scholarly journals Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment

1999 ◽  
Vol 246 (6) ◽  
pp. 477-485 ◽  
Author(s):  
Pieter Jelle Visser ◽  
P. Scheltens ◽  
Frans R. J. Verhey ◽  
Ben Schmand ◽  
Leonore J. Launer ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Dysfunction ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy

CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment

2007 ◽  
Vol 28 (7) ◽  
pp. 1070-1074 ◽  
Author(s):  
F.H. Bouwman ◽  
S.N.M. Schoonenboom ◽  
W.M. van der Flier ◽  
E.J. van Elk ◽  
A. Kok ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Csf Biomarkers ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy

scholarly journals Corneal Nerve and Brain Imaging in Mild Cognitive Impairment and Dementia

2020 ◽  
Vol 77 (4) ◽  
pp. 1533-1543
Author(s):  
Eiman Al-Janahi ◽  
Georgios Ponirakis ◽  
Hanadi Al Hamad ◽  
Surjith Vattoth ◽  
Ahmed Elsotouhy ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Medial Temporal Lobe Atrophy ◽  
Non Invasive ◽  
Corneal Confocal Microscopy ◽  
Corneal Nerve ◽  
Lobe Atrophy

Background: Visual rating of medial temporal lobe atrophy (MTA) is an accepted structural neuroimaging marker of Alzheimer’s disease. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic technique that detects neuronal loss in peripheral and central neurodegenerative disorders. Objective: To determine the diagnostic accuracy of CCM for mild cognitive impairment (MCI) and dementia compared to medial temporal lobe atrophy (MTA) rating on MRI. Methods: Subjects aged 60–85 with no cognitive impairment (NCI), MCI, and dementia based on the ICD-10 criteria were recruited. Subjects underwent cognitive screening, CCM, and MTA rating on MRI. Results: 182 subjects with NCI (n = 36), MCI (n = 80), and dementia (n = 66), including AD (n = 19, 28.8%), VaD (n = 13, 19.7%), and mixed AD (n = 34, 51.5%) were studied. CCM showed a progressive reduction in corneal nerve fiber density (CNFD, fibers/mm2) (32.0±7.5 versus 24.5±9.6 and 20.8±9.3, p < 0.0001), branch density (CNBD, branches/mm2) (90.9±46.5 versus 59.3±35.7 and 53.9±38.7, p < 0.0001), and fiber length (CNFL, mm/mm2) (22.9±6.1 versus 17.2±6.5 and 15.8±7.4, p < 0.0001) in subjects with MCI and dementia compared to NCI. The area under the ROC curve (95% CI) for the diagnostic accuracy of CNFD, CNBD, CNFL compared to MTA-right and MTA-left for MCI was 78% (67–90%), 82% (72–92%), 86% (77–95%) versus 53% (36–69%) and 40% (25–55%), respectively, and for dementia it was 85% (76–94%), 84% (75–93%), 85% (76–94%) versus 86% (76–96%) and 82% (72–92%), respectively. Conclusion: The diagnostic accuracy of CCM, a non-invasive ophthalmic biomarker of neurodegeneration, was high and comparable with MTA rating for dementia but was superior to MTA rating for MCI.

scholarly journals Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease

2017 ◽  
Vol 44 (1-2) ◽  
pp. 12-24 ◽  
Author(s):  
Karin Persson ◽  
Maria Lage Barca ◽  
Rannveig Sakshaug Eldholm ◽  
Lena Cavallin ◽  
Jūratė Šaltytė Benth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Delayed Recall ◽  
Medial Temporal Lobe Atrophy ◽  
Adjusted Model ◽  
Lobe Atrophy

Background/Aims: To evaluate whether visual assessment of medial temporal lobe atrophy (vaMTA) can predict 2-year conversion from mild cognitive impairment (MCI) to dementia and progression of MCI and Alzheimer's disease dementia as measured by the Clinical Dementia Rating Scale Sum of Boxes score (CDR-SB). Methods: vaMTA was performed in 94 patients with MCI according to the Winblad criteria and in 124 patients with AD according to ICD-10 and NINCDS-ADRDA criteria. Demographic data, the Consortium to Establish a Registry for Alzheimer's Disease 10-word delayed recall, APOE ɛ4 status, Cornell Scale for Depression in Dementia, and comorbid hypertension were used as covariates. Results: vaMTA was associated with MCI conversion in an unadjusted model but not in an adjusted model (p = 0.075), where delayed recall and APOE ɛ4 status were significant predictors. With CDR-SB change as the outcome, an interaction between vaMTA and diagnosis was found, but in the adjusted model only delayed recall and age were significant predictors. For vaMTA below 2, the association between vaMTA and CDR-SB change differed between diagnostic groups. Similar results were found based on a trajectory analysis. Conclusion: In adjusted models, memory function, APOE ɛ4 status and age were significant predictors of disease progression, not vaMTA. The association between vaMTA and CDR-SB change was different in patients with MCI and Alzheimer's disease dementia.

Correlation of medial temporal lobe atrophy with seizures in Alzheimer’s disease and mild cognitive impairment: A case control study

2017 ◽  
Vol 04 (02) ◽  
pp. 132-135
Author(s):  
Vikas Dhikav ◽  
Sharmila Duraisawmy ◽  
Kuljeet Anand
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Care Hospital ◽  
Medial Temporal Lobe Atrophy ◽  
Dementia Of Alzheimer’S Type ◽  
Lobe Atrophy

Abstract Background Seizures are common accompaniment of neurodegenerative disease. Though, Alzheimer’s disease (AD) is the most common cause, but seizures also occasionally occur in mild cognitive impairment (MCI). Material & methods We studied patients of Subjective Memory Complaints coming to the Department of Neurology of a Tertiary Care Hospital in Northern India from July 2012 to July 2015. A total of 171 patients were studied. Those with a diagnosis of AD/MCI with seizures were taken for the current study. A total of 30 controls with chronic diseases were taken for comparison. Medial Temporal Lobe Atrophy (MTA) Rating was done using Sheleten’s Visual Rating Scale. Results A total of 256 patients were screened and 171 had dementia of Alzheimer’s type (n = 75; M:F = 60:15) and 96 patients had MCI (M:F = 76:20). The mean MMSE of those with AD was 18.5 ± 3.3 was and that of the MCI was 26.6 ± 2.4. A total of 9 cases with AD had seizures and 6 had seizures in MCI group (total n = 15). Moderately strong correlation was obtained between MMSE of AD patients having seizures and MTA scoring. Conclusions Seizures are common in dementia of Alzheimer’s type and not uncommon in MCI. They have the potential to worsen the cognitive profile of the patient and need attention in these patients.

Sign in / Sign up

Export Citation Format

Share Document