Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance

1999 ◽  
Vol 246 (7) ◽  
pp. 578-586 ◽  
Author(s):  
P. Flachenecker ◽  
Annalaska Wolf ◽  
Miriam Krauser ◽  
H.-P. Hartung ◽  
Karlheinz Reiners
Keyword(s):  
Multiple Sclerosis ◽  
Autonomic Dysfunction ◽  
Orthostatic Intolerance ◽  
Cardiovascular Autonomic Dysfunction

scholarly journals Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies

2020 ◽  
Vol 9 (2) ◽  
pp. 335 ◽  
Author(s):  
Oliver Findling ◽  
Larissa Hauer ◽  
Thomas Pezawas ◽  
Paulus S. Rommer ◽  
Walter Struhal ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Autonomic Dysfunction ◽  
Orthostatic Intolerance ◽  
Current Knowledge ◽  
Evidence Base ◽  
Cardiovascular Complications ◽  
Rate Variation ◽  
Cardiac Autonomic Dysfunction ◽  
Reduce Life Expectancy

Cardiac autonomic dysfunction (CAD) has been reported in patients with multiple sclerosis (MS). This systematic review summarizes the evidence for the types and prevalence of CAD in MS patients, as well as its association with MS type, disease characteristics, fatigue and immunotherapies used to treat MS. The analysis revealed that CAD is correlated with pathophysiological processes of MS, can trigger serious cardiovascular complications that may reduce life expectancy, and may have implications for treatment with immunotherapies, especially fingolimod. Numerous mainly small case–control or cohort studies have reported various measures of CAD (particularly heart rate variation) in MS patients, showing higher rates of abnormality versus controls. A smaller number of studies have reported on cardiac autonomic symptoms in MS, including orthostatic intolerance/dizziness in around 50% of patients. CAD also appears to be associated with disease duration and to be more common in progressive than relapsing–remitting MS. However, although a substantial evidence base suggests that assessing CAD in people with MS may be important, standardised methods to evaluate CAD in these patients have not yet been established. In addition, no studies have yet looked at whether treating CAD can reduce the burden of MS symptoms, disease activity or the rate of progression.

scholarly journals Corrigendum to “Cardiovascular autonomic dysfunction in multiple sclerosis: A meta-analysis” [Mult. Scler. Relat. Disord. 4 (2015) 104–111]

2015 ◽  
Vol 4 (4) ◽  
pp. 385 ◽  
Author(s):  
Juan Manuel Racosta ◽  
Luciano A. Sposato ◽  
Sarah A. Morrow ◽  
Lauren Cipriano ◽  
Kurt Kimpinski ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Autonomic Dysfunction ◽  
Meta Analysis ◽  
Cardiovascular Autonomic Dysfunction

Cardiovascular autonomic dysfunction in multiple sclerosis is likely related to brainstem lesions

1993 ◽  
Vol 120 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Giuseppe Vita ◽  
M. Carolina Fazio ◽  
Sonia Milone ◽  
Alfredo Blandino ◽  
Laura Salvi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Autonomic Dysfunction ◽  
Brainstem Lesions ◽  
Cardiovascular Autonomic Dysfunction

scholarly journals Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?

2021 ◽  
Vol 8 (11) ◽  
pp. 156
Author(s):  
Giandomenico Bisaccia ◽  
Fabrizio Ricci ◽  
Vittoria Recce ◽  
Antonio Serio ◽  
Giovanni Iannetti ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Autonomic Dysfunction ◽  
Orthostatic Intolerance ◽  
Current Evidence ◽  
Postural Orthostatic Tachycardia Syndrome ◽  
Inappropriate Sinus Tachycardia ◽  
Major Health ◽  
Autonomic Nervous ◽  
Cardiovascular Autonomic Dysfunction

Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and “brain fog”. Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.

scholarly journals Cardiovascular Autonomic Dysfunction and Falls in People With Multiple Sclerosis: Is There a Link? An Opinion Article

2020 ◽  
Vol 14 ◽  
Author(s):  
Tobia Zanotto ◽  
Manuel E. Hernandez ◽  
Cristina N. Medrano ◽  
Kenneth R. Wilund ◽  
Jacob J. Sosnoff
Keyword(s):  
Multiple Sclerosis ◽  
Autonomic Dysfunction ◽  
Cardiovascular Autonomic Dysfunction ◽  
Opinion Article

Cardiovascular autonomic dysfunction in multiple sclerosis: A meta-analysis

2015 ◽  
Vol 4 (2) ◽  
pp. 104-111 ◽  
Author(s):  
Juan Manuel Racosta ◽  
Luciano A. Sposato ◽  
Sarah A. Morrow ◽  
Lauren Cipriano ◽  
Kurt Kimpiski ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Autonomic Dysfunction ◽  
Meta Analysis ◽  
Cardiovascular Autonomic Dysfunction

scholarly journals Cardiac stunning as first manifestation of multiple sclerosis: A case report reminding us not to overlook cardiovascular autonomic dysfunction in multiple sclerosis

2016 ◽  
Vol 22 (6) ◽  
pp. 847-848 ◽  
Author(s):  
Max J Hilz
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Autonomic Dysfunction ◽  
Cardiovascular Autonomic Dysfunction ◽  
Life Threatening ◽  
Tako Tsubo Cardiomyopathy ◽  
Cardiac Stunning

Autonomic dysfunction is common but frequently overlooked in multiple sclerosis (MS) patients. The case of a Tako-Tsubo cardiomyopathy on which this commentary is based shows that centrally triggered autonomic dysfunction may be the first life-threatening manifestation of MS.

Characterization of Autonomic Dysfunction Among Migraineurs With and Without Complaints of Orthostatic Intolerance

2020 ◽  
Author(s):  
Mark Jay Stillman ◽  
Fetnat Fouad-Tarazi ◽  
Lan Zhou ◽  
Robert Shields ◽  
Fredrick Jaeger ◽  
...  
Keyword(s):  
Autonomic Dysfunction ◽  
Orthostatic Intolerance
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