 3 bouts (3B), 6 bouts (6B), and 18 bouts (18B). RET was simulated on the right gastrocnemius muscle by transcutaneous electric stimulation under isoflurane anesthesia, and a RET bout was given 3 times a week. Rats in 1B, 2B, and 3B groups showed increased 45S precursor (pre-) rRNA and 18S+28S rRNA content per muscle weight and elevated mRNA levels of c- myc and upstream binding factor (UBF). Increases in phosphorylated UBF and total cyclin D1 protein level were observed 48 h after RET; the former increased as a function of RET duration. In 3B, 6B, and 18B groups, the 18S+28S rRNA content per muscle weight was kept unchanged, and 45S pre-rRNA, cyclin D1, and phosphorylated UBF levels in 18B were lower than those in 3B. These results suggest that RET activates ribosome biogenesis and increases ribosome content through modulation of UBF and cyclin D1 activity at its early phase. Additional bouts of RET may not lead to a further increase in ribosome content per muscle weight through possibly the attenuation of transcription process. NEW & NOTEWORTHY Ribosome biogenesis has been implicated in resistance exercise training-induced skeletal muscle hypertrophy. However, it remains unclear how this is influenced by the volume of repeated bouts of resistance exercise training. Using resistance exercise training model with rat skeletal muscle, we provide evidence that ribosome biogenesis is stimulated by the initial few bouts of resistance exercise training with no additional effect of further increase in the exercise bout.

scholarly journals Aerobic and resistance exercise training reverses age‐dependent decline in NAD + salvage capacity in human skeletal muscle

2019 ◽  
Vol 7 (12) ◽  
Author(s):  
Roldan M. de Guia ◽  
Marianne Agerholm ◽  
Thomas S. Nielsen ◽  
Leslie A. Consitt ◽  
Ditte Søgaard ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Resistance Exercise Training ◽  
Age Dependent

scholarly journals Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

2015 ◽  
Vol 47 (9) ◽  
pp. 1922-1931 ◽  
Author(s):  
CRAIG PORTER ◽  
PAUL T. REIDY ◽  
NISHA BHATTARAI ◽  
LABROS S. SIDOSSIS ◽  
BLAKE B. RASMUSSEN
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle ◽  
Resistance Exercise Training
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