Transforming growth factor β2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development

2001 ◽  
Vol 239 (3) ◽  
pp. 199-207 ◽  
Author(s):  
G. Picht ◽  
U. Welge-Luessen ◽  
F. Grehn ◽  
E. Lütjen-Drecoll
Keyword(s):  
Growth Factor ◽  
Aqueous Humor ◽  
Transforming Growth Factor ◽  
Filtering Bleb ◽  
Different Types ◽  
Transforming Growth Factor Β2

Transforming growth factor-β2 levels in aqueous humor of glaucomatous eyes

2001 ◽  
Vol 239 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Masaru Inatani ◽  
Hidenobu Tanihara ◽  
Hideto Katsuta ◽  
Megumi Honjo ◽  
Noriaki Kido ◽  
...  
Keyword(s):  
Growth Factor ◽  
Aqueous Humor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β2

scholarly journals Active transforming growth factor-β2 in the aqueous humor of posterior polymorphous corneal dystrophy patients

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175509 ◽  
Author(s):  
Andrea Stadnikova ◽  
Lubica Dudakova ◽  
Pavlina Skalicka ◽  
Zdenek Valenta ◽  
Martin Filipec ◽  
...  
Keyword(s):  
Growth Factor ◽  
Aqueous Humor ◽  
Transforming Growth Factor ◽  
Corneal Dystrophy ◽  
Posterior Polymorphous Corneal Dystrophy ◽  
Transforming Growth Factor Β2

The lens influences aqueous humor levels of transforming growth factor-β2

1998 ◽  
Vol 236 (4) ◽  
pp. 305-311 ◽  
Author(s):  
J. B. Allen ◽  
Michael G. Davidson ◽  
Mark P. Nasisse ◽  
Lloyd N. Fleisher ◽  
M. Christine McGahan
Keyword(s):  
Growth Factor ◽  
Aqueous Humor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β2

scholarly journals Elevated Transforming Growth Factor-β2 in the Aqueous Humor: A Possible Explanation for High Rate of Capsular Contraction Syndrome in High Myopia

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Keke Zhang ◽  
Xiangjia Zhu ◽  
Minjie Chen ◽  
Xinghuai Sun ◽  
Jin Yang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Western Blot ◽  
Aqueous Humor ◽  
Transforming Growth Factor Beta ◽  
High Myopia ◽  
Transforming Growth Factor ◽  
High Rate ◽  
Histopathological Analysis ◽  
Capsular Contraction ◽  
Transforming Growth Factor Β2

Purpose.The purpose of the study was to elucidate the role of transforming growth factor-beta 2 (TGF-β2) in the development of high myopic capsular contraction syndrome.Methods.Nineteen cases of capsular contraction syndrome, including 14 with high myopia, were collected, and their clinical data were reviewed. Aqueous humor and anterior capsular membranes were obtained during capsulotomy. Hematoxylin-eosin and immunohistochemical staining with anti-TGF-β2 antibody were performed on capsular membranes. TGF-β2 levels in aqueous humor were assayed using ELISA and western blot.Results.High myopia was significantly associated with the incidence of capsular contraction syndrome (odds ratio: 14.74,P<0.001, 95% CI: 5.29–41.05). Histopathological analysis revealed proliferation of fibroblast-like lens epithelial cells on the shrunken anterior capsule, labeled with TGF-β2 antibodies. ELISA and Western blot showed higher levels of TGF-β2 in aqueous humor of patients with capsular contraction syndrome and high myopia.Conclusions.High myopia is a risk factor for capsular contraction syndrome. Elevated TGF-β2 levels in high myopic cataract patients may play an important role in the pathogenesis of capsular contraction syndrome.

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