Influence of fetal calf serum, fibroblast growth factors, and hepatocyte growth factor on three-dimensional cultures of human keratocytes in collagen gel matrix

1999 ◽  
Vol 237 (10) ◽  
pp. 861-869 ◽  
Author(s):  
Vincent M. Borderie ◽  
Najat Mourra ◽  
Laurent Laroche
Keyword(s):  
Growth Factors ◽  
Fetal Calf Serum ◽  
Calf Serum ◽  
Three Dimensional ◽  
Fibroblast Growth Factors ◽  
Collagen Gel ◽  
Fibroblast Growth ◽  
Hepatocyte Growth ◽  
Collagen Gel Matrix ◽  
Human Keratocytes

Three-dimensional structures of acidic and basic fibroblast growth factors

Science ◽  
1991 ◽  
Vol 251 (4989) ◽  
pp. 90-93 ◽  
Author(s):  
X Zhu ◽  
H Komiya ◽  
A Chirino ◽  
S Faham ◽  
G. Fox ◽  
...  
Keyword(s):  
Growth Factors ◽  
Three Dimensional ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth

Role of phytochemicals in the inhibition of epithelial–mesenchymal transition in cancer metastasis

2016 ◽  
Vol 7 (9) ◽  
pp. 3677-3685 ◽  
Author(s):  
Eun-Kyung Kim ◽  
Eun-Ju Choi ◽  
Trishna Debnath
Keyword(s):  
Growth Factors ◽  
Signaling Pathways ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
Scatter Factor ◽  
Mesenchymal Transition ◽  
Hepatocyte Growth

Epithelial–mesenchymal transition (EMT) development is controlled by several signaling pathways including Hedgehog, Wnt, fibroblast growth factors (FGF), hepatocyte growth factor/scatter factor (HGF),etc. Phytochemicals is very promising therapeutic candidate that inhibit the progression of EMT by inhibiting the signaling pathways.

Cytogenetics, Immunostaining for Fibroblast Growth Factors, p53 Sequencing, and Clinical Features of Two Cases of Cystosarcoma Phyllodes

2000 ◽  
Vol 5 (3) ◽  
pp. 179-190 ◽  
Author(s):  
PAUL V. WOOLLEY ◽  
SUSANNE M. GOLLIN ◽  
WAHEEB RISKALLA ◽  
SYDNEY FINKELSTEIN ◽  
DAVID F. STEFANIK ◽  
...  
Keyword(s):  
Growth Factors ◽  
Clinical Features ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
Cystosarcoma Phyllodes

Implications of Fibroblast Growth Factors (FGFs) in Cancer: From Prognostic to Therapeutic Applications

2019 ◽  
Vol 20 (8) ◽  
pp. 852-870
Author(s):  
Hassan Dianat-Moghadam ◽  
Ladan Teimoori-Toolabi
Keyword(s):  
Growth Factors ◽  
Wound Repair ◽  
Fibroblast Growth Factors ◽  
Predictive Biomarkers ◽  
Fibroblast Growth ◽  
Loss Of Function ◽  
Cellular Processes ◽  
Fgfr Signaling ◽  
Proliferation And Metastasis ◽  
Immense Potential

Fibroblast growth factors (FGFs) are pleiotropic molecules exerting autocrine, intracrine and paracrine functions via activating four tyrosine kinase FGF receptors (FGFR), which further trigger a variety of cellular processes including angiogenesis, evasion from apoptosis, bone formation, embryogenesis, wound repair and homeostasis. Four major mechanisms including angiogenesis, inflammation, cell proliferation, and metastasis are active in FGF/FGFR-driven tumors. Furthermore, gain-of-function or loss-of-function in FGFRs1-4 which is due to amplification, fusions, mutations, and changes in tumor–stromal cells interactions, is associated with the development and progression of cancer. Although, the developed small molecule or antibodies targeting FGFR signaling offer immense potential for cancer therapy, emergence of drug resistance, activation of compensatory pathways and systemic toxicity of modulators are bottlenecks in clinical application of anti-FGFRs. In this review, we present FGF/FGFR structure and the mechanisms of its function, as well as cross-talks with other nodes and/or signaling pathways. We describe deregulation of FGF/FGFR-related mechanisms in human disease and tumor progression leading to the presentation of emerging therapeutic approaches, resistance to FGFR targeting, and clinical potentials of individual FGF family in several human cancers. Additionally, the underlying biological mechanisms of FGF/FGFR signaling, besides several attempts to develop predictive biomarkers and combination therapies for different cancers have been explored.

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