Expression of connexin 37, 40, and 43 mRNA and protein in renal preglomerular arterioles

2001 ◽  
Vol 115 (6) ◽  
pp. 479-487 ◽  
Author(s):  
Birgitte Arensbak ◽  
Hanne B. Mikkelsen ◽  
Finn Gustafsson ◽  
Thorkil Christensen ◽  
Niels-Henrik Holstein-Rathlou
Keyword(s):  
Connexin 37 ◽  
Preglomerular Arterioles

scholarly journals Connections in chronic kidney disease: connexin 43 and connexin 37 interaction

2011 ◽  
Vol 301 (1) ◽  
pp. F21-F23 ◽  
Author(s):  
Pedro A. Jose ◽  
Shiyou Chen ◽  
Ines Armando
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Connexin 43 ◽  
Connexin 37

scholarly journals 20-HETE and the kidney: resolution of old problems and new beginnings

1999 ◽  
Vol 277 (3) ◽  
pp. R607-R623 ◽  
Author(s):  
John C. McGiff ◽  
John Quilley
Keyword(s):  
Thick Ascending Limb ◽  
Renal Circulation ◽  
Large Measure ◽  
Water Excretion ◽  
Renal Autoregulation ◽  
Blood Pressure Homeostasis ◽  
Calcium Activated Potassium Channels ◽  
New Beginnings ◽  
Cytochrome P 450 ◽  
Preglomerular Arterioles

The protean properties of 20-hydroxyeicosatetraenoic acid (HETE), vasoactivity, mitogenicity, and modulation of transport in key nephron segments, serve as the basis for the essential roles of 20-HETE in the regulation of the renal circulation and electrolyte excretion and as a second messenger for endothelin-1 and mediator of selective renal effects of ANG II. Renal autoregulation and tubular glomerular feedback are mediated by 20-HETE through constriction of preglomerular arterioles, responses that are maintained by 20-HETE inhibition of calcium-activated potassium channels. 20-HETE modulates ion transport in the proximal tubules and the thick ascending limb by affecting the activities of Na+-K+-ATPase and the Na+-K+-2Cl−cotransporter, respectively. The range and diversity of activity of 20-HETE derives in large measure from COX-dependent transformation of 20-HETE to products affecting vasomotion and salt and water excretion. Nitric oxide (NO) exerts a negative modulatory effect on 20-HETE formation; inhibition of NO synthesis produces marked perturbation of renal function resulting from increased 20-HETE production. 20-HETE is an essential component of interactions involving several hormonal systems that have central roles in blood pressure homeostasis, including angiotensins, endothelins, NO, and cytokines. 20-HETE is the preeminent renal eicosanoid, overshadowing PGE2 and PGI2. This review is intended to provide evidence for the physiological roles for cytochrome P-450-derived eicosanoids, particularly 20-HETE, and seeks to extend this knowledge to a conceptual framework for overall cardiovascular function.

Prostaglandins buffer ANG II-mediated increases in cytosolic calcium in preglomerular VSMC

1999 ◽  
Vol 277 (6) ◽  
pp. F850-F858 ◽  
Author(s):  
Kit E. Purdy ◽  
William J. Arendshorst
Keyword(s):  
Calcium Concentration ◽  
Cytosolic Calcium ◽  
Ang Ii ◽  
Vasoactive Factors ◽  
A Cell ◽  
Camp Levels ◽  
Dose Dependent ◽  
Peak Increase ◽  
Preglomerular Arterioles ◽  
Initial Peak

In order to exert an appropriate biological effect, the action of the vasoconstrictive hormone angiotensin II (ANG II) is modulated by vasoactive factors such as prostaglandins PGE2 and PGI2. The present study investigates whether prostaglandins alter ANG II-mediated increases in cytosolic calcium concentration ([Ca2+]i) in vascular smooth muscle cells (VSMC) isolated from rat renal preglomerular arterioles. [Ca2+]i was assessed using the calcium-sensitive dye fura 2 and a microscope-based photometer system. ANG II (10−7 M) caused a biphasic, time-dependent [Ca2+]i response: an initial peak increase from 52 ± 7 to 264 ± 25 nM, followed by a sustained plateau of 95 ± 9 nM in cultured VSMC. Coadministration of PGE2 or PGI2 or synthetic mimetics caused dose-dependent decreases in the peak [Ca2+]i response to ANG II, with attenuation of 40–50%. This degree of inhibition was even more pronounced in individual freshly isolated preglomerular VSMC. Increasing cAMP levels in cultured VSMC, by using either a cell-permeable analog or inhibiting phosphodiesterase activity, mirrored the antagonistic effects of prostaglandins on ANG II-stimulated increases in [Ca2+]i. Radioimmunoassays demonstrate that ANG II (10−7 M) stimulates production of PGI2 and PGE2; the stable prostacyclin metabolite 6-keto-PGF1 αwas released in 10-fold greater concentrations than PGE2.Indomethacin blockade of prostaglandin production potentiated both the peak (264 to 337 ± 26 nM) and sustained [Ca2+]i responses (95 to 181 ± 22 nM) to ANG II. When prostaglandin analogs were added during indomethacin treatment, the ANG II response was restored to the typical pattern. In conclusion, we demonstrate that modulation of intracellular calcium levels is one mechanism by which prostaglandins can buffer ANG II-mediated constriction in renal preglomerular VSMC. PGI2 is more potent than PGE2 in this regard.

Endothelial Connexin 37, Connexin 40, and Connexin 43 Respond Uniquely to Substrate and Shear Stress

Endothelium ◽  
2007 ◽  
Vol 14 (4-5) ◽  
pp. 215-226 ◽  
Author(s):  
Tiffany L. Johnson ◽  
Robert M. Nerem
Keyword(s):  
Shear Stress ◽  
Connexin 43 ◽  
Connexin 40 ◽  
Connexin 37

Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney

2009 ◽  
Vol 459 (1) ◽  
pp. 151-158 ◽  
Author(s):  
Charlotte Wagner ◽  
Lisa Kurtz ◽  
Frank Schweda ◽  
Alexander M. Simon ◽  
Armin Kurtz
Keyword(s):  
Connexin 37

Tu-P7: 156 Regulation of connexin 37 by oxidized phospholipids in atherosclerosis

2006 ◽  
Vol 7 (3) ◽  
pp. 219
Author(s):  
C.E. Culler ◽  
P.S. Gargalovic ◽  
T.G. Kirchgessner ◽  
A.J. Lusis
Keyword(s):  
Oxidized Phospholipids ◽  
Connexin 37

Mutations of the Connexin 37 and 40 Gap-Junction Genes in Patients with Acute Myocardial Infarction

2013 ◽  
Vol 59 (03+04/2013) ◽  
Author(s):  
Morteza Seifi ◽  
Soudabeh Fallah ◽  
Asghar Ghasemi ◽  
Hasan Aghajani ◽  
Maliheh Razaghi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Gap Junction ◽  
Connexin 37

scholarly journals Effects of small interfering RNA interference of connexin 37 on subcutaneous gastric tumours in mice

2014 ◽  
Vol 10 (6) ◽  
pp. 2955-2960 ◽  
Author(s):  
YUANMING JING ◽  
SUXIA GUO ◽  
XIAOPING ZHANG ◽  
AIJING SUN ◽  
FENG TAO ◽  
...  
Keyword(s):  
Rna Interference ◽  
Small Interfering Rna ◽  
Connexin 37 ◽  
Interfering Rna
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