Comparison of 13 published cytochrome c oxidase near-infrared spectroscopy algorithms

1996 ◽  
Vol 74 (6) ◽  
pp. 487-495 ◽  
Author(s):  
R. E. Gagnon ◽  
Faith A. Gagnon ◽  
Andrew J. Macnab
Keyword(s):  
Infrared Spectroscopy ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared Spectroscopy ◽  
Near Infrared

scholarly journals Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data

2017 ◽  
Vol 4 (2) ◽  
pp. 021105 ◽  
Author(s):  
Sabrina Brigadoi ◽  
Phong Phan ◽  
David Highton ◽  
Samuel Powell ◽  
Robert J. Cooper ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Image Reconstruction ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Spectroscopy Data

Cytochrome-c-oxidase redox changes during visual stimulation measured by near-infrared spectroscopy cannot be explained by a mere cross talk artefact

NeuroImage ◽  
2004 ◽  
Vol 22 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Kâmil Uludağ ◽  
Jens Steinbrink ◽  
Matthias Kohl-Bareis ◽  
Rüdiger Wenzel ◽  
Arno Villringer ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared Spectroscopy ◽  
Cross Talk ◽  
Near Infrared ◽  
Visual Stimulation

scholarly journals Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: A broadband near-infrared spectroscopy study

2017 ◽  
Vol 37 (12) ◽  
pp. 3789-3802 ◽  
Author(s):  
Xinlong Wang ◽  
Fenghua Tian ◽  
Divya D Reddy ◽  
Sahil S Nalawade ◽  
Douglas W Barrett ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared Spectroscopy ◽  
Time Course ◽  
Near Infrared ◽  
Cerebral Metabolism ◽  
Infrared Laser ◽  
Cortical Region ◽  
Laser Stimulation

Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular photoacceptor. We hypothesized that TILS up-regulates cerebral CCO and causes hemodynamic changes. We delivered 1064-nm laser stimulation to the forehead of healthy participants ( n = 11), while broadband near-infrared spectroscopy was utilized to acquire light reflectance from the TILS-treated cortical region before, during, and after TILS. Placebo experiments were also performed for accurate comparison. Time course of spectroscopic readings were analyzed and fitted to the modified Beer–Lambert law. With respect to the placebo readings, we observed (1) significant increases in cerebral concentrations of oxidized CCO (Δ[CCO]; >0.08 µM; p < 0.01), oxygenated hemoglobin (Δ[HbO]; >0.8 µM; p < 0.01), and total hemoglobin (Δ[HbT]; >0.5 µM; p < 0.01) during and after TILS, and (2) linear interplays between Δ[CCO] versus Δ[HbO] and between Δ[CCO] versus Δ[HbT]. Ratios of Δ[CCO]/Δ[HbO] and Δ[CCO]/Δ[HbT] were introduced as TILS-induced metabolic-hemodynamic coupling indices to quantify the coupling strength between TILS-enhanced cerebral metabolism and blood oxygen supply. This study provides the first demonstration that TILS causes up-regulation of oxidized CCO in the human brain, and contributes important insight into the physiological mechanisms.

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