Inhibitory Role of Eosinophils on Cell Surface Plasmin Generation by Bronchial Epithelial Cells: Inhibitory Effects of Transforming Growth Factor β

Lung ◽  
2001 ◽  
Vol 179 (1) ◽  
pp. 9-20 ◽  
Author(s):  
K. Hara ◽  
T. Hasegawa ◽  
H. Ooi ◽  
T. Koya ◽  
Y. Tanabe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Cell Surface ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Bronchial Epithelial Cells ◽  
Inhibitory Effects ◽  
Bronchial Epithelial ◽  
Inhibitory Role

Interleukin-10 Regulates Transforming Growth Factor-β Signaling in Cultured Human Bronchial Epithelial Cells

Respiration ◽  
2007 ◽  
Vol 74 (4) ◽  
pp. 454-459 ◽  
Author(s):  
Naoto Fueki ◽  
Hironori Sagara ◽  
Kazumi Akimoto ◽  
Mayumi Ota ◽  
Takenori Okada ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Interleukin 10 ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial

scholarly journals Transforming growth factor–β in tissue fibrosis

2020 ◽  
Vol 217 (3) ◽  
Author(s):  
Nikolaos G. Frangogiannis
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Cell Types ◽  
Cellular Targets ◽  
Extracellular Matrix Molecules ◽  
Interacting Networks

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β–driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.

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